MCQOPTIONS
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MCQOPTIONS
This section includes 925 Mcqs, each offering curated multiple-choice questions to sharpen your GPAT knowledge and support exam preparation. Choose a topic below to get started.
| 851. |
Which of the following is not highly protein bound drug |
| A. | Barbiturates |
| B. | Phenylbutazone |
| C. | Salicylates |
| D. | Aspirin |
| Answer» E. | |
| 852. |
Passive diffusion is expressed by |
| A. | Fick's first law of diffusion |
| B. | Fick's second law of diffusion |
| C. | First order kinetics |
| D. | zero order kinetics |
| Answer» B. Fick's second law of diffusion | |
| 853. |
Capsules with bigger particles and intense packing have poor drug release and dissolution rate due toan increase in the pore size. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 854. |
Which of the following promotes the excretion of basic drugs? |
| A. | Tartarates |
| B. | Citrates |
| C. | Bicarbonates |
| D. | Ammonium chloride |
| Answer» E. | |
| 855. |
Which of following drug shows non-linearity in hepatic excretion? |
| A. | Carbamazepine |
| B. | Propranolol |
| C. | Penicillin |
| D. | Thiopental |
| Answer» B. Propranolol | |
| 856. |
The constants that represent reversible transfer of drug between compartments are called as |
| A. | microconstants |
| B. | macroconstant |
| C. | Infusion |
| D. | Lag time |
| Answer» B. macroconstant | |
| 857. |
Which one of these is not a theory of Drug dissolution? |
| A. | Diffusion layer model |
| B. | Fick’s law of diffusion |
| C. | Penetration or surface renewal theory |
| D. | Interfacial barrier model |
| Answer» C. Penetration or surface renewal theory | |
| 858. |
Factors altering the binding of the drug to the blood increases the volume of distribution of the drug and the factors that influence drug binding to the extravascular component decreases the volume of distribution. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 859. |
What is the equation for clearance? |
| A. | Elimination rate / plasma drug concentration |
| B. | Plasma drug concentration/elimination rate |
| C. | 1 / Plasma drug concentration |
| D. | 1 / Elimination rate |
| Answer» B. Plasma drug concentration/elimination rate | |
| 860. |
Which creatinine clearance value shows moderate renal failure? |
| A. | 120-130 ml/min |
| B. | 20-50 ml/min |
| C. | Below 10 ml/min |
| D. | 70-80 ml/min |
| Answer» C. Below 10 ml/min | |
| 861. |
If distribution of drug is slower than process of biotransformation and elimination |
| A. | It will cause high blood level of drug |
| B. | It will cause low blood level of drug |
| C. | Cause failure to attain diffusion equilibrium |
| D. | None of the above |
| Answer» D. None of the above | |
| 862. |
Single-dose bioavailability studies are simple and common. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 863. |
Vehicles are the solvent system for the liquefied drug. Which one of them is not an example of akind of vehicle? |
| A. | Aqueous vehicle |
| B. | Non-aqueous water-miscible vehicles |
| C. | Non-aqueous water immiscible vehicles |
| D. | A salt solution of the drug |
| Answer» E. | |
| 864. |
Which of these absorption methods involves engulfing of the extracellular drug? |
| A. | Endocytosis |
| B. | Passive diffusion |
| C. | Facilitated diffusion |
| D. | Ion-Pair tr |
| Answer» B. Passive diffusion | |
| 865. |
Which one of the below does not belong to the 4 classes of lipoprotein? |
| A. | Chylomicrons |
| B. | Very low-density lipoproteins |
| C. | High-density lipoprotein |
| D. | Fatty acids |
| Answer» E. | |
| 866. |
Which metals get accumulated in kidney? |
| A. | Mercury, cadmium, lead |
| B. | Mercury, cadmium, iron |
| C. | Mercury, lanthanum, lead |
| D. | Mercury, cadmium, fluoride ions |
| Answer» B. Mercury, cadmium, iron | |
| 867. |
PABA complex is used for the enhancement of ______________ |
| A. | Enhanced chelation |
| B. | Enhanced dissolution |
