Which of the given statements is incorrect about Clusters of orthologous groups?

• A. Using the protein from one of the organisms to search the proteome of the other for high-scoring matches should identify the ortholog as the highest- scoring match, or best hit
• B. When entire proteomes of the two organisms are available, orthologs may be identified
• C. a pair of orthologous genes in two organisms share so much sequence similarity that they may be assumed to have arisen from a common ancestor gene
• D. each of the orthologs belongs to a family composed of paralogous sequences but irrelevant or not related to each other