MCQOPTIONS
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MCQOPTIONS
This section includes 925 Mcqs, each offering curated multiple-choice questions to sharpen your GPAT knowledge and support exam preparation. Choose a topic below to get started.
| 351. |
Which of the following sentences will be the actual definition of folds of Kerckring? |
| A. | Folds of the intestinal mucosa |
| B. | Finger-like projections whose other name is villi |
| C. | Protruding surface from the villi |
| D. | Cilia over the surface of villi |
| Answer» B. Finger-like projections whose other name is villi | |
| 352. |
Protein binding of drugs helps to maintain ……………for absorption of drugs. |
| A. | non sink condition |
| B. | sink condition |
| C. | pKa |
| D. | none of the above |
| Answer» C. pKa | |
| 353. |
If drug have very small volume of distribution it is likely that the drug |
| A. | Has short biological half life |
| B. | Does not accumulate in various tissue and organ |
| C. | Not bioavailable |
| D. | will not be effective |
| Answer» C. Not bioavailable | |
| 354. |
Absorption of poorly soluble drug is |
| A. | diffusion rate limited |
| B. | dissolution rate limited |
| C. | both (a) & (b) |
| D. | none of the above |
| Answer» C. both (a) & (b) | |
| 355. |
Based on Henderson-Hasselbalch equation, at what pH value a weak acid would be 99.9% ionized? |
| A. | At pH equivalent to pKa - 3 |
| B. | At pH equivalent to pKa + 3 |
| C. | At pH equivalent to pKa – 1 |
| D. | At pH equivalent to pKa + 1 |
| Answer» C. At pH equivalent to pKa – 1 | |
| 356. |
The process of engulfing of particulate material is called |
| A. | Pinocytosis |
| B. | Phagocytosis |
| C. | Convective transport |
| D. | Facilitated diffusion |
| Answer» C. Convective transport | |
| 357. |
Two most common protein involved in plasma protein binding are |
| A. | Globulin and plasmin |
| B. | Albumin and globulin |
| C. | Fibrin and globulin |
| D. | Plasmin and fibrin |
| Answer» C. Fibrin and globulin | |
| 358. |
What is the perfusion rate? |
| A. | The total volume of blood |
| B. | The volume of blood that flows through the heart per unit time |
| C. | The volume of blood that flows per unit time per unit volume of tissue |
| D. | The volume of tissue that flows per unit time per unit area of a blood vessel |
| Answer» D. The volume of tissue that flows per unit time per unit area of a blood vessel | |
| 359. |
Larger the size of the counterion, greater the solubility. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 360. |
Which of the following is not the characteristic of the carrier mediated transport system? |
| A. | Energy dependent |
| B. | Reach equilibrium |
| C. | Metabolically inhibited |
| D. | Structurally specific and saturable |
| Answer» C. Metabolically inhibited | |
| 361. |
When the solvent in association with the drug is water, the solvate is known as |
| A. | anhydrate |
| B. | amorphous |
| C. | hydrate |
| D. | none of the above |
| Answer» D. none of the above | |
| 362. |
If the bioavailability of test formulation is 80-120% of the reference standard, it is considered to bebioequivalent. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 363. |
The formula to calculate half life (t1/2) is |
| A. | 0.693 *Vd / C1 |
| B. | 0.693 *Cl / Vd |
| C. | 0.693 / Cl * Vd |
| D. | 0.693 / Cl |
| Answer» B. 0.693 *Cl / Vd | |
| 364. |
This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = (140 – Age) W / 85 * Scr formula belong to? |
| A. | 1-6 years |
| B. | 1-20 years |
| C. | Males above 20 years |
| D. | Females above 20 years |
| Answer» E. | |
| 365. |
Which of the following is not a mechanism for pharmacokinetic analysis? |
| A. | Compartment analysis |
| B. | Non compartment analysis |
| C. | Physiologic modeling |
| D. | Human model |
| Answer» E. | |
| 366. |
Conjugation is: |
| A. | Process of drug reduction by special enzymes |
| B. | Process of drug oxidation by special oxidases |
| C. | Coupling of a drug with an endogenous substrate |
| D. | Solubilization in lipids |
| Answer» D. Solubilization in lipids | |
| 367. |
Which one of the following is not an advantage of sublingual or buccal administration? |
