MCQOPTIONS
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MCQOPTIONS
This section includes 925 Mcqs, each offering curated multiple-choice questions to sharpen your GPAT knowledge and support exam preparation. Choose a topic below to get started.
| 701. |
p-aminohippurate is used to measure |
| A. | effective hepatic blood flow |
| B. | effective renal blood flow |
| C. | CFR |
| D. | None of the above |
| Answer» C. CFR | |
| 702. |
Which option will be the best example of the physicochemical properties of drugs? |
| A. | Solubility, particle size, polymorphism, salt form, pseudo polymorphism, complexation, wettability, pH, Pressure of disintegration |
| B. | Pressure of disintegration, polymorphism, salt form, pseudo polymorphism, complexation, wettability, pH |
| C. | Solubility, particle size, polymorphism, salt form |
| D. | Solubility, particle size, polymorphism, salt form, pseudo polymorphism, complexation, wettability |
| Answer» E. | |
| 703. |
Hepatic excretion of drug with high extraction ratio is altered by |
| A. | Protein binding |
| B. | Blood flow |
| C. | both (a) & (b) |
| D. | None of the above |
| Answer» C. both (a) & (b) | |
| 704. |
The extent to which a drug is distributed is a tissue depends upon ___________ and _____________ |
| A. | The concentration of a drug, tissue/blood partition coefficient of drug |
| B. | Tissue volume, tissue/blood partition coefficient of drug |
| C. | Tissue surface area, tissue/blood partition coefficient of drug |
| D. | Blood density upon the tissue, tissue/blood partition coefficient of drug |
| Answer» C. Tissue surface area, tissue/blood partition coefficient of drug | |
| 705. |
How renal clearance ratio is expressed? |
| A. | Renal clearance of creatinine / renal clearance of the drug |
| B. | 1/renal clearance of the drug |
| C. | Renal clearance of drug/ renal clearance of creatinine |
| D. | 1/renal clearance of creatinine |
| Answer» D. 1/renal clearance of creatinine | |
| 706. |
Select the formula to calculate steady state concentration follows IV infusion |
| A. | Css= Infusion Rate/ Clearance |
| B. | Css= Clearance / Infusion Rate |
| C. | Css= Infusion Rate X Clearance |
| D. | Css = Infusion Rate - Clearance |
| Answer» B. Css= Clearance / Infusion Rate | |
| 707. |
Blood plasma belongs to |
| A. | Interstitial fluid |
| B. | Intracellular fluid |
| C. | Extracellular fluid |
| D. | All of the above |
| Answer» B. Intracellular fluid | |
| 708. |
The concentration of drug in blood or plasma will be comparatively in the GI tract. |
| A. | High |
| B. | Low |
| C. | Very High |
| D. | Very Low |
| Answer» B. Low | |
| 709. |
The area under serum concentration time curve of drug represents |
| A. | The biological half life of the drug |
| B. | Amount of drug biotransformed |
| C. | The amount of drug absorbed |
| D. | The amount of drug excreted in urine |
| Answer» E. | |
| 710. |
What is the function of the blood-testis barrier? |
| A. | Restricts the passage of drug to the testis |
| B. | Restricts the passage of drug to sperms |
| C. | Restricts the passage of drugs to spermatocytes |
| D. | Restricts the passage of drugs to spermatocytes and spermatids |
| Answer» E. | |
| 711. |
Which one of these options is not one of the limitations of pH-partition theory? |
| A. | Presence if virtual membrane pH |
| B. | Absorption of ionized drugs |
| C. | Influence of GI surface area |
| D. | Dissolution rate |
| Answer» E. | |
| 712. |
Which of the following equations correct for Henderson-Hasselbach equation for weak acids? |
| A. | PH = pKa – log (Unionized drug concentration /Ionized drug concentration) |
| B. | PH = pKa – log (Ionized drug concentration/ Unionized drug concentration) |
| C. | PH = pKa + log (Ionized drug concentration/ Unionized drug concentration) |
| D. | PH = pKa + log (Unionized drug concentration /Ionized drug concentration) |
| Answer» D. PH = pKa + log (Unionized drug concentration /Ionized drug concentration) | |
| 713. |
Renal clearance is expressed as |
| A. | Rate of urinary excretion / Plasma drug concentration |
| B. | Elimination Rate / Plasma drug concentration |
| C. | Rate of urinary excretion / Elimination Rate |
| D. | Elimination Rate |
| Answer» B. Elimination Rate / Plasma drug concentration | |
| 714. |
How the absolute surface area of hydrophobic drugs can be converted to their effective surface area? |
| A. | Use of surfactant |
| B. | Use of Hydrophobic diluents |
| C. | Use of surfactant and hydrophilic diluents |
| D. | No need of doing micronization |
| Answer» D. No need of doing micronization | |
