Domains that are part of a multidomain protein are ______

nethier co-regulated nor colocalized

not co-regulated but colocalized

co-regulated and but not colocalized

An approach for predicting ______ to look for cases across a set of genomes where _____ are part of the same gene in one genome resulted in gene fusion method.

protein interactions, two orthologs

gene interactions, only three to four orthologs

gene interactions, two orthologs

protein interactions, two or more orthologs

protein interactions, two orthologs

Conservation of gene order due to operon structure is _______ so interactions of proteins specific to eukaryotes cannot be detected by method of Conservation of gene order.

not applicable to archea genomes

not applicable to prokaryote genomes

applicable to eukaryote genomes

not applicable to eukaryote genomes

Interactions between proteins can be predicted computationally by looking for sets of genes that occur as a _______

multiple genes in at least one genome

single gene in at least one genome

multiple genes in at least one genome

multiple genes in various genomes

15 + Mcqs in The Use of Gene Order & Phylogeny to Predict Protein Protein Interactions in Bioinformatics Page 1 McqOptions

1.	The most detailed experimental information about protein-protein interactions comes from three-dimensional structures.
A.	True
B.	False
Answer» B. False

Discussion

2.	Structural analyses on small sets of proteins have shown that the domains from a pair of families bind to each other with the same geometry in multi-domain proteins and in transient interactions.
A.	True
B.	False
Answer» B. False

Discussion

3.	In the phylogenetic profile method for predicting protein interaction, presence or absence of orthologous genes is scored across a variety of genomes.
A.	True
B.	False
Answer» B. False

Discussion

4.	In the assessment of methods to predict protein-protein interactions, one third of such pairs were found to physically interact, and an additional third to belong to the same metabolic pathway or functional process.
A.	True
B.	False
Answer» B. False

Discussion

5.	The phylogenetic profile method relies on detection of orthologs (or homologs, in a variation of the method) in a set of genomes.
A.	True
B.	False
Answer» B. False

Discussion

6.	Due to the requirement for co-regulation as well as colocalization, the method is mostly limited to certain classes of protein-protein interactions.
A.	True
B.	False
Answer» B. False

Discussion

7.	Domains that are part of a multidomain protein are ______
A.	nethier co-regulated nor colocalized
B.	not co-regulated but colocalized
C.	co-regulated and but not colocalized
D.	co-regulated and colocalized
Answer» E.

Discussion

8.	An approach for predicting ______ to look for cases across a set of genomes where _____ are part of the same gene in one genome resulted in gene fusion method.
A.	gene interactions, only three to four orthologs
B.	gene interactions, two orthologs
C.	protein interactions, two or more orthologs
D.	protein interactions, two orthologs
Answer» D. protein interactions, two orthologs

Discussion

9.	Conservation of gene order due to operon structure is _______ so interactions of proteins specific to eukaryotes cannot be detected by method of Conservation of gene order.
A.	not applicable to archea genomes
B.	not applicable to prokaryote genomes
C.	applicable to eukaryote genomes
D.	not applicable to eukaryote genomes
Answer» E.

Discussion

10.	In a quantitative assessment of this method (Conservation of gene order) using the genome of the parasitic organism Mycoplasma genitalium as a benchmark.
A.	True
B.	False
Answer» B. False

Discussion

11.	Members of a stable complex are often co-regulated and thus will be detected by the method of Conservation of gene order.
A.	True
B.	False
Answer» B. False

Discussion

12.	When comparing pairs of genes or sets of genes in different genomes for this purpose, it is not mandatory for the genes to be orthologs.
A.	True
B.	False
Answer» C.

Discussion

13.	Genes that are consistently part of the same operon across different, distantly related genomes are likely to be part of the same protein complex or functional process across all species.
A.	True
B.	False
Answer» B. False

Discussion

14.	Interactions between proteins can be predicted computationally by looking for sets of genes that occur as a _______
A.	single gene in at least one genome
B.	multiple genes in at least one genome
C.	multiple genes in various genomes
D.	single gene in various genomes
Answer» B. multiple genes in at least one genome

Discussion

15.	Experimentation is most desirable over computational methods by every means.
A.	True
B.	False
Answer» C.

Discussion

Explore topic-wise MCQs in Bioinformatics.

The most detailed experimental information about protein-protein interactions comes from three-dimensional structures.

Structural analyses on small sets of proteins have shown that the domains from a pair of families bind to each other with the same geometry in multi-domain proteins and in transient interactions.

In the phylogenetic profile method for predicting protein interaction, presence or absence of orthologous genes is scored across a variety of genomes.

In the assessment of methods to predict protein-protein interactions, one third of such pairs were found to physically interact, and an additional third to belong to the same metabolic pathway or functional process.

The phylogenetic profile method relies on detection of orthologs (or homologs, in a variation of the method) in a set of genomes.

Due to the requirement for co-regulation as well as colocalization, the method is mostly limited to certain classes of protein-protein interactions.

Domains that are part of a multidomain protein are ______

An approach for predicting __ to look for cases across a set of genomes where _ are part of the same gene in one genome resulted in gene fusion method.

Conservation of gene order due to operon structure is _______ so interactions of proteins specific to eukaryotes cannot be detected by method of Conservation of gene order.

In a quantitative assessment of this method (Conservation of gene order) using the genome of the parasitic organism Mycoplasma genitalium as a benchmark.

Members of a stable complex are often co-regulated and thus will be detected by the method of Conservation of gene order.

When comparing pairs of genes or sets of genes in different genomes for this purpose, it is not mandatory for the genes to be orthologs.

Genes that are consistently part of the same operon across different, distantly related genomes are likely to be part of the same protein complex or functional process across all species.

Interactions between proteins can be predicted computationally by looking for sets of genes that occur as a _______

Experimentation is most desirable over computational methods by every means.