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Maximum Likelihood Approach in Bioinformatics
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Experimentation is most desirable over computation..
1.
Experimentation is most desirable over computational methods by every means.
A.
True
B.
False
Answer» C.
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The most detailed experimental information about protein-protein interactions comes from three-dimensional structures.
Structural analyses on small sets of proteins have shown that the domains from a pair of families bind to each other with the same geometry in multi-domain proteins and in transient interactions.
In the phylogenetic profile method for predicting protein interaction, presence or absence of orthologous genes is scored across a variety of genomes.
In the assessment of methods to predict protein-protein interactions, one third of such pairs were found to physically interact, and an additional third to belong to the same metabolic pathway or functional process.
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Due to the requirement for co-regulation as well as colocalization, the method is mostly limited to certain classes of protein-protein interactions.
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