Explore topic-wise MCQs in Bioinformatics.

This section includes 6 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.

1.

Which of the following is untrue about Electrostatic Complementarity?

A. The electrostatic properties of biomolecules play an important role in determining interactions
B. The burial of charged residues at protein-protein/DNA interfaces is thought to be generally net destabilizing with the hydrophobic effect being the primary driving force
C. Charged groups involved in the biomolecular interface are often stabilized by other polar or oppositely charged groups on the interacting molecule
D. Charged groups involved in the biomolecular interface are often stabilized by similar polar or same charged groups on the interacting molecule
Answer» E.
Discussion
2.

Oligomers are often obligate complexes meaning that the free-energy cost of dissociation is high and they exist as oligomers under physiological conditions.

A. True
B. False
Answer» B. False
Discussion
3.

Which of the following is untrue about Hydrophobicity?

A. The hydrophobic effect plays a dominant role in the folding of proteins
B. Hydrophobic residues aggregate away from contact with water
C. Hydrophobic residues aggregate to form hydrophobic cores with more polar residues
D. Hydrophobic residues form the solvent accessible surface but restrict the solubility of the protein
Answer» E.
Discussion
4.

In Property-based measures, displaying physical properties on the molecular surface of molecules can help to guide molecular docking.

A. True
B. False
Answer» B. False
Discussion
5.

In Grid representation, the lowest score represents the best surface complementarity for a given translational scan.

A. True
B. False
Answer» C.
Discussion
6.

In Grid representation, in a translational scan the mobile molecule B moves through the grid representing the static molecule A and a signal describing shape complementarity, fc, is generated for each mapping. Mathematically the correlation function, fc, of fA and fB is given by ______ where N is the number of grid points along the cubic axes i, j, and k and , , and are the translational vectors of the mobile molecule B relative to the static one A.

A. f<sub>c</sub> = ( sum_{i=1,j=1,k=1}^N ) (f<sub>A,i,j,k</sub> * f<sub>Bi+ j+ k+ </sub>)
B. f<sub>c</sub> = ( sum_{i=0,j=0,k=0}^N ) (f<sub>A,i,j,k</sub> * f<sub>Bi+ j+ k+ </sub>)
C. f<sub>c</sub> = ( sum_{i=1,j=1,k=1}^N ) (f<sub>A,0,0,0</sub> * f<sub>Bi+ j+ k+ </sub>)
D. f<sub>c</sub> = ( sum_{i=0,j=0,k=0}^N ) (f<sub>0,i,j,k</sub> * f<sub>Bi+ j+ k+ </sub>)
Answer» B. f<sub>c</sub> = ( sum_{i=0,j=0,k=0}^N ) (f<sub>A,i,j,k</sub> * f<sub>Bi+ j+ k+ </sub>)
Discussion