MCQOPTIONS
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MCQOPTIONS
This section includes 925 Mcqs, each offering curated multiple-choice questions to sharpen your GPAT knowledge and support exam preparation. Choose a topic below to get started.
| 501. |
The value of association constant, Ka and the number of binding sites N can be obtained by |
| A. | Direct plot |
| B. | Scatchard plot |
| C. | Klotz plot |
| D. | All of the above |
| Answer» E. | |
| 502. |
Which of the following compounds are used as agents to determine Glomerular Filtration Rate? |
| A. | Calcium ion |
| B. | Albumin |
| C. | Creatinine |
| D. | Calcium carbonate |
| Answer» D. Calcium carbonate | |
| 503. |
Glomerular filtration rate would be increased by |
| A. | constriction of the afferent arteriole |
| B. | decrease in afferent arteriolar pressure |
| C. | compression of the renal capsule |
| D. | decrease in the concentration of plasma protein |
| Answer» E. | |
| 504. |
It is defined as the distribution of a drug between plasma and the rest of the body after oral orparenteral dosing. |
| A. | Volume of distribution (VD) |
| B. | Apparent volume of drug distribution |
| C. | Phagocytosis |
| D. | None of the above |
| Answer» C. Phagocytosis | |
| 505. |
The passage from the stomach to the small intestine is called gastric emptying. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 506. |
Which of the following is not a characteristic of the caternary compartment model? |
| A. | It gives a visual representation of various rate processes in drug disposition |
| B. | It shows how many rate constants are necessary |
| C. | Compartments and parameters bear a relationship with physiologic functions |
| D. | Useful in predicting drug |
| Answer» D. Useful in predicting drug | |
| 507. |
Choose the drug type for which microsomal oxidation is the most prominent. |
| A. | Water soluble |
| B. | Lipid soluble |
| C. | High molecular weight |
| D. | Low molecular weight |
| Answer» C. High molecular weight | |
| 508. |
What should be the range of oil/water partition coefficient of any drug? |
| A. | 1-2 |
| B. | 3-4 |
| C. | 2-3 |
| D. | 1-3 |
| Answer» B. 3-4 | |
| 509. |
...................is composed of highly perfused tissues, extracellular fluid, and blood with rapid anduniform drug distribution. |
| A. | Central compartment |
| B. | Peripheral compartment |
| C. | both of the above |
| D. | None of the above |
| Answer» B. Peripheral compartment | |
| 510. |
What is the name of the drug binding site III of HSA? |
| A. | Tamoxifen binding site |
| B. | Digitoxin binding site |
| C. | Diazepam binding site |
| D. | Warfarin and azapropazone binding site |
| Answer» C. Diazepam binding site | |
| 511. |
The characteristic of non-linear pharmacokinetics include………….. |
| A. | Area under the curve is proportional to the dose |
| B. | Elimination half-life remains constant |
| C. | Area under the curve is not proportional to the dose |
| D. | Amount of drug excreted through remains constant |
| Answer» D. Amount of drug excreted through remains constant | |
| 512. |
Low molecular weight of drugs have |
| A. | Low Vd |
| B. | high Vd |
| C. | No Vd |
| D. | none of the above |
| Answer» C. No Vd | |
| 513. |
Absolute surface area is proportional to the dissolution rate of a drug. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 514. |
For the calculation of the volume of distribution (Vd) one must take into account: |
| A. | Concentration of substance in urine |
| B. | Therapeutical width of drug action |
| C. | A daily dose of drug |
| D. | Concentration of a substance in plasma |
| Answer» E. | |
| 515. |
Non-invasive measurement of drug concentration includes ……….sampling. |
| A. | hair |
| B. | urine |
| C. | saliva |
| D. | All of the above |
| Answer» E. | |
| 516. |
What would be the order of greater or lesser bioavailability of the dosage forms? |
| A. | Intravenous > rectal > oral > topical |
| B. | Intravenous > oral > rectal > topical |
| C. | Intravenous > topical > rectal > oral |
| D. | Oral > intravenous > rectal > topical |
| Answer» C. Intravenous > topical > rectal > oral | |
| 517. |
Drugs of molecular range 300-500 Dalton will be excreted out by glomerulus. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 518. |
Bioavailability of an intravenous drug is always 100% by definition because: |
| A. | Bioavailability measures the amount of substance that reaches the bloodstream. |
| B. | Absolute bioavailability is 50%, for any drug taken intravenously |
| C. | Absolute bioavailability is a much more important measure than relative bioavailability |
| D. | Intravenous administration gets the drug into your bloodstream the fastest. |
| Answer» E. | |
| 519. |
The time period for which the plasma concentration of drug remains above minimum effective concentration is known as ______________ |
| A. | Onset of time |
| B. | Onset of action |
| C. | Duration of drug of action |
| D. | Therapeutic range |
| Answer» D. Therapeutic range | |
| 520. |
What helps the ionized drug molecules to pass through the cell membrane passively? |
| A. | Different pH |
| B. | Polar group |
| C. | Large lipophilic group |
| D. | Hydration |
| Answer» D. Hydration | |
| 521. |
Acidic drugs like imipramine, lidocaine bind to alpha 1 Acid Glycoprotein. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 522. |
A drug can be absorbed by more than one mechanism. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 523. |
Plasma Protein binding …………..the volume of distribution of drugs. |
| A. | increases |
| B. | decreases |
| C. | no change |
| D. | none of the above |
| Answer» C. no change | |
| 524. |
What is the pH range of the stomach? |
| A. | 1-4 |
| B. | 5-8 |
| C. | 1-3 |
| D. | 1-8 |
| Answer» D. 1-8 | |
| 525. |
Which of the following drugs are lipid soluble? |
| A. | Phenytoin |
| B. | Caffeine |
| C. | Digoxin |
| D. | Antibiotics |
| Answer» B. Caffeine | |
| 526. |
…………..it is the extent to which a drug will accumulate relative to the first dose can be quantifiedby an accumulation factor R. |
| A. | Accumulation Index |
| B. | Apparent volume of drug distribution |
| C. | Accumulation factor |
| D. | None of the above |
| Answer» B. Apparent volume of drug distribution | |
| 527. |
What does "pharmacokinetics" includes? |
| A. | Mechanisms of drug action |
| B. | Localization of drug action |
| C. | Interaction of substances |
| D. | Excretion of substances |
| Answer» E. | |
| 528. |
In noncompartmental analysis, Mean residence time is equal to _____________ |
| A. | The area under the first moment curve/area under the zero moment curve |
| B. | The area under the zero moment’s curve/area under the first moment curve |
| C. | 1 / Area under the first-moment curve |
| D. | 1/ Area under the zero moment curve |
| Answer» B. The area under the zero moment’s curve/area under the first moment curve | |
| 529. |
What is pH? |
| A. | –ve log of H+ concentration |
| B. | +ve log of H+ concentration |
| C. | Log of H+ concentration |
| D. | H+ concentration |
| Answer» B. +ve log of H+ concentration | |
| 530. |
Which form of a drug has greater solubility? |
| A. | Anhydrous |
| B. | Hydrate |
| C. | Crystallised |
| D. | Monohydrate |
| Answer» B. Hydrate | |
| 531. |
Constant rate infusion is…….. |
| A. | prevents fluctuations |
| B. | useful when drug has narrow TI |
| C. | Both (a) & (b) |
| D. | none of the above |
| Answer» D. none of the above | |
| 532. |
Clearance is inversely related to volume of distribution. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 533. |
Which of the following process drug moves from site of administration to systemic circulation? |
| A. | excretion |
| B. | absorption |
| C. | distribution |
| D. | metabolism |
| Answer» C. distribution | |
| 534. |
