MCQOPTIONS
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MCQOPTIONS
This section includes 925 Mcqs, each offering curated multiple-choice questions to sharpen your GPAT knowledge and support exam preparation. Choose a topic below to get started.
| 401. |
USP Apparatus 5 is |
| A. | Flow-through- cell |
| B. | paddle over disk |
| C. | Cylinder |
| D. | Paddle |
| Answer» C. Cylinder | |
| 402. |
What is the name of the specialized cells that support the blood-brain barrier tissue? |
| A. | Astrocytes |
| B. | Dendrites |
| C. | Fat cells |
| D. | Endothelial cells |
| Answer» B. Dendrites | |
| 403. |
Below mentioned all factors increases plasma elimination half life except |
| A. | Higher protein binding |
| B. | Higher tissue binding |
| C. | Higher apparent Vd |
| D. | Higher ratio renal / hepatic clearance |
| Answer» E. | |
| 404. |
Which compounds are excreted through the lungs? |
| A. | Lipophilic |
| B. | Gaseous |
| C. | Liquid and hydrophilic |
| D. | Solid less than 100 Dalton |
| Answer» C. Liquid and hydrophilic | |
| 405. |
In cell membrane the hydrocarbon chains for hydrophilic phase and the polar heads formhydrophobic phase. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 406. |
IV route of drug administration does not involve………… |
| A. | distribution step |
| B. | absorption step |
| C. | biotransformation step |
| D. | All of the above |
| Answer» C. biotransformation step | |
| 407. |
Systemic clearance (Cl) is related with: |
| A. | only the concentration of substances in plasma |
| B. | only the elimination rate constant |
| C. | volume of distribution, half life and elimination rate constant |
| D. | bioavailability and half life |
| Answer» D. bioavailability and half life | |
| 408. |
Which process involves alteration in drug excretion? |
| A. | Increased fluid flow |
| B. | Changes in urinary pH |
| C. | Both |
| D. | None |
| Answer» D. None | |
| 409. |
The area under the serum concentration time curve of the drug represents: |
| A. | the biological half life of the drug |
| B. | the amount of drug in the original dosage form |
| C. | The amount of drug absorbed |
| D. | The amount of drug excreted in the urine |
| Answer» D. The amount of drug excreted in the urine | |
| 410. |
What is the most important characteristic of a drug to be absorbed after oral administration? |
| A. | Dissolved in HCL |
| B. | Dissolved in alkaline solution |
| C. | Can pass through the cell membrane |
| D. | Form aggregate and settle down |
| Answer» D. Form aggregate and settle down | |
| 411. |
A girl with age 21 has height 240cm, weight 55kg, serum creatinine of 0.8mg will have ______________ creatinine clearance. |
| A. | 80 ml/min |
| B. | 90 ml/min |
| C. | 96.25 ml/min |
| D. | 85 ml/min |
| Answer» D. 85 ml/min | |
| 412. |
What is the driving force of Pore Transport? |
| A. | Hydrostatic pressure |
| B. | Concertation Gradient |
| C. | Electrochemical gradient |
| D. | Charge equilibration |
| Answer» B. Concertation Gradient | |
| 413. |
Which process involve alteration of drug distribution |
| A. | Competitive binding |
| B. | Reduced plasma protein level |
| C. | Both |
| D. | None |
| Answer» D. None | |
| 414. |
Which one of these is a physicochemical property of Drug substance? |
| A. | Drug solubility |
| B. | Disintegration time |
| C. | Age of patient |
| D. | Dissolution time |
| Answer» B. Disintegration time | |
| 415. |
……….. is a mathematical concept which describes a space in the body which a drug appears tooccupy. |
| A. | Order of reaction |
| B. | Compartment |
| C. | Distribution |
| D. | Elimination |
| Answer» C. Distribution | |
| 416. |
The renal clearance of a drug bound to plasma protein is increased after displacement with anotherdrug. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 417. |
What is the consequence of diet high in fats? |
| A. | The patient can’t be given with acidic drugs |
| B. | The patient can’t be given with basic drugs |
| C. | The basic drugs will aggregate and become poisonous for him |
| D. | The high fatty acid level affect the binding of acidic drugs |
| Answer» E. | |
| 418. |
Tick the feature of the sublingual route: |
| A. | Pretty fast absorption |
| B. | A drug is exposed to gastric secretion |
| C. | A drug is exposed more prominent liver metabolism |
| D. | A drug can be administered in a variety of doses |
| Answer» B. A drug is exposed to gastric secretion | |
| 419. |
