MCQOPTIONS
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MCQOPTIONS
This section includes 925 Mcqs, each offering curated multiple-choice questions to sharpen your GPAT knowledge and support exam preparation. Choose a topic below to get started.
| 551. |
Select the formula to calculate elimination half life |
| A. | t1/2 = 0.693 + Ke |
| B. | t1/2 = 0.693 / Ke |
| C. | t1/2 = 0.693 × Ke |
| D. | t1/2 = 0.693 – Ke |
| Answer» C. t1/2 = 0.693 × Ke | |
| 552. |
Which of the following drugs can get distributed to the excess body space of obese patient? |
| A. | Phenytoin |
| B. | Caffeine |
| C. | Digoxin |
| D. | Antibiotics |
| Answer» E. | |
| 553. |
Therapeutic response is based on observing the clinical response to a drug formulation. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 554. |
Which of the following processes proceeds in the second phase of biotransformation? |
| A. | Acetylation |
| B. | Reduction |
| C. | Oxidation |
| D. | Hydrolysis |
| Answer» B. Reduction | |
| 555. |
Which kind of drugs are absorbed through endocytosis? |
| A. | Molecular weight ranging 100-400Dalton |
| B. | Water-soluble drugs |
| C. | Macromolecular drugs or drugs as oily droplets |
| D. | Polar drugs |
| Answer» D. Polar drugs | |
| 556. |
In meningitis and encephalitis polar antibiotics gain access to BBB which don’t happen to a healthyperson. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 557. |
The primary pharmacokinetic parameter clearance can be calculated by |
| A. | Cl = KV |
| B. | Cl = Dose/AUC |
| C. | Cl = (dA/dt)/C |
| D. | all of the above |
| Answer» E. | |
| 558. |
Which is the major rate-limiting step in the absorption of a drug from suspension dosage? |
| A. | Tablet disintegration to granules |
| B. | Granules disintegration to fine particles |
| C. | Fine particles dissolution |
| D. | Dissolution absorbed into the blood |
| Answer» D. Dissolution absorbed into the blood | |
| 559. |
Which of the following is not a physicochemical factor of drug that can affect the renal excretion? |
| A. | Molecular size |
| B. | Disintegration rate |
| C. | pKa of the drug |
| D. | Lipid solubility |
| Answer» C. pKa of the drug | |
| 560. |
All drugs which are weak acids or acidic in nature will be in a unionized form in the plasma. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 561. |
………………is the ratio of the mean residence time to the absorption time |
| A. | Absorption number |
| B. | Dissolution number |
| C. | Dose number |
| D. | Intrinsic dissolution |
| Answer» B. Dissolution number | |
| 562. |
Which one of the following bonds is not generally a bond through which a drug will bind in our body? |
| A. | Hydrogen bond |
| B. | Hydrophobic bond |
| C. | Ionic bond |
| D. | Covalent bond |
| Answer» E. | |
| 563. |
Which of the following is most likely to be associated with a high apparent volume of distribution |
| A. | High hepatic extraction ratio |
| B. | Penetration across the blood:brain and blood:testes barriers |
| C. | Extensive binding to plasma protein |
| D. | Extensive binding to tissue constituents |
| Answer» E. | |
| 564. |
Following intravenous administration, drugs are distributed fastest to: |
| A. | the skin, kidney, and brain |
| B. | the liver, kidney, and brain |
| C. | the liver, adipose, and brain |
| D. | the liver, kidney, and adipose |
| Answer» C. the liver, adipose, and brain | |
| 565. |
Which types of drugs get absorbed by ion-pair transport? |
| A. | High lipophilicity |
| B. | Oily droplets |
| C. | Affinity for carriers |
| D. | Drugs that ionize at all pH conditions |
| Answer» E. | |
| 566. |
Which drug easily bind to AAG? |
| A. | Cationic drug |
| B. | Anionic drug |
| C. | Lipophilic drug |
| D. | Neutral drug |
| Answer» B. Anionic drug | |
| 567. |
Which one of these is an example of Enteral Route? |
| A. | Skin |
| B. | IV |
| C. | Gastrointestinal |
| D. | Inhalation |
| Answer» D. Inhalation | |
| 568. |