| 715. |
A drug in the concentrated injection is absorbed faster. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 716. |
Stimulation of liver microsomal enzymes can: |
| A. | Require the dose increase of some drugs |
| B. | Require the dose decrease of some drugs |
| C. | Prolong the duration of the action of a drug |
| D. | Intensify the unwanted reaction of a drug |
| Answer» B. Require the dose decrease of some drugs | |
| 717. |
What is the mechanism of drug excretion for skin excretion? |
| A. | Active secretion |
| B. | Glomerular secretion |
| C. | Passive diffusion |
| D. | Passive reabsorption |
| Answer» D. Passive reabsorption | |
| 718. |
Displacement interactions are significant in the case of drugs which are more than 95% bound. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 719. |
Which of the following is alimentary route of administration when passage of drug through liver isminimized? |
| A. | Oral |
| B. | Transdermal |
| C. | Rectal |
| D. | Intraduodenal |
| Answer» D. Intraduodenal | |
| 720. |
Which of the following methods are used to determine Area Under curve? |
| A. | Cut and weigh method |
| B. | Trapezoidal method |
| C. | Integration method |
| D. | All of the above |
| Answer» E. | |
| 721. |
Distribution is…………….. |
| A. | irreversible process |
| B. | dynamic equilibrium process |
| C. | Both (a) & (b) |
| D. | none of the above |
| Answer» C. Both (a) & (b) | |
| 722. |
Which of the following is a not mechanism of drug absorption through GIT |
| A. | Pore transport |
| B. | Active transport |
| C. | Endocytosis |
| D. | Metastasis |
| Answer» E. | |
| 723. |
Which of the following drug selectively bound to extravascular tissues? |
| A. | Warfarin |
| B. | Diazepam |
| C. | Digitoxin |
| D. | Chloroquin |
| Answer» E. | |
| 724. |
In…………..Pharmacokinetic parameters for a drug can change with change in dose. |
| A. | Linear Pharmacokinetics |
| B. | Non-linear Pharmacokinetics |
| C. | Both of the above |
| D. | None of the above |
| Answer» C. Both of the above | |
| 725. |
Haemodialysis is also known as extracorporeal dialysis. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 726. |
Two or more drugs contain the same therapeutically active ingredient which elicits same pharmacological effects and can control the disease to the same extent are known to be pharmaceutic equivalent. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 727. |
In the case of hydrophobic drugs, micronization results in a decrease in effective surface area and thus fall is dissolution rate. Which of the below sentences cannot be a reason for the given statement? |
| A. | The hydrophobic surface of the drugs adsorbs onto their surface which inhibits their wettability |
| B. | The particles reaggregate to form larger particles due to their high surface free energy |
| C. | Extreme reduction in the particle size imparts surface charges that may prevent wetting |
| D. | Extreme reduction in the size brings the hydrophobic amino acids to the surface |
| Answer» E. | |
| 728. |
Which of the following is not measured in acute pharmacological response study? |
| A. | ECG |
| B. | EEG |
| C. | Pupil diameter |
| D. | Serum drug level |
| Answer» E. | |
| 729. |
A hydrophilic medicinal agent has |
| A. | Low ability to penetrate through the cell membrane lipids |
| B. | Easy permeation through the blood-brain barrier |
| C. | Penetrate through membranes by means of endocytosis |
| D. | High reabsorption in renal tubules |
| Answer» B. Easy permeation through the blood-brain barrier | |
| 730. |
For a certain drug, the bile flow rate is 0.7 ml/mm, the biliary drug concentration is 2g/ml and the plasma drug concentration is 0.8g/ml. What will be the bile clearance? |
| A. | 1.50 ml/mm |
| B. | 1.75 ml/mm |
| C. | 2.75 ml/mm |
| D. | 3 ml/mm |
| Answer» C. 2.75 ml/mm | |
| 731. |
Which of the following will be the slowest step in tablet drug absorption? |
| A. | Tablet disintegration to granules |
| B. | Granules disintegration to fine particles |
| C. | Fine particles dissolution |
| D. | Dissolution absorbed into the blood |
| Answer» B. Granules disintegration to fine particles | |
| 732. |
Which of the following drug bind to α1 globulin? |
| A. | Steroids |
| B. | Ferrous ion |
| C. | Carotenoid |
| D. | Vitamin D |
| Answer» B. Ferrous ion | |
| 733. |
Which of the following will be a disadvantage for the physiologic model? |
| A. | Prediction of drug concentration in various body regions |
| B. | Correlation of data in several animal species |
