MCQOPTIONS
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MCQOPTIONS
This section includes 925 Mcqs, each offering curated multiple-choice questions to sharpen your GPAT knowledge and support exam preparation. Choose a topic below to get started.
| 451. |
…………is the tight junction between sertoli cells. |
| A. | BBB |
| B. | placental barrier |
| C. | blood-testis barrier |
| D. | endothelial barrier |
| Answer» D. endothelial barrier | |
| 452. |
Total body clearance is |
| A. | the drug elimination rate divided by the plasma drug concentration |
| B. | the drug elimination rate divided by the Vd |
| C. | the amount of drug in body divided by the plasma drug concentration |
| D. | None of the above |
| Answer» B. the drug elimination rate divided by the Vd | |
| 453. |
Under non compartment analysis the following formula is used for calculation |
| A. | MRT = AUMC / AUC |
| B. | AUMC = MRT / AUC |
| C. | MRT = AUC / AUMC |
| D. | AUC = AUMC / MRT |
| Answer» B. AUMC = MRT / AUC | |
| 454. |
Aqueous filled pores present in cell membrane responsible for absorption of |
| A. | water insoluble molecules |
| B. | water soluble molecules |
| C. | both (a) and (b) |
| D. | None of the above |
| Answer» C. both (a) and (b) | |
| 455. |
Linear Pharmacokinetics is……………… |
| A. | Dose dependent |
| B. | Dose independent |
| C. | Both of the above |
| D. | None of the above |
| Answer» B. Dose independent | |
| 456. |
What is the name of the drug binding site II of HSA? |
| A. | Tamoxifen binding site |
| B. | Digitoxin binding site |
| C. | Diazepam binding site |
| D. | Warfarin and azapropazone binding site |
| Answer» D. Warfarin and azapropazone binding site | |
| 457. |
tmax indicates |
| A. | drug absorption rate |
| B. | drug elimination rate |
| C. | drug distribution rate |
| D. | drug metabolism rate |
| Answer» B. drug elimination rate | |
| 458. |
What is the driving force for Passive Diffusion? |
| A. | Concentration gradient only |
| B. | Electrochemical gradient only |
| C. | Charge equilibration and concentration gradient |
| D. | Concentration and Electrochemical gradient both |
| Answer» E. | |
| 459. |
What is the molecular weight cut off for biliary excretion? |
| A. | Less than 300 Dalton |
| B. | More than 300 Dalton |
| C. | Less than 200 Dalton |
| D. | More than 200 Dalton |
| Answer» C. Less than 200 Dalton | |
| 460. |
……………composed of groups of tissues with lower blood perfusion and different affinitythe drug with slow drug distribution. |
| A. | Central compartment |
| B. | Peripheral compartment |
| C. | Both of the above |
| D. | None of the above |
| Answer» C. Both of the above | |
| 461. |
…………..is nothing but manner in which drug should be taken. |
| A. | dosing frequency |
| B. | dosage regimen |
| C. | dose adjustment |
| D. | none of the above |
| Answer» C. dose adjustment | |
| 462. |
In compartment modeling the term "Open" indicates |
| A. | Unidirectional input and output |
| B. | All compartments are open |
| C. | Body is open |
| D. | None of the above |
| Answer» B. All compartments are open | |
| 463. |
Transfer of an endocytic vesicle from one extracellular compartment to another is known as |
| A. | Phagocytosis |
| B. | Transcytosis |
| C. | Pinocytosis |
| D. | Endocytosis |
| Answer» C. Pinocytosis | |
| 464. |
USP dissolution test apparatus type-II is also called as….. |
| A. | Hansen paddle type |
| B. | paddle over disc |
| C. | Rotating basket type |
| D. | none of the above |
| Answer» B. paddle over disc | |
| 465. |
Which of the following is carrier mediated transport system |
| A. | passive diffusion |
| B. | active transport |
| C. | pore transport |
| D. | none of the above |
| Answer» C. pore transport | |
| 466. |
What does the word “open” mean in the one compartment open model? |
| A. | The drug easily enters |
| B. | The drug readily mixes with the blood |
| C. | Unidirectional input and output |
| D. | Easy absorption |
| Answer» D. Easy absorption | |
| 467. |
Half life (t1/2) does not depend on: |
| A. | biotransformation |
| B. | time of drug absorption |
| C. | concentration of a drug in plasma |
| D. | rate of drug elimination |
| Answer» C. concentration of a drug in plasma | |
| 468. |
Nephron is functional unit of………….. |
| A. | Kidney |
| B. | Heart |
| C. | Lung |
| D. | Liver |
| Answer» B. Heart | |
| 469. |
Following is the order in decreasing order of drug binding to the extravascular tissue. Which one isthe correct order? |
| A. | Liver > kidney > muscle > lung |
| B. | Liver > muscle > lung > kidney |
| C. | Liver > muscle > kidney > lung |
| D. | Liver > kidney > lung > muscle |
| Answer» E. | |
| 470. |
Which one of the following is a critical rate-limiting step of drug absorption? |
| A. | Rate of drug disintegration |
| B. | Size of the drug |
| C. | Size of the porous particle |
| D. | Rate of dissolution |
| Answer» E. | |
| 471. |
Up to how much the microvilli in the small intestine increases the relative surface area of the smallintestine? |
| A. | 3 times |
| B. | 30 times |
| C. | 100 times |
| D. | 600 times |
| Answer» E. | |
| 472. |
Which one is the sublingual route? |
| A. | Drug placed between cheek and gum |
| B. | Drug place between the tongue and upper palate |
| C. | Drug placed under the tongue |
| D. | Drug crushed and placed under the tongue |
| Answer» D. Drug crushed and placed under the tongue | |
| 473. |
What is gastric emptying rate? |
| A. | The time required for the gastric contents to empty into the small intestine |
| B. | Time is taken for half of the contents in the stomach to empty |
| C. | The speed at which the stomach contents empty into the intestine |
| D. | There is no such term |
| Answer» D. There is no such term | |
| 474. |
Gastrointestinal route is an example of which of the major drug delivery routes? |
| A. | The enteral route |
| B. | The parenteral route |
| C. | The topical route |
| D. | The intravenous route |
| Answer» B. The parenteral route | |
| 475. |
The Binding Order of drug to tissue is………………… |
| A. | Kidney > Liver > Lungs > Muscle |
| B. | Muscle > Kidney > Lungs > Liver |
| C. | Liver > Kidney > Lungs > Muscle |
| D. | Liver > Lungs > Kidney > Muscle |
| Answer» D. Liver > Lungs > Kidney > Muscle | |
| 476. |
The drugs having molecular size …………..easily cross capillary membrane. |
| A. | <500-600d |
| B. | < 100-200 d |
| C. | <300-600d |
| D. | <90M600d |
| Answer» B. < 100-200 d | |
| 477. |
Which type of drug cannot enter the cell membrane in the below picture? |
| A. | Ionized drug |
| B. | Unionized drug |
| C. | Hydrolyzed drug |
| D. | Unhydrated drug |
| Answer» B. Unionized drug | |
| 478. |
How will you determine the intracellular fluid volume? |
| A. | Evans blue |
| B. | Na+ |
| C. | Difference between total body water and ECF volume |
| D. | Tritiated water |
| Answer» D. Tritiated water | |
| 479. |
What is bioavailability? |
| A. | The time of absorption of the drug from its dosage form |
| B. | The rate of absorption of the unchanged drug from its dosage form |
| C. | The time of absorption of the unchanged drug from its dosage form |
| D. | The rate of absorption of the drug from its dosage form |
| Answer» C. The time of absorption of the unchanged drug from its dosage form | |
| 480. |
The procedure of transporting a drug from the bloodstream to tissues is called as |
| A. | Absorption |
| B. | Dissolution |
| C. | Distribution |
| D. | Elimination |
| Answer» D. Elimination | |
| 481. |
Accumulation occurs because drug from previous doses was not being removed completely. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 482. |
What will be the rate of filtration if the rate of secretion is 0.9 ml/ sec, rate of reabsorption is 0.2 ml/sec and the rate of excretion is 2ml/sec for a particular drug? |
| A. | 3ml/sec |
| B. | 0.3ml/sec |
| C. | 1ml/sec |
| D. | 1.3ml/sec |
| Answer» E. | |
| 483. |
In which of the model peripheral compartments are connected to a central compartment? |
| A. | Compartment model |
| B. | Caternary model |
| C. | Physiologic model |
| D. | Mammillary model |
| Answer» E. | |
| 484. |
Which one of the following sentences depicts the function of Disintegrants correctly? |
| A. | These agents help in holding the powders together to form granules |
| B. | These agents overcome the cohesive strength of the tablets and help in dissolution |
| C. | These agents help in the flow of granules and reduce friction between particles |
| D. | Added when the required dosage is inadequate |
| Answer» C. These agents help in the flow of granules and reduce friction between particles | |
| 485. |
What will be the renal clearance ratio of a drug whose renal clearance is 40ml/min and the clearanceof creatinine is 95ml/min? |
| A. | 0.421 |
| B. | 2.38 |
| C. | 0.010 |
| D. | 0.025 |
| Answer» B. 2.38 | |
| 486. |
Which of these is not a characteristic of tablet formulation by Agglomerative phase of the communication process? |
| A. | Tablets are stronger |
| B. | Usage of more binding agent |
| C. | Rapid dissolution |
| D. | Increase in internal surface area of the granules |
| Answer» C. Rapid dissolution | |
| 487. |
Which of the following is not a limitation granulation? |
| A. | Formation of crystal bridge by the presence of liquid |
| B. | The liquid may act as a medium for affecting chemical reactions such as hydrolysis |
| C. | Increase the cost due to more additional processing |
| D. | The drying step may harm the thermolabile drugs |
| Answer» D. The drying step may harm the thermolabile drugs | |
| 488. |
From the surface of villi protrude smaller projection known as __________ |
| A. | Microvilli |
| B. | Villus |
| C. | Fingers |
| D. | Cilia |
| Answer» B. Villus | |
| 489. |
According to pH partition theory, a weak acidic drug will most likely be absorbed from the stomachbecause the drug which exist primarily in the |
| A. | Unionized, more lipid soluble form |
| B. | Ionised, more water soluble form |
| C. | Form of weak acid and more soluble in acid media |
| D. | Ionic form of the drug, which facilitates diffusion |
| Answer» B. Ionised, more water soluble form | |
| 490. |
Which coating is thin and dissolves rapidly? |
| A. | Sugar coating |
| B. | Film coating |
| C. | Enteric coating |
| D. | Sealing coating |
| Answer» C. Enteric coating | |
| 491. |
In Michaelis-Menton Equation, When the value of Km = C |
| A. | rate of process is half (1 /2) the maximum rate. |
| B. | the elimination of most drugs follows first order kinetic |
| C. | the elimination of most drugs follows zero order kinetic |
| D. | the elimination of most drugs follows second order kinetic |
| Answer» B. the elimination of most drugs follows first order kinetic | |
| 492. |
Which of the following forms inclusion complex and improves aqueous solubility and dissolution rate? |
| A. | Cyclodextrins |
| B. | PEG |
| C. | PVT |
| D. | Poloxamer |
| Answer» B. PEG | |
| 493. |
How is renal clearance expressed mathematically? |
| A. | Rate of urinary excretion/plasma drug concentration |
| B. | Plasma drug concentration/rate of urinary excretion |
| C. | 1/ Plasma drug concentration |
| D. | 1/rate of urinary excretion |
| Answer» B. Plasma drug concentration/rate of urinary excretion | |
| 494. |
Which route of drug administration shows 100% Bioavailability? |
| A. | Oral |
| B. | Intravenous |
| C. | Rectal |
| D. | Topical |
| Answer» C. Rectal | |
| 495. |
In equation X=Vd C, what does Vd denotes? |
| A. | Density |
| B. | Volume of blood |
| C. | Volume of body |
| D. | The volume of the body fluid in which the drug is getting dissolved |
| Answer» E. | |
| 496. |
The concentration of drug in plasma above which toxic effects are precipitated is known as |
| A. | Maximum safe concentration |
| B. | Minimum Effective Concentration |
| C. | Intensity of Action |
| D. | Duration of Action |
| Answer» B. Minimum Effective Concentration | |
| 497. |
What is the mean length of GIT? |
| A. | 350 cm |
| B. | 200cm |
| C. | 400cm |
| D. | 450cm |
| Answer» E. | |
| 498. |
For oral formulation, what should be the minimum aqueous solubility to avoid bioavailabilityproblems? |
| A. | 0.9% |
| B. | 1% |
| C. | 2% |
| D. | 0.11% |
| Answer» C. 2% | |
| 499. |
Who has higher fat content? |
| A. | Adults of age above 70 |
| B. | Adults of age more than 20 |
| C. | Infants and elders |
| D. | Children at puberty |
| Answer» D. Children at puberty | |
| 500. |
What is the equation of bioavailable fraction? |
| A. | 1/Bioavailable dose |
| B. | 1/Administered dose |
| C. | Bioavailable dose/Administered dose |
| D. | Administered dose/Bioavailable dose |
| Answer» D. Administered dose/Bioavailable dose | |