| C. | Enhanced membrane permeability |
| D. | Enhanced lipophilicity |
| Answer» E. | |
| 868. |
What should be the ideal solubility rate of an orally administered drug in the pH range of 2 to 8? |
| A. | 3-4mg/ml |
| B. | 4-6 mg/ml |
| C. | 7-8 mg/ml |
| D. | 1-2 mg/ml |
| Answer» E. | |
| 869. |
Neonates, infants and children require different dosages than adults. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 870. |
What is the driving force for glomerular filtration? |
| A. | Concentration gradient |
| B. | Hydrostatic pressure of plasma |
| C. | High amount of aqueous pores |
| D. | Hydrostatic pressure of blood flow |
| Answer» E. | |
| 871. |
…………………it is the extent to which a drug will accumulate relative to the first dose can bequantified by an accumulation factor R. |
| A. | Accumulation Index |
| B. | Apparent volume of drug distribution |
| C. | Accumulation factor |
| D. | None of the above |
| Answer» B. Apparent volume of drug distribution | |
| 872. |
How do you calculate the rate of excretion by kidneys? |
| A. | Rate of filtration – the rate of secretion – Rate of absorption |
| B. | Rate of filtration + rate of secretion – Rate of absorption |
| C. | Rate of filtration + rate of secretion + Rate of absorption |
| D. | Rate of filtration – the rate of secretion + Rate of absorption |
| Answer» C. Rate of filtration + rate of secretion + Rate of absorption | |
| 873. |
The concentration of colorant does not affect the drug solubility. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 874. |
Which drugs cannot be filtered through glomerulus? |
| A. | Drugs bound to plasma proteins |
| B. | Unbound |
| C. | Free drug |
| D. | Below molecular weight of 300 Dalton |
| Answer» B. Unbound | |
| 875. |
Which one will be the easiest approach to enhance the solubility and dissolution of any drug? |
| A. | Micronize the drug |
| B. | Convert drug into their anhydrous form |
| C. | Convert drug into their hydrous form |
| D. | Convert drug into their salt form |
| Answer» E. | |
| 876. |
The i.v. bolus dosage is 500mg and the plasma drug concentration is 0.8 mg/ml. What should be the volume of distribution? |
| A. | 625 mg/ml |
| B. | 625 l |
| C. | 625 ml |
| D. | 0.0016 mg/ml |
| Answer» D. 0.0016 mg/ml | |
| 877. |
Drugs in patients with renal impairment have same pharmacokinetic profile as in a person withoutrenal failure. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 878. |
Creatinine clearance is used as measurement for |
| A. | Glomerular filtration rate |
| B. | Renal excretion rate |
| C. | Passive renal excretion |
| D. | Drug metabolism rate |
| Answer» B. Renal excretion rate | |
| 879. |
Penicillin has short plasma half-life although it can bind to plasma protein rigidly. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 880. |
Which one of the following is the buccal route? |
| A. | Drug placed between cheek and gum |
| B. | Drug place between the tongue and upper palate |
| C. | Drug placed under the tongue |
| D. | Drug crushed and placed under the tongue |
| Answer» B. Drug place between the tongue and upper palate | |
| 881. |
From the below options which will be the most widely used form of dosage? |
| A. | Emulsion |
| B. | Solutions |
| C. | Tablets |
| D. | Powders |
| Answer» B. Solutions | |
| 882. |
In passive diffusion, the transport of drugs takes place from a region of ……………concentration to a ……………..concentration. |
| A. | Lower, Higher |
| B. | Higher, Lower |
| C. | Both (a) and (b) |
| D. | none of the above |
| Answer» C. Both (a) and (b) | |
| 883. |
What happens when an obese person is given with a lipophilic drug? |
| A. | Drug aggregation will begin |
| B. | He cannot absorb lipophilic drugs |
| C. | High adipose tissue take up most of the lipophilic drug |
| D. | A large amount of drug is needed as the person’s weight is more |
| Answer» D. A large amount of drug is needed as the person’s weight is more | |
| 884. |
