MCQOPTIONS
Saved Bookmarks
MCQOPTIONS
This section includes 925 Mcqs, each offering curated multiple-choice questions to sharpen your GPAT knowledge and support exam preparation. Choose a topic below to get started.
| 601. |
Which of the following is the half life of zero order reaction? |
| A. | t1/2 = A0 /2k |
| B. | t1/2 = 0.693/2k |
| C. | t1/2 = A0 /2 |
| D. | t1/2 = 2k/ A0 |
| Answer» B. t1/2 = 0.693/2k | |
| 602. |
First pas metabolism occurs in: |
| A. | Liver |
| B. | In lungs |
| C. | In kidneys |
| D. | In pancreas |
| Answer» B. In lungs | |
| 603. |
Which of the following drugs accumulate in skin? |
| A. | Acidic drugs like imipramine |
| B. | Basic drugs like imipramine |
| C. | Halogenated hydrocarbons |
| D. | Chloroquine |
| Answer» E. | |
| 604. |
Which of the following is not a factor of renal excretion? |
| A. | Blood flow to the kidneys |
| B. | Urine pH |
| C. | Blood pH |
| D. | Disease state |
| Answer» D. Disease state | |
| 605. |
What is characteristic of the intramuscular route of drug administration? |
| A. | Only water solutions can be injected |
| B. | Oily solutions can be injected |
| C. | Opportunity of hypertonic solution injections |
| D. | The action develops slower, than at oral administration |
| Answer» C. Opportunity of hypertonic solution injections | |
| 606. |
………………… is an initial higher dose of a drug that may be given at the beginning of a course oftreatment before dropping down to a lower maintenance dose. |
| A. | Primary Dose |
| B. | Initial Dose |
| C. | Loading dose |
| D. | None of the above |
| Answer» D. None of the above | |
| 607. |
Compounds excreted in bile is classified into 3 categories. Which one of the following does not comeunder the categories? |
| A. | Drugs with bile/plasma concentration ratio approximately 1 |
| B. | Drugs with bile/plasma concentration ratio between 10-1000 |
| C. | Drugs with bile/plasma concentration ratio of less than 1 |
| D. | Drugs with bile/plasma concentration ratio above 1000 |
| Answer» E. | |
| 608. |
Which drugs deposit in hair shafts? |
| A. | Arsenicals |
| B. | Tetracycline |
| C. | Halogenated hydrocarbons |
| D. | Lipophilic drug |
| Answer» B. Tetracycline | |
| 609. |
The solvate can exist in different crystalline forms called as _________ |
| A. | Solvates |
| B. | Pseudopolymorphs |
| C. | Pseudopolymorphism |
| D. | Hydrate |
| Answer» C. Pseudopolymorphism | |
| 610. |
The multicompartment models are intended to provide……………. |
| A. | Therapeutic activity of the drug |
| B. | Achieve maximum efficacy |
| C. | Both of the above |
| D. | None of the above |
| Answer» D. None of the above | |
| 611. |
Heroin with pKa 7.8 will be in which form in intestinal pH? |
| A. | Ionized form mostly |
| B. | Unionized form mostly |
| C. | Half ionized and half no ionized |
| D. | Will form aggregate |
| Answer» C. Half ionized and half no ionized | |
| 612. |
Example of a drug which has PKa > 11 is ________ |
| A. | Cromolyn |
| B. | Imipramine |
| C. | Amitriptyline |
| D. | Mecamylamine |
| Answer» E. | |
| 613. |
The maximum amount of solute dissolved in a given solvent under standard conditions of temperature, pressure, and pH is known as __________ |
| A. | Dissolution rate |
| B. | Intrinsic dissolution |
| C. | Rate limiting step |
| D. | Absolute or intrinsic solubility |
| Answer» E. | |
| 614. |
What is the principle behind the use of surfactants? |
| A. | Reducing the size of solid drug particles |
| B. | Enhancing the dissolution rate by promoting wetting |
| C. | Improving solubility |
| D. | Alter the pH of the microenvironment |
| Answer» C. Improving solubility | |
| 615. |
…………decreases bioavailability of tetracycline. |
| A. | Lactose |
| B. | DCP |
| C. | Starch |
| D. | MCC |
| Answer» C. Starch | |
| 616. |
Which drug accumulate in adipose tissue? |
| A. | Arsenicals |
| B. | Tetracycline |
| C. | Halogenated hydrocarbons |
| D. | Lipophilic drug |
| Answer» E. | |
| 617. |
How pH alteration of the drug microenvironment is done? |
| A. | Altering the pH while the administration |
| B. | In situ salt formation |
| C. | Altering the pH of the tissue |
| D. | Formulating the drug in such a way that it gets activated only when it reaches the tissue pH |
| Answer» C. Altering the pH of the tissue | |
| 618. |
………….drug shows active tubular secretion. |
| A. | Penicillin |
| B. | Tetracycline |
| C. | Indomethacine |