| A. | Rapid absorption and higher blood levels |
| B. | No first-pass hepatic metabolism |
| C. | No degradation of drugs |
| D. | Limited surface area |
| Answer» E. | |
| 368. |
To avoid bioavailability issues, the drug must have a minimum aqueous solubility of |
| A. | 150% |
| B. | 10% |
| C. | 100% |
| D. | 1% |
| Answer» E. | |
| 369. |
What will be the particle size after micronization of drugs? |
| A. | 1-10 micron |
| B. | 10-20 micron |
| C. | 20-30 micron |
| D. | 1-5 micron |
| Answer» B. 10-20 micron | |
| 370. |
In which of the following models the body is considered to be composed of several compartments? |
| A. | Compartment model |
| B. | Noncompartment model |
| C. | Physiologic model |
| D. | Human model |
| Answer» B. Noncompartment model | |
| 371. |
Which of the following drugs are responsible for retinopathy? |
| A. | Acidic drugs like imipramine |
| B. | Basic drugs like imipramine |
| C. | Halogenated hydrocarbons |
| D. | Chloroquinine |
| Answer» E. | |
| 372. |
Which cell make up the blood-brain barrier? |
| A. | Squamous epithelium cells |
| B. | Fat cells |
| C. | Red blood cell |
| D. | Endothelial cells |
| Answer» E. | |
| 373. |
When the active transport system become saturated, the rate process become |
| A. | Zero order |
| B. | Second order |
| C. | Pseudo first order |
| D. | Pseudo zero order |
| Answer» B. Second order | |
| 374. |
What is the relation between halogenated hydrocarbon and liver? |
| A. | Halogenated hydrocarbon is a drug for liver problems |
| B. | Halogenated hydrocarbon is nutrition for liver |
| C. | Halogenated hydrocarbon causes hepatotoxicity |
| D. | Halogenated hydrocarbon forms the bile juices in liver |
| Answer» D. Halogenated hydrocarbon forms the bile juices in liver | |
| 375. |
Which tissue has the greatest capacity to biotransform of drugs? |
| A. | Kidney |
| B. | Lung |
| C. | Liver |
| D. | Skin |
| Answer» D. Skin | |
| 376. |
Why emulsion dosage form for lipophilic drug proved better? |
| A. | Easy manufacturing |
| B. | The higher stability of the drug in emulsion form |
| C. | Presented a large surface area of oil to the GIT for the absorption of the drug |
| D. | Fast clearance from the plasma |
| Answer» D. Fast clearance from the plasma | |
| 377. |
Which of the given drugs bind to Α1 globulin? |
| A. | Steroidal drugs |
| B. | Vitamins A, D, E, K |
| C. | Ferrous ions |
| D. | Carotenoids |
| Answer» B. Vitamins A, D, E, K | |
| 378. |
Which of the following is used in solvent deposition method of enhancing bioavailability? |
| A. | Freeze drying |
| B. | Organic solvent |
| C. | Inorganic clays like bentonite |
| D. | Creating metastable polymorphs |
| Answer» C. Inorganic clays like bentonite | |
| 379. |
What is pharmaceutic equivalence? |
| A. | Two or more drug products contain the same labeled chemical substance in the same amount |
| B. | Two or more drug products are identical in quality, purity, uniformity, disintegration, dissolution |
| C. | Two or more drug products contain different labeled chemical substance giving the same therapeutic effect |
| D. | Two or more drug products contain the same labeled chemical substance giving a different therapeutic effect |
| Answer» C. Two or more drug products contain different labeled chemical substance giving the same therapeutic effect | |
| 380. |
The half life of a drug eliminated by first order elimination kinetics will be longer in individuals whohave an: |
| A. | increased volume of distribution or increased clearance |
| B. | increased volume of distribution or decreased clearance |
| C. | decreased volume of distribution or increased clearance |
| D. | decreased volume of distribution or decreased clearance |
| Answer» C. decreased volume of distribution or increased clearance | |
| 381. |
Bioavailability is expressed by formula |
| A. | AUC IV / AUC oral |
| B. | AUC ora1 X AUC IV |
| C. | AUC ora1 / AUC IV |
| D. | None of the above |
| Answer» B. AUC ora1 X AUC IV | |
| 382. |
Which one of these is not an example of a basic drug with pKa range 5-11? |
| A. | Cromolyn |
| B. | Imipramine |
| C. | Amitriptyline |
| D. | Chloroquine |
| Answer» B. Imipramine | |
| 383. |
Half life of zero-order process is proportional to of drug. |