| C. | Obtaining experimental data for each of the organs |
| D. | The model gives an exact description of the drug concentration-time profile for any organ |
| Answer» D. The model gives an exact description of the drug concentration-time profile for any organ | |
| 734. |
Half life (t1/2) is the time required to: |
| A. | change the amount of a drug in plasma by half during elimination |
| B. | metabolize a half of an introduced drug into the active metabolite |
| C. | absorb a half of an introduced drug |
| D. | bind a half of an introduced drug to plasma proteins |
| Answer» B. metabolize a half of an introduced drug into the active metabolite | |
| 735. |
The process by which molecules diffuse from a region of higher concentration to a region of lowerconcentration and no external energy is expended is called |
| A. | Passive diffusion |
| B. | Active transport |
| C. | Pore transport |
| D. | Facilitation diffusion |
| Answer» B. Active transport | |
| 736. |
Transfer of drug from plasma to tissue depends on |
| A. | Weight of tissue |
| B. | Blood perfusion rate of tissue |
| C. | Size of tissue |
| D. | All of the above |
| Answer» C. Size of tissue | |
| 737. |
Maximum movement of drug across the membrane occurs by |
| A. | Completely ionised |
| B. | Unionised |
| C. | Partially ionised |
| D. | None of them |
| Answer» C. Partially ionised | |
| 738. |
What is the mechanism of drug excretion for biliary excretion? |
| A. | Active secretion |
| B. | Glomerular secretion |
| C. | Passive diffusion |
| D. | Passive reabsorption |
| Answer» B. Glomerular secretion | |
| 739. |
Which form of drug formulation has disintegration time? |
| A. | Injections |
| B. | Syrups |
| C. | Capsules and Tablets |
| D. | Only tablets |
| Answer» D. Only tablets | |
| 740. |
Bioavailability of drug from topical administration is affected by….. |
| A. | Skin condition |
| B. | Topical vehicle |
| C. | Application condition |
| D. | all of the above |
| Answer» E. | |
| 741. |
Which one of the following physicochemical property is more important for passive diffusion of drugs from the GIT? |
| A. | Partition coefficient |
| B. | Lipid solubility |
| C. | pH of GIT fluids |
| D. | dissolution constant |
| Answer» B. Lipid solubility | |
| 742. |
Which of the following drug can get distributed in the excess body space? |
| A. | Phenytoin |
| B. | Caffeine |
| C. | Digoxin |
| D. | Antibiotics |
| Answer» D. Antibiotics | |
| 743. |
Which creatinine clearance value shows severe renal failure? |
| A. | 120-130 ml/min |
| B. | 20-50 ml/min |
| C. | Below 10 ml/min |
| D. | 70-80 ml/min |
| Answer» D. 70-80 ml/min | |
| 744. |
Drug showing zero order kinetic of elimination |
| A. | Are more common than those showing first order kinetic |
| B. | Show plot of drug concentration vs time (linear Plot) |
| C. | Decrease in concentration exponentially with time |
| D. | Have half life independent of dose |
| Answer» C. Decrease in concentration exponentially with time | |
| 745. |
If a CNS drug is extensively ionized at pH of blood it will |
| A. | Penetrate the blood brain barrier slowly |
| B. | Penetrate the blood brain barrier rapidly |
| C. | Not penetrate blood brain barrier |
| D. | Be eliminated slowly |
| Answer» B. Penetrate the blood brain barrier rapidly | |
| 746. |
………………is the process of movement of unchanged drug from the site of administration to thesystemic circulation. |
| A. | Absorption |
| B. | Dissolution |
| C. | Distribution |
| D. | Elimination |
| Answer» B. Dissolution | |
| 747. |
In the equation X= Vd C, what does X stands for? |
| A. | Amount of drug in the blood |
| B. | Amount of drug in plasma |
| C. | Amount of drug in the tablet |
| D. | Amount of drug in the body |
| Answer» E. | |
| 748. |
The………………….. is common cause of both dose and time dependent kinetics |
| A. | Capacity limited Process |
| B. | Dose volume |
| C. | Enzyme induction |
| D. | None of the above |
| Answer» D. None of the above | |
| 749. |
Filtration fraction is |
| A. | Fraction of plasma passing through the kidney which is filtered at glomerulus |
| B. | Ratio of iulin clearance to PAH clearance |
| C. | Ration of CFR to RPF |
| D. | None of them |
| Answer» D. None of them | |
| 750. |
The term "biotransformation" includes the following. |
| A. | Accumulation of substances in a fat tissue |
| B. | Process of physicochemical and biochemical alteration of a drug in the body |
| C. | Binding of substances with plasma proteins |
| D. | Accumulation of substances in a tissue |
| Answer» C. Binding of substances with plasma proteins | |