| D. | None of the above |
| Answer» B. Tetracycline | |
| 619. |
Which of the following equations correct for Henderson-Hasselbach equation for weak bases? |
| A. | PH = pKa – log (Unionized drug concentration /Ionized drug concentration) |
| B. | PH = pKa – log (Ionized drug concentration/ Unionized drug concentration) |
| C. | PH = pKa + log (Ionized drug concentration/ Unionized drug concentration) |
| D. | PH = pKa + log (Unionized drug concentration /Ionized drug concentration) |
| Answer» E. | |
| 620. |
Which theory takes into account that a thin film is created by the solution of the solid at the solidliquid interface? |
| A. | Interfacial barrier model |
| B. | Diffusion layer model |
| C. | Penetration or surface renewal theory |
| D. | Danckwert’s model |
| Answer» C. Penetration or surface renewal theory | |
| 621. |
Which part of the membrane is responsible for the relative impermeability of polar molecules in andout of the cell? |
| A. | Polar head |
| B. | Hydrophobic head |
| C. | Hydrophobic core |
| D. | Non polar head |
| Answer» D. Non polar head | |
| 622. |
Pick out the parenteral route of medicinal agent administration: |
| A. | Rectal |
| B. | Oral |
| C. | Sublingual |
| D. | Inhalation |
| Answer» E. | |
| 623. |
Which of the following Factors causing Non-linearity? |
| A. | Nonlinearity may arise due to pathological alteration at any one of the various pharmacokinetic steps, such as absorption, distribution and/or elimination. |
| B. | Nonlinearity may arise due to Capacity-limited metabolism. |
| C. | Nonlinearity may arise due to alteration in protein binding characteristics |
| D. | All of the above |
| Answer» E. | |
| 624. |
The drugs which are most affected in pregnancy are those having |
| A. | Low protein binding and high Vd |
| B. | High protein binding and low Vd |
| C. | High protein binding and high Vd |
| D. | Low protein binding and low Vd |
| Answer» C. High protein binding and high Vd | |
| 625. |
Which of the following will not be a parameter that should be examined for urinary excretion data? |
| A. | (dXu/dt) max |
| B. | (tu)max |
| C. | Xu |
| D. | Cmax |
| Answer» E. | |
| 626. |
Which of the following will not be a factor governing the removal of substances through dialysis? |
| A. | Molecular weight |
| B. | Water solubility |
| C. | Disintegration time |
| D. | Protein binding |
| Answer» D. Protein binding | |
| 627. |
The main mechanism of most drugs absorption in GI tract is: |
| A. | Active transport (carrier-mediated diffusion) |
| B. | Filtration (aqueous diffusion) |
| C. | Endocytosis and exocytosis |
| D. | Passive diffusion (lipid diffusion) |
| Answer» E. | |
| 628. |
Which of the following drug is not stable in the gastric fluid? |
| A. | Erythromycin |
| B. | Paracetamol |
| C. | Salicylic acid |
| D. | none of the above |
| Answer» B. Paracetamol | |
| 629. |
A drug reverses plasma-protein binding is often referred as…….. |
| A. | displacer |
| B. | solvate |
| C. | carrier substance |
| D. | protein hydrolysate |
| Answer» B. solvate | |
| 630. |
Which drugs gets mostly absorbed from the mouth? |
| A. | Acidic drugs and lipophilic drugs |
| B. | Lipophilic drugs and neutral drugs |
| C. | Neutral drugs and lipophilic drugs |
| D. | Lipophilic, neutral, basic drugs |
| Answer» B. Lipophilic drugs and neutral drugs | |
| 631. |
The reasons determining bioavailability are….. |
| A. | Rheological parameters of blood |
| B. | Amount of a substance obtained orally and quantity of intakes |
| C. | Extent of absorption and hepatic first-pass effect |
| D. | Glomerular filtration rate |
| Answer» D. Glomerular filtration rate | |
| 632. |
What will bet the apparent volume of distribution of drugs which binds selectively to extravascular tissues? |
| A. | The apparent volume of distribution is less than the true volume of distribution |
| B. | The apparent volume of distribution is more than the true volume of distribution |
| C. | The apparent volume of distribution is equal to the true volume of distribution |
| D. | The apparent volume of distribution is equal to the volume of extravascular tissues |
| Answer» C. The apparent volume of distribution is equal to the true volume of distribution | |
| 633. |
Which one of these is correct Michaelis-Menten equation? |
| A. | –dC/dt = Vmax C/Km+C |
| B. | dC/dt = Vmax C/Km+C |
| C. | –dC/dt = Vmax C/Km |
| D. | –dC/dt = Km+C / Vmax C |
