In the case of hydrophobic drugs, micronization results in a decrease in effective surface area and thus fall is dissolution rate. Which of the below sentences cannot be a reason for the given statement?

• A. The hydrophobic surface of the drugs adsorbs onto their surface which inhibits their wettability
• B. The particles reaggregate to form larger particles due to their high surface free energy
• C. Extreme reduction in the particle size imparts surface charges that may prevent wetting
• D. Extreme reduction in the size brings the hydrophobic amino acids to the surface