Pick out the appropriate alimentary route of administration when passage of drugs through liver is minimized: |
| A. | Oral |
| B. | Transdermal |
| C. | Rectal |
| D. | Intraduodenal |
| Answer» D. Intraduodenal | |
| 569. |
What is the equation for biliary clearance? |
| A. | No such equation is there |
| B. | Biliary excretion rate/ plasma drug concentration |
| C. | Plasma drug concentration / biliary excretion rate |
| D. | Plasma drug concentration / Bile flow * biliary drug concentration |
| Answer» C. Plasma drug concentration / biliary excretion rate | |
| 570. |
The mathematical relationship between plasma drug concentration and pharmacological response iscalled as……….. |
| A. | PK modeling |
| B. | PD modeling |
| C. | PK-PD modeling |
| D. | None of the above |
| Answer» D. None of the above | |
| 571. |
Linear Pharmacokinetics also referred as…………. |
| A. | First-order kinetics |
| B. | Second order kinetics |
| C. | Pseudo order kinetics |
| D. | None of the above in |
| Answer» B. Second order kinetics | |
| 572. |
The agglomerative phase of the communication method grinds the drug in a ball mill for a long timeto affect spontaneous agglomeration. But results showed tablets produced are softer. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 573. |
Which one of the following is the correct order of the drugs binding to various plasma protein? |
| A. | Albumin > alpha-1 acid glycoprotein > globulins > lipoproteins |
| B. | Albumin > globulins > lipoproteins > alpha-1 acid glycoprotein |
| C. | Albumin > alpha-1 acid glycoprotein > lipoproteins > globulins |
| D. | Albumin > lipoproteins > globulins > alpha-1 acid glycoprotein |
| Answer» D. Albumin > lipoproteins > globulins > alpha-1 acid glycoprotein | |
| 574. |
Elimination is expressed as follows: |
| A. | Rate of renal tubular reabsorption |
| B. | Clearance speed of some volume of blood from substance |
| C. | Time required decreasing the amount of drug in plasma by one-half |
| D. | Clearance of an organism from a xenobiotic |
| Answer» E. | |
| 575. |
A drug solution has half life of 21 days. Assuming that drug undergoes first order kinetics, how long will it take for the potency to drop to 90% of initial potency? |
| A. | 3.2 days |
| B. | 9.6 days |
| C. | 16 days |
| D. | 6.2 days |
| Answer» B. 9.6 days | |
| 576. |
The total body water volume can be determined by using high molecular weight dyes. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 577. |
The process in which some drugs stimulate their own metabolism is known as |
| A. | Enzyme inhibition |
| B. | Autoinduction |
| C. | Product inhibition |
| D. | None of the above |
| Answer» C. Product inhibition | |
| 578. |
Which of the following is not a category of 2 compartment model? |
| A. | Two compartment model with elimination from the central compartment |
| B. | Two compartment model with elimination from the peripheral compartment |
| C. | Two compartment model with elimination from only plasma and blood |
| D. | Two compartment model with elimination from both the compartments |
| Answer» E. | |
| 579. |
When a drug is administered by the intravenous route then an absolute bioavailability will be |
| A. | 1 |
| B. | 0 |
| C. | 2 |
| D. | 3 |
| Answer» B. 0 | |
| 580. |
Which one of the following is used for selective adsorption on insoluble carriers of the drugs? |
| A. | Freeze drying |
| B. | Organic solvent |
| C. | Inorganic clays like bentonite |
| D. | Creating metastable polymorphs |
| Answer» D. Creating metastable polymorphs | |
| 581. |
On what basis the dose interval is calculated? |
| A. | Active drug concentration in the formulation |
| B. | Half-life of the drug |
| C. | Duration of the disease |
| D. | Age of the patient |
| Answer» C. Duration of the disease | |
| 582. |
Which law states that 'the rate of diffusion is proportional to both the surface area and concentrationdifference and is inversely proportional to the thickness of the membrane’? |