Which one of the following has very low perfusion rate? |
| A. | Fat and bone |
| B. | Muscle and skin |
| C. | Lungs and kidney |
| D. | Liver and Heart |
| Answer» B. Muscle and skin | |
| 885. |
Conjugation of a drug includes the following except: |
| A. | Glucuronidation |
| B. | Sulfate formation |
| C. | Hydrolysis |
| D. | Methylation |
| Answer» D. Methylation | |
| 886. |
In the equation, V dC/dt = dm/dt = A(Cs-Cb).√ γ D, what does γ stands for? |
| A. | Mass of the solid dissolved |
| B. | Rate of surface renewal |
| C. | Concentration of solute |
| D. | Concentration of the drug |
| Answer» C. Concentration of solute | |
| 887. |
The deleterious effect of various coatings on drug dissolution is shown in orders below. Which oneof them is the correct order? |
| A. | Enteric coat > sugar coat > nonenteric film coat |
| B. | Enteric coat > nonenteric film coat > sugar coat |
| C. | Nonenteric film coat > sugar coat > enteric coat |
| D. | Sugar coat > enteric coat > nonenteric film coat |
| Answer» B. Enteric coat > nonenteric film coat > sugar coat | |
| 888. |
Proteins interact with which part of the cell membrane? |
| A. | Hydrophobic tail |
| B. | Polar head |
| C. | Non polar head |
| D. | Hydrophilic tail |
| Answer» B. Polar head | |
| 889. |
In two compartment model, extravascular route of drug administration, there are ……phases |
| A. | absorption phase, |
| B. | Distribution phase |
| C. | elimination phase, |
| D. | All of the above |
| Answer» E. | |
| 890. |
To have a plasma distribution value of 900 ml and plasma drug concentration to be 1.2 mg/ml what should be the amount of drug that should be given to the patient? |
| A. | 1080 ml |
| B. | 1080 g |
| C. | 1080 mg |
| D. | 1g/ml |
| Answer» D. 1g/ml | |
| 891. |
Suspending agent and some sugars can be used as viscosity imparters. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 892. |
The amount of drug in the body is directly proportional to the concentration of the drug in plasma. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 893. |
Which one of these is not an approach to make the drug cross the blood-brain barrier? |
| A. | Using permeation enhancers |
| B. | Osmotic disruption of the blood-brain barrier |
| C. | Use of highly lipophilic drug only |
| D. | Use of drug carriers to cross the BBB |
| Answer» D. Use of drug carriers to cross the BBB | |
| 894. |
Which of the following creates nonlinearity in drug distribution and not in drug absorption? |
| A. | When absorption is solubility or dissolution rate-limited |
| B. | When absorption involves carrier-mediated transport systems |
| C. | When a presystemic gut wall or hepatic metabolism attains saturation |
| D. | Saturation of binding sites on plasma proteins |
| Answer» E. | |
| 895. |
Which one of these is not an advantage of buffered aspirin tablets? |
| A. | Enhanced bioavailability |
| B. | Reduced gastric irritation |
| C. | Increased stability |
| D. | Increased ulcerogenic tendency |
| Answer» E. | |
| 896. |
Pharmacokinetics is: |
| A. | The study of absorption, distribution, metabolism and excretion of drugs |
| B. | The study of biological and therapeutic effects of drugs |
| C. | The study of methods of new drug development |
| D. | The study of mechanisms of drug action |
| Answer» B. The study of biological and therapeutic effects of drugs | |
| 897. |
Acidic drugs are best absorbed through the stomach and basic drugs are best absorbed through theintestine. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 898. |
Infants have high albumin content. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 899. |
Biotransformation of the drugs is to render them: |
| A. | Less lipid soluble |
| B. | More lipid soluble |
| C. | More pharmacologically active |
| D. | Less ionized |
| Answer» B. More lipid soluble | |
| 900. |
Elimination after 4 half lives in first order kinetics is |
| A. | 84% |
| B. | 93% |
| C. | 80% |
| D. | 4% |
| Answer» C. 80% | |