MCQOPTIONS
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MCQOPTIONS
This section includes 925 Mcqs, each offering curated multiple-choice questions to sharpen your GPAT knowledge and support exam preparation. Choose a topic below to get started.
| 801. |
T % (Half life time) of a drug can determine all of the following except |
| A. | Closing interval |
| B. | Therapeutic dose |
| C. | Elimination time |
| D. | Steady plasma concentration |
| Answer» C. Elimination time | |
| 802. |
IV infusion model follows |
| A. | Zero order absorption and first order elimination kinetic |
| B. | No absorption and first order elimination kinetic |
| C. | No absorption and Zero order elimination kinetic |
| D. | First order absorption and first order elimination kinetic |
| Answer» B. No absorption and first order elimination kinetic | |
| 803. |
What reasons make tissue-drug binding important for drug distribution? |
| A. | Increases the volume of distribution of drugs and results in localization of drug at a specific site |
| B. | Increases the volume of distribution of drugs |
| C. | Results in localization of drugs at a tissue specific site |
| D. | Increases in absorption from the tissue due to concentration increasing |
| Answer» B. Increases the volume of distribution of drugs | |
| 804. |
An adult male with age 22 has height 240cm, weight 85kg, serum creatinine of 0.8mg will have ______________ creatinine clearance. |
| A. | 150 ml/min |
| B. | 160 ml/min |
| C. | 170.13 ml/min |
| D. | 174.131 ml/min |
| Answer» E. | |
| 805. |
Acids in the pKa range 2.5-7.5 are greatly affected by changes in pH making their absorption pHdependent. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 806. |
Fat is act as reservoir for……………………… Drugs |
| A. | Highly water soluble |
| B. | Lower lipid soluble |
| C. | Highly lipid soluble |
| D. | Lower lipid soluble |
| Answer» D. Lower lipid soluble | |
| 807. |
What is optimal multiple dosage regimen? |
| A. | The concentration of active agent in the drug formulation |
| B. | Dosage which maintains the plasma concentration within the therapeutic window. |
| C. | The manner in which a drug is taken |
| D. | The manner in which drug given to child |
| Answer» C. The manner in which a drug is taken | |
| 808. |
Which drugs bind to HSA easily? |
| A. | Cationic drug |
| B. | Anionic drug |
| C. | Lipophilic drug |
| D. | Neutral drug |
| Answer» C. Lipophilic drug | |
| 809. |
Ka is estimated by |
| A. | Method of Residuals |
| B. | Loo Riegelman method |
| C. | Both a and b |
| D. | None of the above |
| Answer» D. None of the above | |
| 810. |
The loading dose of a drug is based upon the |
| A. | time taken for complete elimination |
| B. | percentage of drug excreted unchanged in urine |
| C. | percentage of drug bound to plasma protein |
| D. | apparent volume of distribution and the desired drug concentration in plasma |
| Answer» E. | |
| 811. |
A drug with poor stability means higher bioavailability. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 812. |
Amorphous forms of drugs are |
| A. | less soluble than crystal forms |
| B. | more soluble than crystal forms |
| C. | also called solvates |
| D. | practically insoluble |
| Answer» C. also called solvates | |
| 813. |
In the equation G=Ki (Cs-Cb), what does G stands for______________ |
| A. | Dissolution rate per unit area |
| B. | Effective interfacial transport constant |
| C. | Concentration of the solute |
| D. | Concentration of the impurity |
| Answer» B. Effective interfacial transport constant | |
| 814. |
Lipid soluble drugs have |
| A. | Low Vd |
| B. | high Vd |
| C. | No Vd |
| D. | none of the above |
| Answer» C. No Vd | |
| 815. |
Which kind of membrane is used in haemodialysis? |
| A. | Artificial Semipermeable membrane |
| B. | Permeable membrane |
| C. | Natural semipermeable membrane of the peritoneal cavity |
| D. | Artificial permeable membrane |
| Answer» B. Permeable membrane | |
| 816. |
Which organs will make up the peripheral compartment? |
| A. | Lungs |