In vitro dissolution rate studies on drug product are useful in bioavailability evaluation if they are correlated with |
| A. | Disintegration rate |
| B. | In vivo studies in at least 3 species of animals |
| C. | Chemical stability of drugs |
| D. | In vivo studies in human |
| Answer» E. | |
| 420. |
Which of the following is not a pharmacokinetic parameters that describe the plasma level time curve? |
| A. | tmax |
| B. | cmax |
| C. | Area under Curve |
| D. | Minimum Effective Concentration |
| Answer» E. | |
| 421. |
Which is the major process of absorption for more than 90% of drugs? |
| A. | Facilitated diffusion |
| B. | Active transport |
| C. | Endocytosis |
| D. | Passive diffusion |
| Answer» E. | |
| 422. |
The gold coating on a USP Dissolution apparatus - I basket should be: |
| A. | Not more than 2.5 m in thickness |
| B. | Not more than 0.1 mm in thickness |
| C. | Not more than 0.025 m in thickness |
| D. | Not more than 0.22 mm in thickness |
| Answer» B. Not more than 0.1 mm in thickness | |
| 423. |
The entire length of the GI is lined by ___________ |
| A. | Blood vessels |
| B. | Nerves |
| C. | Mucopolysaccharides |
| D. | No lining direct contact with the cell |
| Answer» D. No lining direct contact with the cell | |
| 424. |
The drug concentration between MEC and MSC represents the…. |
| A. | Therapeutic Index |
| B. | Therapeutic range |
| C. | Therapeutic outcome |
| D. | Therapeutic ratio |
| Answer» C. Therapeutic outcome | |
| 425. |
Fick's law is used for study of |
| A. | Dissolution rate |
| B. | Disintegration rate |
| C. | Dissociation rate |
| D. | Diffusion rate |
| Answer» E. | |
| 426. |
Which sentence will define the Dissolution rate? |
| A. | Amount of solid substrate that goes into solution under constant time |
| B. | Amount of solid substrate that goes into solution under constant time under standard temperature |
| C. | Amount of solid substrate that goes into solution under constant time under standard temperature, pH, and pressure |
| D. | Amount of solid substrate that goes into solution under constant time under standard temperature, pH, solvent composition and constant surface area |
| Answer» E. | |
| 427. |
Why dopamine cannot be administered for the disease Parkinsonism? |
| A. | Don’t have a medicine |
| B. | It is not the medicine |
| C. | Cannot cross the blood-brain barrier |
| D. | Forms aggregate and thus cannot cross the BBB |
| Answer» D. Forms aggregate and thus cannot cross the BBB | |
| 428. |
This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = (140 – Age) W / 72 * Scr formula belong to? |
| A. | 1-6 years |
| B. | 1-20 years |
| C. | Males above 20 years |
| D. | Females above 20 years |
| Answer» D. Females above 20 years | |
| 429. |
How do you calculate the ideal body weight for a woman? |
| A. | 50 kg +- 1kg/2.5cm above or below 150 cm in height |
| B. | 45 kg +- 1kg/2.5cm above or below 150 cm in height |
| C. | 40 kg +- 1kg/2.5cm above or below 150 cm in height |
| D. | 35 kg +- 1kg/2.5cm above or below 150 cm in height |
| Answer» C. 40 kg +- 1kg/2.5cm above or below 150 cm in height | |
| 430. |
Which of the following drug cannot pass through the plasma membrane barrier? |
| A. | Drug size less than 50 Dalton |
| B. | Lipophilic drugs 50-600 Dalton |
| C. | Polar or ionized drugs of size greater than 50 Dalton |
| D. | Drug size more than 600 Dalton |
| Answer» E. | |
| 431. |
Blood Brain Barrier is maximum permeable to |
| A. | Na+ |
| B. | C02 |
| C. | Cl |
| D. | K+ |
| Answer» C. Cl | |
| 432. |
Noyes and Whitney equation is used to describe____________ |
| A. | Absorption |
| B. | Dissolution |
| C. | Distribution |
| D. | Disintegration |
| Answer» C. Distribution | |
| 433. |
Which of the following is used in molecular encapsulation of drugs for enhancing bioavailability? |
| A. | Highly water-soluble compound |
| B. | Cyclodextrin |
| C. | Inorganic clays like bentonite |
| D. | Creating metastable polymorphs |
| Answer» C. Inorganic clays like bentonite | |
| 434. |
A suspension shows zero-order kinetic with a rate constant 2mg/ml.month. The dose of suspension is 20mg/ml. The biological half life of the above dosage form is |
| A. | 5 months |
| B. | 1 month |
| C. | 3 months |
| D. | 2 months |
| Answer» B. 1 month | |
| 435. |
Biological barriers include all except: |
| A. | Renal tubules |
| B. | Cell membranes |
| C. | Capillary walls |
| D. | Placenta |
| Answer» B. Cell membranes | |
| 436. |
How can we increase the time of gastric emptying? |
