MCQOPTIONS
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MCQOPTIONS
This section includes 925 Mcqs, each offering curated multiple-choice questions to sharpen your GPAT knowledge and support exam preparation. Choose a topic below to get started.
| 651. |
Under the concept biopharmaceutics, hydrophobic drugs are |
| A. | Permeation rate limited |
| B. | Dissolution rate limited |
| C. | Both |
| D. | Initially permeation then dissolution rate limited |
| Answer» C. Both | |
| 652. |
The volume of plasma needed each minute to supply a substance at the rate at which it is excreted inthe urine is known as the |
| A. | diffusion constant of the substance |
| B. | clearance of the substance |
| C. | extraction ratio of the substance |
| D. | filtration rate of the substance |
| Answer» C. extraction ratio of the substance | |
| 653. |
The delivery of a drug through the skin is known as |
| A. | Sublingual |
| B. | Transdermal |
| C. | Inhalation |
| D. | Buccal |
| Answer» C. Inhalation | |
| 654. |
The cell membrane is ___________ |
| A. | Impermeable |
| B. | Semipermeable |
| C. | Permeable |
| D. | Permeable to only gases |
| Answer» D. Permeable to only gases | |
| 655. |
Concentration of drug at peak is known as …………drug concentration. |
| A. | maximum |
| B. | minimum |
| C. | lower |
| D. | none of the above |
| Answer» B. minimum | |
| 656. |
Energy is utilized in ………………… diffusion mechanism. |
| A. | Passive |
| B. | Active |
| C. | Pore |
| D. | Cellular |
| Answer» C. Pore | |
| 657. |
The rate of diffusion of drug across biological membrane is |
| A. | Directly proportional to the concentration gradients |
| B. | Dependant on route of administration |
| C. | Indirectly proportional to membrane thickness |
| D. | None of the above |
| Answer» B. Dependant on route of administration | |
| 658. |
The biological half-life of drug: |
| A. | is a constant physical property of the drug |
| B. | is a constant chemical property of the drug |
| C. | may be increased in patients with impaired renal failure |
| D. | may be decreased in patients by giving the drug by rapid I.V. injection |
| Answer» D. may be decreased in patients by giving the drug by rapid I.V. injection | |
| 659. |
Which kind of molecules cannot pass through a pore transport? |
| A. | Low Molecular weight molecules |
| B. | Water-soluble drugs |
| C. | Molecules up to 400 Dalton |
| D. | Molecules greater than 400 Dalton |
| Answer» E. | |
| 660. |
Which of the following is characteristic of the oral route? |
| A. | Absorption depends on GI tract secretion and motor function |
| B. | Fast onset of effect |
| C. | A drug reaches the blood passing the liver |
| D. | The sterilization of medicinal forms is obligatory |
| Answer» B. Fast onset of effect | |
| 661. |
The relative amount of an administered dose that reaches the general circulation and the rate at which this occurs. |
| A. | Biological |
| B. | Bioavailability |
| C. | Biopharmaceutics |
| D. | Bioequivalency |
| Answer» C. Biopharmaceutics | |
| 662. |
Intramuscular drug absorption is faster than intravascular. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 663. |
Which one of the following is the principal organ for drug excretion? |
| A. | Lungs |
| B. | Liver |
| C. | Kidneys |
| D. | Sweat glands |
| Answer» D. Sweat glands | |
| 664. |
What are the major stability problems which result in poor bioavailability of any orally administereddrugs? |
| A. | Acidic degradation |
| B. | Degradation by salivary amylase |
| C. | Degradation of the drug in inactive form |
| D. | Interaction with the excipients and degradation in an inactive form |
| Answer» E. | |
| 665. |
What is characteristic of the oral route? |
| A. | Fast onset of effect |
| B. | Absorption depends on GI tract secretion and motor function |