| A. | initial concentration |
| B. | final concentration |
| C. | both (a) & (b) |
| D. | none of the above |
| Answer» B. final concentration | |
| 384. |
Which drugs get absorbed in the stomach mostly? |
| A. | Basic drugs |
| B. | Acidic Drugs |
| C. | Neutral drugs |
| D. | No drug gets absorbed in the stomach |
| Answer» C. Neutral drugs | |
| 385. |
………….is used to study gastric emptying. |
| A. | Barium sulphate |
| B. | Aluminum sulphate |
| C. | Calcium sulphate |
| D. | Aluminum hydroxide |
| Answer» B. Aluminum sulphate | |
| 386. |
Which one of them is not a common form of excipients of drug manufacturing? |
| A. | Diluents |
| B. | Binders |
| C. | Sweeteners |
| D. | Essential oils |
| Answer» E. | |
| 387. |
Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site? |
| A. | Competition between the drug and the binding site |
| B. | Competition between drugs and normal body constituents |
| C. | Allosteric changes in a protein molecule |
| D. | Inter subject variation |
| Answer» E. | |
| 388. |
Displacement is significant when, the displaced drug is more than protein bound. |
| A. | 50% |
| B. | 95% |
| C. | 10% |
| D. | 1% |
| Answer» C. 10% | |
| 389. |
This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = 0.48 H / Scr *[W/70]0.7 formula belong to? |
| A. | 1-6 years |
| B. | 1-20 years |
| C. | Males above 20 years |
| D. | Females above 20 years |
| Answer» C. Males above 20 years | |
| 390. |
Which drug causes brown yellow discoloration of infant’s teeth? |
| A. | Arsenicals |
| B. | Tetracycline |
| C. | Halogenated hydrocarbons |
| D. | Lipophilic drug |
| Answer» C. Halogenated hydrocarbons | |
| 391. |
When rate is independent of the reactant concentration, then it is called |
| A. | zero order reaction |
| B. | Pseudo zero order reaction |
| C. | First order reaction |
| D. | Second order reaction |
| Answer» B. Pseudo zero order reaction | |
| 392. |
The rate of drug transport across a cell membrane by lipid diffusion depends on all of the followingexcept |
| A. | Drug size (diffusion constant) |
| B. | Surface area of absorption |
| C. | Lipid partition coefficient |
| D. | Density of tr |
| Answer» B. Surface area of absorption | |
| 393. |
The ability of liver to excrete drug in bile is expressed by……… |
| A. | hepatic clearance |
| B. | biliary clearance |
| C. | non-renal clearance |
| D. | renal clearance |
| Answer» C. non-renal clearance | |
| 394. |
Which is the other name of “cell eating”? |
| A. | Transcytosis |
| B. | Phagocytosis |
| C. | Pinocytosis |
| D. | Endocytosis |
| Answer» C. Pinocytosis | |
| 395. |
Which of the following is not an approach for overcoming bioavailability problems? |
| A. | Pharmaceutic approach |
| B. | Pharmacokinetic approach |
| C. | Biologic approach |
| D. | Partition coefficient approach |
| Answer» E. | |
| 396. |
Which of the following factors for protein drug binding is a drug interaction factor? |
| A. | Competition between drugs for the binding site |
| B. | Age |
| C. | Physicochemical characteristics of a drug |
| D. | Physicochemical characteristics of the protein or binding agent |
| Answer» B. Age | |
| 397. |
The occurrence of food in the GI tract can affect the drug bioavailability from an oral drug product.The above give statement is? |
| A. | True |
| B. | False |
| C. | Both of the above |
| D. | None of the above |
| Answer» B. False | |
| 398. |
Bioavailability from IV route is……% |
| A. | 10 |
| B. | 100 |
| C. | 1000 |
| D. | 10000 |
| Answer» C. 1000 | |
| 399. |
Absorption of drugs can be categorized into 2 classes, physicochemical properties of drugs and Dosage form of the drug, on the basis of drug dissolution. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 400. |
Under compartment modeling, Wegner-Nelson-Method involves |
| A. | Determination of absorption rate constant (Ka) from %ARA Vs time curve |
| B. | Determination of elimination rate constant (Ka) from % ARA Vs time curve |
| C. | Determination of absorption rate constant (Ke) from %ARA •Vs Concentration curve |
| D. | Determination of plasma half life |
| Answer» B. Determination of elimination rate constant (Ka) from % ARA Vs time curve | |