| A. | By drinking a lot of water |
| B. | By taking a drug in empty stomach |
| C. | By taking the drug after food |
| D. | Cannot increase the time of gastric emptying at all |
| Answer» D. Cannot increase the time of gastric emptying at all | |
| 437. |
According to pH partition theory, a weak acidic drug will most likely be absorbed from the stomachbecause the drug which exists primarily in the…………. |
| A. | un-ionised, more lipid soluble form |
| B. | ionised, more water soluble form |
| C. | form of weak acid and more soluble in acid media |
| D. | ionic form of the drug which facilitates diffusion |
| Answer» B. ionised, more water soluble form | |
| 438. |
A hydrophilic medicinal agent has the following property: |
| A. | Low ability to penetrate through the cell membrane lipids |
| B. | Penetrate through membranes by means of endocytosis |
| C. | Easy permeation through the blood-brain barrier |
| D. | High reabsorption in renal tubules |
| Answer» B. Penetrate through membranes by means of endocytosis | |
| 439. |
Multiple dose study is better since we can understand the peak, valley, drug blood levels, etc. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 440. |
What is the principal barrier for the drugs on the topical application? |
| A. | The Dermis |
| B. | The subcutaneous fat tissue |
| C. | The stratum corneum |
| D. | The blood vessels below the skin |
| Answer» D. The blood vessels below the skin | |
| 441. |
Which model does not approve the existence of the stagnant layer in the solid-liquid interface? |
| A. | Interfacial barrier model |
| B. | Diffusion layer model |
| C. | Penetration or surface renewal theory |
| D. | Danckwert’s model |
| Answer» E. | |
| 442. |
The body water has 3 distinct compartments. Which one of these is not one of the compartments? |
| A. | Vascular fluid |
| B. | Intracellular fluid |
| C. | Extracellular fluid |
| D. | Between the tissue layers |
| Answer» E. | |
| 443. |
Constant rate infusion prevents………..in blood levels. |
| A. | fluctuations |
| B. | peak maximum |
| C. | valley minimum |
| D. | all of the above |
| Answer» E. | |
| 444. |
What will be the apparent volume of distribution of warfarin? |
| A. | The apparent volume of distribution is less than the true volume of distribution |
| B. | The apparent volume of distribution is more than the true volume of distribution |
| C. | The apparent volume of distribution is equal to the true volume of distribution |
| D. | Warfarin is not a medicine |
| Answer» B. The apparent volume of distribution is more than the true volume of distribution | |
| 445. |
What is therapeutic equivalence? |
| A. | Two or more drug products contain the same labeled chemical substance in the same amount |
| B. | Two or more drug products contain the same labeled chemical substance in different quantity |
| C. | Two or more drug products contain the same labeled chemical substance giving the same therapeutic effect |
| D. | Two or more drug products contain the same labeled chemical substance giving a different therapeutic effect |
| Answer» D. Two or more drug products contain the same labeled chemical substance giving a different therapeutic effect | |
| 446. |
The order of dissolution and absorption for different solid dosage forms is |
| A. | Stable > Amorphous > meta-stable |
| B. | Amorphous > meta-stable > stable |
| C. | Meta-stable > stable > Amorphous |
| D. | None of the above |
| Answer» C. Meta-stable > stable > Amorphous | |
| 447. |
Bioavailability differences among oral formulations of a drug are most likely to occur if the drug |
| A. | Is freely water soluble |
| B. | Is completely absorbed |
| C. | Is incompletely absorbed |
| D. | Undergoes little first-pass metabolism |
| Answer» D. Undergoes little first-pass metabolism | |
| 448. |
Who has more intracellular and extracellular water more in their body? |
| A. | Aged |
| B. | Adults Of age more than 20 |
| C. | Infants |
| D. | Children at puberty |
| Answer» D. Children at puberty | |
| 449. |
Nitrazepam a weak base, will be in which form in the stomach? |
| A. | Ionized form mostly |
| B. | Non-ionized form mostly |
| C. | Half ionized and half no ionized |
| D. | Will form aggregate |
| Answer» B. Non-ionized form mostly | |
| 450. |
The distribution of drugs into the central nervous system (brain) usually depends on: |
| A. | Aqueous diffusion |
| B. | Lipid diffusion |
| C. | Active transport |
| D. | Facilitated tr |
| Answer» B. Lipid diffusion | |