| C. | A drug reaches the blood passing the liver |
| D. | The sterilization of medicinal forms is obligatory |
| Answer» C. A drug reaches the blood passing the liver | |
| 666. |
Greater the surface area lesser is the dissolution. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 667. |
Which one of the following will be an example of organic diluents? |
| A. | Starch |
| B. | Dicalcium phosphate |
| C. | Tetracycline |
| D. | Tween 80 |
| Answer» B. Dicalcium phosphate | |
| 668. |
Which drugs are absorbed through pore transport? |
| A. | High lipophilicity |
| B. | Water-soluble drugs of molecular weight less than 100 Dalton |
| C. | Oily droplets |
| D. | Affinity for carriers |
| Answer» C. Oily droplets | |
| 669. |
The urinary excretion of the unchanged drug is directly proportional to the plasma concentration of adrug. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 670. |
Drug permeation through BBB can be improved by……….. |
| A. | Glycosylation |
| B. | Mannitol |
| C. | Dihydropyridine redox system |
| D. | all of the above |
| Answer» E. | |
| 671. |
The absorption of drugs like (quaternary ammonium compounds, sulphonic acid) are explained by |
| A. | Ion pair transport |
| B. | convective transport |
| C. | active transport |
| D. | Facilitated diffusion |
| Answer» B. convective transport | |
| 672. |
Bioavailability is defined as….. |
| A. | Rate of drug absorption |
| B. | Rate of drug distribution |
| C. | Rate of drug elimination |
| D. | Rate and extent of absorption |
| Answer» E. | |
| 673. |
Which is the largest organ of the human body? |
| A. | Liver |
| B. | Stomach |
| C. | Skin |
| D. | Lungs |
| Answer» D. Lungs | |
| 674. |
The comparison of bioavailability between two dosage forms. |
| A. | Bioequivalence |
| B. | Bioavailability |
| C. | Biopharmaceutics |
| D. | Biological |
| Answer» B. Bioavailability | |
| 675. |
The steady-state concentration of a drug can be double by: |
| A. | Doubling the both rate of infusion and concentration of drug. |
| B. | Doubling the rate of infusion only. |
| C. | Doubling the loading dose but maintaining the infusion rate. |
| D. | Tripling the rate of infusion. |
| Answer» C. Doubling the loading dose but maintaining the infusion rate. | |
| 676. |
Drugs undergoing first pass metabolism are advised not to be administered through |
| A. | Rectal |
| B. | Oral |
| C. | Transdermal |
| D. | Parenteral |
| Answer» C. Transdermal | |
| 677. |
Drug elimination involves....... (ADME are steps of pharmacokinetics) |
| A. | ADME |
| B. | DME |
| C. | ME |
| D. | E only |
| Answer» D. E only | |
| 678. |
What is the equation to find out the apparent volume of distribution? |
| A. | Amount of drug in the body/plasma drug concentration |
| B. | Plasma drug concentration/amount of drug in the body |
| C. | 1 / plasma drug concentration |
| D. | 1 / Amount of drug in the body |
| Answer» B. Plasma drug concentration/amount of drug in the body | |
| 679. |
Several factors such as the thickness of stratum corneum, presence of hair follicles, trauma, hydration of the skin, Grooming, exposure to chemicals determine the passive absorption of drugs from the surface of the skin to below. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 680. |
Dissolution test apparatus I as per IP is….. |
| A. | Paddle |
| B. | Basket |
| C. | Rotating basket |
| D. | Rotating paddle |
| Answer» B. Basket | |
| 681. |
The renal clearance of inulin is used as a measurement of |
| A. | effective renal blood flow |
| B. | rate of renal drug excretion |
| C. | active renal secretion |
| D. | glomerular filtration rate |
| Answer» E. | |
| 682. |
The central compartment consist of |
| A. | Highly perfused tissues |
| B. | Slowly equilibrate tissues |