| A. | Fick's Law |
| B. | Avagadro's Law |
| C. | Hooke's Law |
| D. | Pascal's Law |
| Answer» B. Avagadro's Law | |
| 583. |
Which of the following is not an important parameter of plasma level time studies? |
| A. | Cmax |
| B. | Tax |
| C. | The area under the plasma level-time curve |
| D. | Steady state level |
| Answer» E. | |
| 584. |
A microclimate pH, different from the luminal pH exists at the membrane surface. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 585. |
In the sequence of events in the drug absorption from orally administered solid dosage, which onecomes at first? |
| A. | Disintegration |
| B. | Disaggregation |
| C. | Dissolution |
| D. | Absorption |
| Answer» B. Disaggregation | |
| 586. |
Poor bioavailability means poor aqueous solubility. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 587. |
What should be the molecular weight of the drug molecules so that they can easily pass through the membrane? |
| A. | 600-800 Dalton |
| B. | 500-600 Dalton |
| C. | 300-500 Dalton |
| D. | 200-400 Dalton |
| Answer» C. 300-500 Dalton | |
| 588. |
Comparison of the rate and extent of the absorption of drug from the formulation under study to thedata of a reference standard that is given intravenously is known as: |
| A. | Biopharmaceutics |
| B. | Relative bioavailability |
| C. | Absolute bioavailability |
| D. | Bioavailability |
| Answer» D. Bioavailability | |
| 589. |
Which one of these is an example of a strong acid drug? |
| A. | Diazepam |
| B. | Ibuprofen |
| C. | Cromolyn |
| D. | Aspirin |
| Answer» D. Aspirin | |
| 590. |
Which of the following is the half life of first order reaction? |
| A. | t1/2 = A0 / 2k |
| B. | t1/2 = 0.693 / 2k |
| C. | tl/2 = 2k |
| D. | tl/2 = 0.693 / k |
| Answer» E. | |
| 591. |
................mechanism is useful to describe charged or highly ionized drug molecules. |
| A. | Ion-pair transport |
| B. | Cellular transport |
| C. | Active transport |
| D. | Passive tr |
| Answer» B. Cellular transport | |
| 592. |
All of the following displace imipramine from protein binding site except |
| A. | Aspirin |
| B. | Phenytoin |
| C. | Ethosuximide |
| D. | Phenylbutazone |
| Answer» D. Phenylbutazone | |
| 593. |
Non-linear Pharmacokinetics also called as………… |
| A. | Mixed order |
| B. | Saturated kinetics |
| C. | Capacity Limited |
| D. | All of the above |
| Answer» E. | |
| 594. |
In infants, the gastric pH is quite low. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 595. |
What could be the reason that irrespective of pH any drug gets absorbed mostly from the intestine? |
| A. | More surface area |
| B. | Long residence time |
| C. | Large surface area and long residence time |
| D. | Large surface area, long residence time, basic pH |
| Answer» D. Large surface area, long residence time, basic pH | |
| 596. |
If the pH of either side of the membrane is different, then the compartment whose pH favoursgreater ionization will have less amount of drug. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 597. |
A multicompartment model assumes that all transfer rate processes for the passage of drug into or outof individual compartments are…………….. processes. |
| A. | First-order |
| B. | Second order |
| C. | Pseudo order |
| D. | None of the above |
| Answer» B. Second order | |
| 598. |
Absorption of griseofulvin is…………… |
| A. | Dissolution rate limited |
| B. | Permeation rate limited |
| C. | Perfusion rate limited |
| D. | None of the above |
| Answer» B. Permeation rate limited | |
| 599. |
What is the full form of PVP and what is its function in drug formation? |
| A. | Polyvinyl propylene, diluent |
| B. | Polyvinyl pyrrolidine, solubilizing agent |
| C. | Polyvinyl propylene, buffering agent |
| D. | Polyvinyl pyrrolidine, Binding agent |
| Answer» C. Polyvinyl propylene, buffering agent | |
| 600. |
The liver is the major site of drug metabolism. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |