Which of the following is correct statement about Nonlinear pharmacokinetics?

• A. The pharmacokinetic parameters of a drug will not change when multiple doses of drug are administered
• B. The graph of the relationship between the different factors involved (dose, blood plasma concentrations, elimination, etc.) gives a straight line.
• C. the plasma drug concentration changes either more or less than would be expected from a change in dose rate.
• D. None of the above