Explore topic-wise MCQs in Bioinformatics.

This section includes 11 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.

1.

VAST is a web server that performs alignment using intramolecular approaches only.

A. True
B. False
Answer» C.
Discussion
2.

The root mean square deviation (RMSD), with the size dependency correction is?

A. \(\frac{RMSD}{-1.3 + 0.5 ln⁡(N+1)}\)
B. \(\frac{RMSD}{-1.3 + 0.5 ln⁡(N x N)}\)
C. \(\frac{RMSD}{-1.3 + 0.5 ln⁡(N-1)}\)
D. \(\frac{RMSD}{-1.3 + 0.5 ln⁡(N)}\)
Answer» E.
Discussion
3.

The root mean square deviation (RMSD), without the size dependency correction is?

A. \(\sum_{i=1}^N \frac{D_i^2}{N}\)
B. \(\sum_{i=1}^N \frac{D_i^2}{N + 1}\)
C. \(\sum_{i=1}^N \frac{D_i^2}{N x N}\)
D. \(\sum_{i=1}^N \frac{D_i^2}{N – 1}\)
Answer» B. \(\sum_{i=1}^N \frac{D_i^2}{N + 1}\)
Discussion
4.

VAST_IS_A_WEB_SERVER_THAT_PERFORMS_ALIGNMENT_USING_INTRAMOLECULAR_APPROACHES_ONLY?$

A. True
B. False
Answer» C.
Discussion
5.

Which of the following is incorrect about SSAP?

A. It is a web server that uses an intramolecular distance–based method
B. Matrices are built based on the Cβ distances of all residue pairs
C. Dynamic programming approach is not used here
D. Dynamic programming approach is used
Answer» D. Dynamic programming approach is used
Discussion
6.

Which of the following is incorrect about Multiple Structure Alignment?

A. The alignment strategy is different than the Clustal sequence alignment using a progressive approach
B. All structures are first compared in a pairwise fashion
C. A distance matrix is developed based on structure similarity scores such as RMSD
D. The aligned structures create a median structure that allows other structures to be progressively added for comparison based on the hierarchy described in the guide tree
Answer» B. All structures are first compared in a pairwise fashion
Discussion
7.

Which of the following is incorrect about the intramolecular approach?

A. The method works by generating a distance matrix between residues of the same protein
B. It generates a string between residues of the same protein
C. In comparing two protein structures, the distance matrices from the two structures are moved relative to each other to achieve maximum overlaps
D. By overlaying two distance matrices, similar intramolecular distance patterns representing similar structure folding regions can be identified
Answer» C. In comparing two protein structures, the distance matrices from the two structures are moved relative to each other to achieve maximum overlaps
Discussion
8.

The intramolecular approach does not depend on sequence similarity between the proteins to be compared.

A. True
B. False
Answer» B. False
Discussion
9.

Which of the following is incorrect about intermolecular approach?

A. This procedure starts with identifying equivalent residues or atoms
B. After residue–residue correspondence is established, one of the structures is moved laterally and vertically toward the other structure to allow the two structures to be in the same location
C. The structures are rotated relative to each other around the three-dimensional axes
D. The rotation doesn’t depend on the intermolecular distance
Answer» E.
Discussion
10.

The intermolecular approach is normally applied to relatively _____ structures.

A. distinctive
B. dissimilar
C. similar
D. different
Answer» D. different
Discussion
11.

Which of the following is incorrect about protein structure comparison?

A. The comparative approach is important in finding remote protein homologs
B. Protein structures have a much higher degree of conservation than the sequences
C. Protein structures have a much lesser degree of conservation than the sequences
D. Proteins can share common structures even without sequence similarity
Answer» D. Proteins can share common structures even without sequence similarity
Discussion