| C. | Both a and b |
| D. | Reproductive org |
| Answer» B. Slowly equilibrate tissues | |
| 683. |
In vitro determination of bioavailability by dissolution rate is not the best way to determinetherapeutic efficacy. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 684. |
What will be the best definition for “carrier”? |
| A. | Nonpolar drugs can be transported through carrier-mediated transport |
| B. | Carrier binds reversibly and no covalently with the molecules |
| C. | It discharges the molecules and gets destroyed itself |
| D. | The carrier is a protein |
| Answer» C. It discharges the molecules and gets destroyed itself | |
| 685. |
HSA comes under which protein family? |
| A. | Globulin |
| B. | Receptor |
| C. | Enzymes |
| D. | Catalyst |
| Answer» C. Enzymes | |
| 686. |
The phenomenon of decreased drug metabolizing ability of the enzymes by drugs is known as…………… |
| A. | enzyme induction |
| B. | enzyme inhibition |
| C. | both (a) & (b) |
| D. | None of the above |
| Answer» C. both (a) & (b) | |
| 687. |
What is fluctuation? |
| A. | Cmax/Cmin |
| B. | Cmin / Cmax |
| C. | 1/Cmin |
| D. | 1/Cmax |
| Answer» B. Cmin / Cmax | |
| 688. |
…………form of weakly acidic drug absorbed well in stomach |
| A. | ionized |
| B. | unionised |
| C. | both |
| D. | none of the above |
| Answer» C. both | |
| 689. |
Drug having ……..half-lives take a very short time to achieve plateau concentration. |
| A. | shorter |
| B. | longer |
| C. | intermediate |
| D. | none of the above |
| Answer» B. longer | |
| 690. |
Which pharmacokinetic model is drawn on the basis of anatomic and physiologic data? |
| A. | Compartment model |
| B. | Caternary model |
| C. | Physiologic model |
| D. | Mammillary model |
| Answer» D. Mammillary model | |
| 691. |
In which model compartments are joined in series? |
| A. | Compartment model |
| B. | Caternary model |
| C. | Physiologic model |
| D. | Mammillary model |
| Answer» C. Physiologic model | |
| 692. |
What is dosage regimen? |
| A. | The concentration of active agent in the drug formulation |
| B. | The manner in which the drug is given to old people |
| C. | The manner in which a drug is taken |
| D. | The manner in which drug given to child |
| Answer» D. The manner in which drug given to child | |
| 693. |
The drug concentration between Minimum Effective Concentration and Maximum Safe Concentrationis called |
| A. | Therapeutic range |
| B. | Area under curve |
| C. | Peak response |
| D. | Pharmacological response |
| Answer» B. Area under curve | |
| 694. |
Most of drugs will bind with which of plasma protein |
| A. | Albumin |
| B. | Globulin |
| C. | Histone |
| D. | Glycoprotein |
| Answer» B. Globulin | |
| 695. |
Which drugs bind to RBC membrane? |
| A. | Pentobarbital |
| B. | Acetazolamide |
| C. | Imipramine |
| D. | Phenytoin |
| Answer» D. Phenytoin | |
| 696. |
Which tablets have longer Disintegration time? |
| A. | Single coated tablets |
| B. | Uncoated tablets |
| C. | Sugar-coated tablets |
| D. | Capsules |
| Answer» D. Capsules | |
| 697. |
A large amount of binders tends to increase the hardness of tablets. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 698. |
Hydrophobic drug with fine particle size in capsule results in a decreasing porosity of powder bed. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 699. |
Very weak bases having pKa < 5 |
| A. | Are ionized in the entire pH range of GIT |
| B. | Show absorption, which is pH dependent |
| C. | Are unionized at all pH values |
| D. | None of the above |
| Answer» D. None of the above | |
| 700. |
Which of the following process is also called "cell drinking"? |
| A. | Pinocytosis |
| B. | Phagocytosis |
| C. | Convective transport |
| D. | Active tr |
| Answer» B. Phagocytosis | |