| Answer» B. dC/dt = Vmax C/Km+C | |
| 634. |
According to Biopharmaceutics Classification System (BCS), Class II drugs have |
| A. | High solubility/High permeability |
| B. | Low solubility /High permeability |
| C. | High solubility /Low permeability |
| D. | Low solubility /Low permeability |
| Answer» C. High solubility /Low permeability | |
| 635. |
What is the main role of the large intestine? |
| A. | Absorption of water and electrolytes |
| B. | Absorption of minerals |
| C. | Absorption of glucose |
| D. | Absorption of only water |
| Answer» B. Absorption of minerals | |
| 636. |
What will be the elimination rate if the clearance is 130ml/min and drug concentration is 0.8 g/ml? |
| A. | 104g/min |
| B. | 140g/min |
| C. | 130g/min |
| D. | 100g/min |
| Answer» B. 140g/min | |
| 637. |
……………is located at the sertoli-sertoli cell junction. |
| A. | Blood testis barrier |
| B. | Blood CSF barrier |
| C. | Blood cellular barrier |
| D. | All of the above |
| Answer» B. Blood CSF barrier | |
| 638. |
The Initial distribution of drug into the tissue is determined chiefly by |
| A. | Rate of blood flow to tissue |
| B. | Plasma protein binding of drug |
| C. | Affinity for tissue |
| D. | Gastric emptying time |
| Answer» B. Plasma protein binding of drug | |
| 639. |
Which one is the correct equation to calculate fraction of unbound drug in plasma? |
| A. | Concentration of unbound drug in plasma / total plasma concentration of drug |
| B. | Total plasma concentration of drug / Concentration of unbound drug in plasma |
| C. | 1/Concentration of unbound drug in plasma |
| D. | 1/total plasma concentration of drug |
| Answer» B. Total plasma concentration of drug / Concentration of unbound drug in plasma | |
| 640. |
………types of drugs are absorbed by pore transport mechanism. |
| A. | Macromolecules |
| B. | Ionic drugs |
| C. | Drugs with molecular weight 100-400 |
| D. | Water soluble drugs of molecular weight less than 100 |
| Answer» E. | |
| 641. |
Tubular reabsorption is achieved by…………… |
| A. | active process |
| B. | passive process |
| C. | Both (a) & (b) |
| D. | none of the above |
| Answer» D. none of the above | |
| 642. |
………………..is the manner in which a drug is taken. |
| A. | Dosage regimen |
| B. | Dosage volume |
| C. | Dosage loading |
| D. | None of the above |
| Answer» B. Dosage volume | |
| 643. |
…………………in lipophilicity increases the extend of binding. |
| A. | Increase |
| B. | Decrease |
| C. | Constant |
| D. | None of the above |
| Answer» B. Decrease | |
| 644. |
Which drugs results in distortion of double stranded DNA structure? |
| A. | Arsenicals |
| B. | Quinacrine |
| C. | Halogenated hydrocarbons |
| D. | Lipophilic drug |
| Answer» C. Halogenated hydrocarbons | |
| 645. |
How much time does an intravenously administered drug take to complete a complete circulation? |
| A. | 5-8 min |
| B. | 7-10 min |
| C. | 1-3 min |
| D. | 1 min |
| Answer» D. 1 min | |
| 646. |
Which one is the correct sequence for drug absorption through the oral route? |
| A. | Absorption – Dissolution – Disintegration – Deaggregation |
| B. | Disintegration – Dissolution – Deaggregation – Absorption |
| C. | Disintegration – Deaggregation – Dissolution – Absorption |
| D. | Disintegration – Deaggregation – Absorption – Dissolution |
| Answer» D. Disintegration – Deaggregation – Absorption – Dissolution | |
| 647. |
What is the name of the drug binding site IV of HSA? |
| A. | Tamoxifen binding site |
| B. | Digitoxin binding site |
| C. | Diazepam binding site |
| D. | Warfarin and azapropazone binding site |
| Answer» B. Digitoxin binding site | |
| 648. |
Which drugs cannot pass the Capillary endothelial Barrier? |
| A. | Molecular size less than 600 Dalton |
| B. | Drugs bound to blood components |
| C. | Drugs bound to a chemical moiety |
| D. | All drugs can pass |
| Answer» C. Drugs bound to a chemical moiety | |
| 649. |
Which of the following is known as Tamoxifen binding site? |
| A. | Site I |
| B. | Site II |
| C. | Site III |
| D. | Site IV |
| Answer» E. | |
| 650. |
Which one of the following sentences will be the actual definition of distribution? |
| A. | Transfer of drug from the administration dosage to surrounding fluid |
| B. | Transfer of drug from the surrounding the fluid to the blood |
| C. | Transfer of the drug from the oral cavity to the intestine |
| D. | Reversible tr |
| Answer» E. | |