If drug administered by Intravenous route appears in feaces, it implies that the drug |
| A. | Undergo first pass metabolism |
| B. | Undergoes enterohepatic recycling |
| C. | It is not completely absorbed |
| D. | It is not completely metabolized |
| Answer» C. It is not completely absorbed | |
| 535. |
Which option describes the function of the enteric coated drug? |
| A. | Tough dissolves slowly |
| B. | Thin dissolves completely |
| C. | Dissolves only in alkaline pH of the intestine |
| D. | Shellac coating |
| Answer» C. Dissolves only in alkaline pH of the intestine | |
| 536. |
Active processes which are Saturable in renal excretion of drug includes……. |
| A. | Active tubular secretion |
| B. | Active tubular reabsorption |
| C. | Both of the above |
| D. | None of the above |
| Answer» D. None of the above | |
| 537. |
Protein binding of acidic drugs decreased in……….. |
| A. | Trauma |
| B. | Surgery |
| C. | Hepatic Cirrhosis |
| D. | Burns |
| Answer» B. Surgery | |
| 538. |
Which of the following will be an example of an organic suspending agent? |
| A. | CMC |
| B. | MC |
| C. | Acacia |
| D. | Carbowaxes |
| Answer» D. Carbowaxes | |
| 539. |
What is the pH of the milk secreted by human mothers? |
| A. | 6.4-7.6 |
| B. | 5.4-6.6 |
| C. | 7-8 |
| D. | 6-7 |
| Answer» B. 5.4-6.6 | |
| 540. |
The term bioavailability refers to the…………. |
| A. | relationship between the physical and chemical properties of a drug and the systemic absorption of the drug |
| B. | measurement of the rate and amount of therapeutically active drug that reaches the systemic circulation |
| C. | movement of drug into the body tissues over time |
| D. | dissolution of a drug in the gastrointestinal tract |
| Answer» C. movement of drug into the body tissues over time | |
| 541. |
Which of the following strategies are widely used to improve or promote transport of drug to brain? |
| A. | Glycosylation |
| B. | Use of Mannitol |
| C. | Prodrug approach |
| D. | All of the above |
| Answer» E. | |
| 542. |
Biological Half life equation for first order process is |
| A. | t1/2 = a/2K |
| B. | t1/2 = 0.693/K |
| C. | ) t1/2 = 1/aK |
| D. | ) t1/2 = 3/2 K |
| Answer» C. ) t1/2 = 1/aK | |
| 543. |
Movement of drug across the membrane is called as |
| A. | Symport |
| B. | Antiport |
| C. | Drug transport |
| D. | Absorption |
| Answer» D. Absorption | |
| 544. |
Acidic drug have |
| A. | Low Vd |
| B. | high Vd |
| C. | No Vd |
| D. | none of the above |
| Answer» B. high Vd | |
| 545. |
Protein binding ……………the distribution of drugs. |
| A. | Decreases |
| B. | Increases |
| C. | No Change |
| D. | none of the above |
| Answer» B. Increases | |
| 546. |
Particle size and surface area of a drug are directly related to each other. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 547. |
Renal excretion of drug depend on |
| A. | urine flow |
| B. | pH of urine |
| C. | Physicochemical properties of drug |
| D. | All of above |
| Answer» E. | |
| 548. |
How a patient’s plasma volume can be determined? |
| A. | Evans blue |
| B. | Na+ |
| C. | D20 |
| D. | Tritiated water |
| Answer» B. Na+ | |
| 549. |
What is bioequivalence? |
| A. | Drug substance reaches the systemic circulation at the same rate in two or more identical dosage |
| B. | Two or more drug products contain the same labeled chemical substance in different quantity |
| C. | Two or more drug products contain different labeled chemical substance giving the same therapeutic effect |
| D. | Two or more drug products contain the same labeled chemical substance giving a different therapeutic effect |
| Answer» B. Two or more drug products contain the same labeled chemical substance in different quantity | |
| 550. |
What influences the permeation of drugs in an Ionic or Electrochemical diffusion? |
| A. | Charge on the membrane |
| B. | Charge on the particle |
| C. | Concentration gradient |
| D. | Equilibration of charge |
| Answer» B. Charge on the particle | |