Explore topic-wise MCQs in Bioinformatics.

This section includes 12 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.

1.

Which of the following is untrue about Electrostatic Complementarity?

A. The electrostatic properties of biomolecules play an important role in determining interactions
B. The burial of charged residues at protein-protein/DNA interfaces is thought to be generally net destabilizing with the hydrophobic effect being the primary driving force
C. Charged groups involved in the biomolecular interface are often stabilized by other polar or oppositely charged groups on the interacting molecule
D. Charged groups involved in the biomolecular interface are often stabilized by similar polar or same charged groups on the interacting molecule
Answer» E.
Discussion
2.

Oligomers are often obligate complexes meaning that the free-energy cost of dissociation is high and they exist as oligomers under physiological conditions.

A. True
B. False
Answer» B. False
Discussion
3.

Which of the following is untrue about Hydrophobicity?

A. The hydrophobic effect plays a dominant role in the folding of proteins
B. Hydrophobic residues aggregate away from contact with water
C. Hydrophobic residues aggregate to form hydrophobic cores with more polar residues
D. Hydrophobic residues form the solvent accessible surface but restrict the solubility of the protein
Answer» E.
Discussion
4.

In Property-based measures, displaying physical properties on the molecular surface of molecules can help to guide molecular docking.

A. True
B. False
Answer» B. False
Discussion
5.

In Grid representation, the lowest score represents the best surface complementarity for a given translational scan.

A. True
B. False
Answer» C.
Discussion
6.

In Grid representation, in a translational scan the mobile molecule B moves through the grid representing the static molecule A and a signal describing shape complementarity, fc, is generated for each mapping. Mathematically the correlation function, fc, of fA and fB is given by ______ where N is the number of grid points along the cubic axes i, j, and k and α, β, and γ are the translational vectors of the mobile molecule B relative to the static one A.

A. fc = \(\sum_{i=1,j=1,k=1}^N\) (fA,i,j,k * fBi+αj+βk+ɣ)
B. fc = \(\sum_{i=0,j=0,k=0}^N\) (fA,i,j,k * fBi+αj+βk+ɣ)
C. fc = \(\sum_{i=1,j=1,k=1}^N\) (fA,0,0,0 * fBi+αj+βk+ɣ)
D. fc = \(\sum_{i=0,j=0,k=0}^N\) (f0,i,j,k * fBi+αj+βk+ɣ)
Answer» B. fc = \(\sum_{i=0,j=0,k=0}^N\) (fA,i,j,k * fBi+αj+βk+ɣ)
Discussion
7.

WHICH_OF_THE_FOLLOWING_IS_UNTRUE_ABOUT_HYDROPHOBICITY??$

A. The hydrophobic effect plays a dominant role in the folding of proteins
B. Hydrophobic residues aggregate away from contact with water
C. Hydrophobic residues aggregate to form hydrophobic cores with more polar residues
D. Hydrophobic residues form the solvent accessible surface but restrict the solubility of the protein
Answer» E.
Discussion
8.

In Property-based measures, displaying physical properties on the molecular surface of molecules can help to guide molecular docking?

A. True
B. False
Answer» B. False
Discussion
9.

Which of the following is untrue about Grid Representation?

A. To speed up the matching process the topology of the protein can be simplified from atomic level detail to a series of cubic elements
B. To speed up the matching process discretizing the 3-dimensional space using a grid is done
C. Discretizing allows very fast computer matching using search methods such as Fourier transform
D. Fourier transform is hardly used in computer matching
Answer» E.
Discussion
10.

The burial of surface area (or the maximization of surface contact) is an approximation of the effect of shape complementarity.

A. True
B. False
Answer» B. False
Discussion
11.

Which of the following is untrue about Shape Complementarity?

A. The complementarity between two proteins or a protein and ligand can be described by surface contact or overlap
B. The complementarity between two proteins or a protein and ligand can be described by the overall buried surface area of two molecules in contact
C. The complementarity between two proteins or a protein and ligand can be described by the number of adjacent surface points (atoms or residues)
D. The hydrophobic effect barely has impact on protein folding
Answer» E.
Discussion
12.

Which of the following is untrue about Amino acid conservation?

A. It has been known for some time that conservation of residues at the surface of a protein family is often related to function
B. Conservation of residues at the core of a protein family is often related to function
C. This may be an enzyme active-site or binding site
D. Unlike hydrophobicity or electrostatic potential, displaying residue conservation on the molecular surface has no physical or chemical basis
Answer» C. This may be an enzyme active-site or binding site
Discussion