| B. | Liver |
| C. | Kidneys |
| D. | Pancreas |
| Answer» E. | |
| 817. |
Name the different methods used to estimate Km and Vmax graphically. |
| A. | Direct Linear plot |
| B. | Lineweaver —Burke plot or Klotz Plot |
| C. | Graphical Method |
| D. | All of the above |
| Answer» E. | |
| 818. |
Which of the following is correct statement about Nonlinear pharmacokinetics? |
| A. | The pharmacokinetic parameters of a drug will not change when multiple doses of drug are administered |
| B. | The graph of the relationship between the different factors involved (dose, blood plasma concentrations, elimination, etc.) gives a straight line. |
| C. | the plasma drug concentration changes either more or less than would be expected from a change in dose rate. |
| D. | None of the above |
| Answer» D. None of the above | |
| 819. |
Which of the given drugs bind to Β2 globulin? |
| A. | Steroidal drugs |
| B. | Vitamins A, D, E, K |
| C. | Ferrous ions |
| D. | Carotenoids |
| Answer» E. | |
| 820. |
Apparatus 5 of dissolution apparatus is known as |
| A. | Paddle over disk |
| B. | Flow-through- cell |
| C. | Reciprocating disk |
| D. | Basket |
| Answer» B. Flow-through- cell | |
| 821. |
Which one of these does not come under a physicochemical property of drugs? |
| A. | Drug solubility |
| B. | Disintegration time |
| C. | Dissolution rate |
| D. | Drug stability |
| Answer» C. Dissolution rate | |
| 822. |
Elimination rate constant (Kelim) is defined by the following parameter: |
| A. | rate of absorption |
| B. | maximal concentration of a substance in plasma |
| C. | highest single dose |
| D. | half life (t1/2) |
| Answer» E. | |
| 823. |
Which one of the following is not a characteristic for the small intestine? |
| A. | Peristaltic movement |
| B. | Long transit time |
| C. | High permeability |
| D. | PH 4-9 |
| Answer» E. | |
| 824. |
What is the chemical equivalence? |
| A. | Two or more drug products contain the same labeled chemical substance in the same amount |
| B. | Two or more drug products contain the same labeled chemical substance in different quantity |
| C. | Two or more drug products contain different labeled chemical substance giving the same therapeutic effect |
| D. | Two or more drug products contain the same labeled chemical substance giving a different therapeutic effect |
| Answer» B. Two or more drug products contain the same labeled chemical substance in different quantity | |
| 825. |
Ex-vivo models refer to……. |
| A. | in the body |
| B. | in the computer |
| C. | outside the body |
| D. | none of the above |
| Answer» D. none of the above | |
| 826. |
Which form of the drug has the highest bioavailability? |
| A. | Coated tablets |
| B. | Solutions |
| C. | Tablets |
| D. | Emulsions |
| Answer» C. Tablets | |
| 827. |
Which one is irrational statement for first order kinetics? |
| A. | Half life is a function of concentration of reactants |
| B. | Reaction rate is not a function of concentration of reactants |
| C. | Both a & b |
| D. | All of these |
| Answer» E. | |
| 828. |
What Will be the approximate Tmax of a drug exhibiting Ka of 2 hr-1 and K of 0.2 hr-1 ? |
| A. | 1.2 hr |
| B. | 2.4 hr |
| C. | 4.8 hr |
| D. | 2.0 hr |
| Answer» B. 2.4 hr | |
| 829. |
How do you calculate the ideal body weight for men? |
| A. | 50 kg +- 1kg/2.5cm above or below 150 cm in height |
| B. | 45 kg +- 1kg/2.5cm above or below 150 cm in height |
| C. | 40 kg +- 1kg/2.5cm above or below 150 cm in height |
| D. | 35 kg +- 1kg/2.5cm above or below 150 cm in height |
| Answer» B. 45 kg +- 1kg/2.5cm above or below 150 cm in height | |
| 830. |
Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particulardrug. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 831. |
Non-linear pharmacokinetics is also known as……… |
| A. | dose dependent |
| B. | enzyme capacity limited |
| C. | saturation pharmacokinetics |
| D. | All of the above |
| Answer» E. | |
| 832. |
Which drugs easily bind to adipose tissue? |
| A. | Cationic drug |
| B. | Anionic drug |
| C. | Lipophilic drug |
| D. | Neutral drug |
| Answer» D. Neutral drug | |
| 833. |
What is implied by active transport? |
| A. | Transport of drugs through a membrane by means of diffusion |
| B. | Transport without energy consumption |
| C. | Engulf of drug by a cell membrane with a new vesicle formation |
| D. | Tr |
| Answer» B. Transport without energy consumption | |
| 834. |
Aging of dosage form affects drug release. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 835. |
Which of the following drugs get distributed to the same extent in both lean and adipose tissue? |
| A. | Phenytoin |
| B. | Caffeine |
| C. | Digoxin |
| D. | Antibiotics |
| Answer» C. Digoxin | |
| 836. |
The rate at which drug reaches the systemic circulation is determined by the slowest of the various steps involved in the sequence. This is known as ____________ |
| A. | Disintegration time |
| B. | Dissolution time |
| C. | Rate limiting step |
| D. | Gastric Emptying time |
| Answer» D. Gastric Emptying time | |
| 837. |
Which organs comprise the central compartment in a two compartment model? |
| A. | Muscles |
| B. | Skin |
| C. | Adipose |
| D. | Liver |
| Answer» E. | |
| 838. |
Water soluble drugs have |
| A. | Low Vd |
| B. | high Vd |
| C. | No Vd |
| D. | none of the above |
| Answer» B. high Vd | |
| 839. |
Which vitamin molecules will bind to alpha 2 globulin? |
| A. | Vitamin b complexes |
| B. | Vitamin a and vitamin b |
| C. | Vitamin A, D, E, K |
| D. | Steroids bind to alpha 2 globulin, not vitamin |
| Answer» D. Steroids bind to alpha 2 globulin, not vitamin | |
| 840. |
What should be the disadvantage of cross over study on volunteers? |
| A. | Minimize the intersubject variability in plasma drug levels |
| B. | Minimize the carry-over effect |
| C. | Minimizes variations due to time effect |
| D. | Takes a lot of time to get the result of the study |
| Answer» E. | |
| 841. |
Area in which the carrier system is most dense is called as………….. |
| A. | Therapeutic window |
| B. | Absorption index |
| C. | Therapeutic index |
| D. | Absorption window |
| Answer» E. | |
| 842. |
Which of the following is not a step of renal excretion? |
| A. | Glomerular filtration |
| B. | Tubular filtration |
| C. | Tubular reabsorption |
| D. | Secretion |
| Answer» C. Tubular reabsorption | |
| 843. |
Active tubular reabsorption of drug depends on……………… |
| A. | pH of urine |
| B. | urine flow rate |
| C. | pKa of drug |
| D. | all of the above |
| Answer» E. | |
| 844. |
Bioequivalence is a relative term which denotes that the drug substance reaches the systemic circulation at the same relative rate or time. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 845. |
Which process involves alteration of drug distribution? |
| A. | Competitive binding |
| B. | Reduced plasma protein level |
| C. | Both |
| D. | None |
| Answer» D. None | |
| 846. |
The compartment models provide visual representation of various rate processes involved indrug disposition. Given statement is: |
| A. | False |
| B. | True |
| C. | Cannot say |
| D. | None of the above |
| Answer» C. Cannot say | |
| 847. |
How can you determine the extracellular fluid volume? |
| A. | Evans blue |
| B. | Na+ |
| C. | D20 |
| D. | Tritiated water |
| Answer» C. D20 | |
| 848. |
Biotransformation of a medicinal substance results in: |
| A. | Slower urinary excretion |
| B. | Faster urinary excretion |
| C. | Higher binding to membranes |
| D. | Easier distribution in organism |
| Answer» C. Higher binding to membranes | |
| 849. |
In one compartment open model, the term open indicates input and output is: |
| A. | unidirectional |
| B. | bidirectional |
| C. | non-directional |
| D. | none of the above |
| Answer» B. bidirectional | |
| 850. |
If drug has pKa value of 3 then at pH value of 7 what would be the degree of ionisation of the drug? |
| A. | Majority portion would be ionised |
| B. | Majority portion would be unionised |
| C. | Approximately 50% would be ionised and 50% unionised |
| D. | None of the above |
| Answer» B. Majority portion would be unionised | |