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MCQOPTIONS
This section includes 925 Mcqs, each offering curated multiple-choice questions to sharpen your GPAT knowledge and support exam preparation. Choose a topic below to get started.
| 751. |
In the equation, Wo1/3-W1/3=Kt, K stands for ____________ |
| A. | The original mass of the drug |
| B. | Mass of the drug remaining after time t |
| C. | Dissolution constant |
| D. | Concentration of solute |
| Answer» D. Concentration of solute | |
| 752. |
Micronized form of drug absorbed fast because |
| A. | surface area increased |
| B. | viscosity increased |
| C. | angle of distribution increased |
| D. | none of the above |
| Answer» B. viscosity increased | |
| 753. |
Rate of absorption of drug by passive diffusion is maximum in |
| A. | Small intestine |
| B. | Large intestine |
| C. | Stomach |
| D. | Oesphagus |
| Answer» B. Large intestine | |
| 754. |
What is the function of a granulating agent in drug formulation? |
| A. | Promote cohesive compacts |
| B. | Added if the required dosage is inadequate so that necessary bulk can be produced |
| C. | Tablets can disintegrate easily |
| D. | Used as solubilizer |
| Answer» B. Added if the required dosage is inadequate so that necessary bulk can be produced | |
| 755. |
Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration. |
| A. | CuC |
| B. | C / Cu |
| C. | Cu/C |
| D. | 1/C Cu |
| Answer» D. 1/C Cu | |
| 756. |
Which drugs can easily pass the Placental barrier? |
| A. | Drugs having a molecular weight less than 1000 Dalton |
| B. | Moderate to high lipid solubility |
| C. | Drugs having a molecular weight less than 1000 Dalton and moderate to high lipid solubility, analgesics, and antibiotics |
| D. | Analgesics, antibiotics, etc |
| Answer» D. Analgesics, antibiotics, etc | |
| 757. |
The volume of distribution of drugs is: |
| A. | An expression of total body volume |
| B. | A measure of total fluid volume |
| C. | A relationship between the total amount of drug in the body and the concentration of the drug in the blood |
| D. | Proportional to bioavailability of the drug |
| Answer» D. Proportional to bioavailability of the drug | |
| 758. |
Which of the following is the pharmacodynamics method of studying bioavailability? |
| A. | Acute pharmacologic response |
| B. | Plasma-level time studies |
| C. | Urinary excretion studies |
| D. | Stool excretion studies |
| Answer» B. Plasma-level time studies | |
| 759. |
In the equation log C = log Co – KEt/2.303, what does Co stand for _______ |
| A. | Plasma drug concentration after 60 min of i.v. injection |
| B. | Plasma drug concentration after 15 min of i.v. injection |
| C. | Plasma drug concentration after 30 min of i.v. injection |
| D. | Plasma drug concentration immediately after i.v. injection. |
| Answer» E. | |
| 760. |
Disintegration time is directly proportional to the amount of binder present in the tablet. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 761. |
Which of the following drug diffuses readily into the brain? |
| A. | Penicillin |
| B. | Thiopental |
| C. | Dopamine |
| D. | all of the above |
| Answer» C. Dopamine | |
| 762. |
All are characteristics of passive diffusion except |
| A. | Drugs moves down the concentration gradient. |
| B. | It is an energy independent process |
| C. | Drugs moves up the concentration gradient. |
| D. | It is non saturable process |
| Answer» D. It is non saturable process | |
| 763. |
The extent of drug-protein binding can change with both changes in protein and drug concentration. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 764. |
Which one of these is not a mechanism of the working of surfactants? |
| A. | Promote wetting by increasing the effective surface area |
| B. | Helps in the dissolution of drug |
| C. | Better membrane contact of the drug |
| D. | Decrease membrane permeability |
| Answer» E. | |
| 765. |
Metabolic transformation (phase 1) is: |
| A. | Glucuronide formation |
| B. | Binding to plasma proteins |
| C. | Acetylation and methylation of substances |
| D. | Tr |
| Answer» B. Binding to plasma proteins | |
| 766. |
Hepatic extraction ratio of 0.60 indicates that |
| A. | 40% drug is left after extraction by the liver |
| B. | 60% drug is left after extraction by the liver |
| C. | Only 0.6% drug is removed by the liver |
| D. | None of the above |
| Answer» B. 60% drug is left after extraction by the liver | |
| 767. |
Which kind of absorption mechanism is showing in the picture? |
| A. | Endocytosis |
| B. | Passive transport |
| C. | Active transport |
| D. | Facilitated diffusion |
| Answer» C. Active transport | |
| 768. |
Which model is also known as membrane permeation rate limited? |
| A. | Physiologic model |
| B. | Compartment model |
| C. | Noncompartment model |
| D. | Mammillary model |
| Answer» B. Compartment model | |
| 769. |
Only unbound or free drug is capable of being eliminated. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 770. |
What is the name of the drug binding site I of HSA? |
| A. | Tamoxifen binding site |
| B. | Digitoxin binding site |
| C. | Diazepam binding site |
| D. | Warfarin and azapropazone binding site |
| Answer» E. | |
| 771. |
The unit of k for zero order reaction is |
| A. | moles/litre/second |
| B. | moles |
| C. | moles/second |
| D. | moles/litre |
| Answer» B. moles | |
| 772. |
Which organ comprises the peripheral compartment in a two compartment model? |
| A. | Liver |
| B. | Lungs |
| C. | Kidneys |
| D. | Muscles |
| Answer» E. | |
| 773. |
Parenteral administration: |
| A. | Cannot be used with unconsciousness patients |
| B. | Generally results in a less accurate dosage than oral administration |
| C. | Usually produces a more rapid response than oral administration |
| D. | Is too slow for emergency use |
| Answer» D. Is too slow for emergency use | |
| 774. |
A Normal sized adult having hepatic clearance of a drug whose metabolism is limited by the rate ofblood flow to the liver would be |
| A. | 60 milliliters/min |
| B. | 120 milliliters/min |
| C. | 650 milliliters/min |
| D. | 1500 milliliters/min |
| Answer» E. | |
| 775. |
During pregnancy, drug distribution is more. Which of the following sentences describe the given fact better? |
| A. | The baby needs more drug |
| B. | The mother needs more drug due to high metabolism |
| C. | The surface area increases in the mother’s body due to the presence of uterus, placenta, and foetus. Thus more area for distribution of drugs |
| D. | The growth of the uterus, placenta, and foetus increases the volume thus increasing distribution. And even the baby forms a separate compartment for a drug to get distributed |
| Answer» E. | |
| 776. |
What will be the renal clearance if the rate of urinary excretion is 625 ml/min and plasma drugconcentration is 4.2 ng/ml? |
| A. | 148.80ml2/ng min |
| B. | 150ml2/ng min |
| C. | 152ml2/ng min |
| D. | 140ml2/ng min |
| Answer» B. 150ml2/ng min | |
| 777. |
On which individuals study of newly invented medicines are not done? |
| A. | Pregnant and elderly |
| B. | Fasting person |
| C. | Healthy person |
| D. | Adult male |
| Answer» B. Fasting person | |
| 778. |
What does the interfacial barrier model states? |
| A. | An intermediate concentration exists at the interface |
| B. | Turbulence in the dissolution medium exists at the solid/liquid interface |
| C. | Formation a thin film or layer at the solid-liquid interface |
| D. | Solutes passes easily through the interfaces |
| Answer» B. Turbulence in the dissolution medium exists at the solid/liquid interface | |
| 779. |
What is total systemic clearance? |
| A. | Sum of clearance from kidney |
| B. | Sum of clearance from kidney and liver |
| C. | Sum of clearance form non-renal clearances |
| D. | Sum of renal and non-renal clearances |
| Answer» E. | |
| 780. |
Pharmacokinetics parameters change as per………… of dose administered? |
| A. | Size |
| B. | Route |
| C. | Both of free above |
| D. | None of the above |
| Answer» B. Route | |
| 781. |
If the steady-state plasma concentration is directly proportional to the dose, then ……….in thekinetics exists. |
| A. | Linearity |
| B. | Non-linearity |
| C. | Both of the above |
| D. | None of the above |
| Answer» B. Non-linearity | |
| 782. |
Which of the following decreasing order of blood flow rate through the muscular tissue is in theright order? |
| A. | Arm > thigh > buttocks |
| B. | Arm > buttocks > thigh |
| C. | Buttocks > thigh > arm |
| D. | Thigh > arm > buttocks |
| Answer» B. Arm > buttocks > thigh | |
| 783. |
Which are the two rate-determining step of drug absorption when given orally? |
| A. | Disintegration and deaggregation |
| B. | Disintegration and Dissolution |
| C. | Dissolution and permeation through the membrane |
| D. | Permeation through the membrane and Disintegration |
| Answer» D. Permeation through the membrane and Disintegration | |
| 784. |
……………… involves the engulfment of small molecules or fluid. |
| A. | Endocytosis |
| B. | Pinocytosis |
| C. | Phagocytosis |
| D. | None of the above |
| Answer» C. Phagocytosis | |
| 785. |
What is interaction of phenobarbitone and warfarin? |
| A. | Displacement of warfarin from binding site |
| B. | Decreased absorption of warfarin |
| C. | Increase metabolism of warfarin |
| D. | Decreased metabolism of warfarin |
| Answer» B. Decreased absorption of warfarin | |
| 786. |
Ibuprofen a weak acid, in the stomach will be present in which of the given form? |
| A. | Ionized form mostly |
| B. | Non-ionized form mostly |
| C. | Half ionized and half no ionized |
| D. | Will form aggregate |
| Answer» C. Half ionized and half no ionized | |
| 787. |
If the drug Y bind with plasma albumin with 10 times more affinity than drug X. Which the givenstatement is true? |
| A. | Apparent volume of distribution of drug X decrease |
| B. | Free concentration of drug X in blood will be increase |
| C. | Apparent volume of distribution of drug Y decrease |
| D. | Toxicity of drug Y increase |
| Answer» C. Apparent volume of distribution of drug Y decrease | |
| 788. |
Drug having a small partition coefficient can rapidly penetrate the lipid membrane but diffusionthrough the unstirred water layer is a rate-limiting step. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 789. |
What is the half life of a drug with a volume of distribution of 100U70kg and a clearance of 7t/hr/70kg |
| A. | 15 hours |
| B. | 10 hours |
| C. | 13.5 hours |
| D. | 5 hours |
| Answer» C. 13.5 hours | |
| 790. |
What is the major difference between Facilitated diffusion and Passive diffusion? |
| A. | Carrier-mediated transport |
| B. | Downhill transport |
| C. | Energy is used |
| D. | Inhibition by metabolic poisons |
| Answer» B. Downhill transport | |
| 791. |
Primary binding site for albumin is ………………binding site. |
| A. | Warfarin |
| B. | Diazepam |
| C. | Digitoxin |
| D. | Tamoxifen |
| Answer» B. Diazepam | |
| 792. |
Viscous fluids and oils are administered in hard gelatin capsules. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 793. |
What is the equation to find out hepatic clearance? |
| A. | Plasma drug concentration/rate of elimination by the kidney |
| B. | Rate of elimination by kidney/plasma drug concentration |
| C. | 1 / rate of elimination by the kidney |
| D. | 1 / plasma drug concentration |
| Answer» C. 1 / rate of elimination by the kidney | |
| 794. |
Which of the following drug is not intended for pulmonary administration? |
| A. | Bronchodilators |
| B. | Antiallergics |
| C. | NSAIDs |
| D. | Anti-inflammatory steroids |
| Answer» D. Anti-inflammatory steroids | |
| 795. |
The volume of distribution (Vd) relates: |
| A. | The amount of a drug in the body to the concentration of a drug in plasma |
| B. | An uncharged drug reaching the systemic circulation |
| C. | Single to a daily dose of an administrated drug |
| D. | An administrated dose to a body weight |
| Answer» B. An uncharged drug reaching the systemic circulation | |
| 796. |
An example of lubricants will be __________ |
| A. | PVP |
| B. | Carbowaxes |
| C. | CMC |
| D. | Tetracycline |
| Answer» C. CMC | |
| 797. |
According to the pH-partition theory which form of the drug gets absorbed mostly? |
| A. | Hydrated form |
| B. | Aggregated form |
| C. | Ionised |
| D. | Unionised |
| Answer» E. | |
| 798. |
Tick the drug type for which microsomal oxidation is the most prominent: |
| A. | Lipid soluble |
| B. | Water soluble |
| C. | Low molecular weight |
| D. | High molecular weight |
| Answer» B. Water soluble | |
| 799. |
Which of the following is not a factor influencing pulmonary excretion? |
| A. | Pulmonary blood flow |
| B. | The solubility of volatile substance |
| C. | Rate of respiration |
| D. | Heart rate |
| Answer» E. | |
| 800. |
Drug distribution in an organ depends on………… |
| A. | Organ size |
| B. | Perfusion rate |
| C. | Partition Coefficient |
| D. | all of the above |
| Answer» E. | |