MCQOPTIONS
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MCQOPTIONS
This section includes 14 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
These limitations of the Zuker method and other methods have been largely overcome by using an algorithm originally described by Waterman and Byers (1985) for finding sequence alignments within a certain range of the optimal one by modifications of the trace-back procedure used in dynamic programming. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 2. |
A limitation of the Zuker method and other methods (Nakaya et al. 1995) for computing suboptimal RNA structures is that they do not compute all the structures within a given energy range of the minimum free-energy structure. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 3. |
Three scores, Pnum (i), Hnum (i,j), and Ssum, have been derived to assist with a determination of the reliability of a secondary structure prediction for a particular base i or a base pair i,j. Which of the following is not a correct regarding Ssum? |
| A. | is also called as ss-count |
| B. | is the number of foldings in which base i is single-stranded divided by m, the number of folding |
| C. | is the number of foldings in which base i is single-stranded multiplied by m, the number of folding |
| D. | gives the probability that base i is single-stranded |
| Answer» D. gives the probability that base i is single-stranded | |
| 4. |
Three scores, Pnum (i), Hnum (i,j), and Ssum, have been derived to assist with a determination of the reliability of a secondary structure prediction for a particular base i or a base pair i,j. Which of the following is not a correct regarding Hnum? |
| A. | is the sum of Pnum(i) and Pnum(j) -1 |
| B. | is the sum of Pnum(i) and Pnum(j) + 1 |
| C. | is the total number of dots in the ith row and jth column |
| D. | represents the total number of base pairs with the ith or jth base in the predicted structures |
| Answer» C. is the total number of dots in the ith row and jth column | |
| 5. |
Three scores, Pnum (i), Hnum (i,j), and Ssum, have been derived to assist with a determination of the reliability of a secondary structure prediction for a particular base i or a base pair i,j. Which of the following is not a correct regarding Pnum? |
| A. | is the total number of energy dots regardless of color in the i th row and i th column of the energy dot plot |
| B. | is the total number of energy dots considering the color in the ith row and ith column of the energy dot plot |
| C. | represents in an unfiltered dot plot |
| D. | represents the number of base pairs |
| Answer» C. represents in an unfiltered dot plot | |
| 6. |
In the programs related to FOLD, All complementary base pairs can be sampled in a fashion to determine which are present in a suboptimal structure. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 7. |
In the programs related to FOLD, the second region, the ________ region, is used to calculate the energy of the ________ structure. |
| A. | included, most likely |
| B. | included, best |
| C. | excluded, least likely |
| D. | excluded, best |
| Answer» E. | |
| 8. |
A_LIMITATION_OF_THE_ZUKER_METHOD_AND_OTHER_METHODS_(NAKAYA_ET_AL._1995)_FOR_COMPUTING_SUBOPTIMAL_RNA_STRUCTURES_IS_THAT_THEY_DO_NOT_COMPUTE_ALL_THE_STRUCTURES_WITHIN_A_GIVEN_ENERGY_RANGE_OF_THE_MINIMUM_FREE-ENERGY_STRUCTURE.?$ |
| A. | True |
| B. | False |
| Answer» B. False | |
| 9. |
These_limitations_of_the_Zuker_method_and_other_methods_have_been_largely_overcome_by_using_an_algorithm_originally_described_by_Waterman_and_Byers_(1985)_for_finding_sequence_alignments_within_a_certain_range_of_the_optimal_one_by_modifications_of_the_trace-back_procedure_used_in_dynamic_programming.$ |
| A. | True |
| B. | False |
| Answer» B. False | |
| 10. |
Three scores, Pnum (i), Hnum (i,j), and Ssum, have been derived to assist with a determination of the reliability of a secondary structure prediction for a particular base i or a base pair i,j. |
| A. | |
| B. | |
| Answer» C. | |
| 11. |
The program may be instructed to find structures within a certain percentage of the minimum free energy. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 12. |
In the programs related to FOLD, the second region, the ______ region, is used to calculate the energy of the ____ structure. |
| A. | included, most likely |
| B. | included, best |
| C. | excluded, least likely |
| D. | excluded, best |
| Answer» E. | |
| 13. |
To find suboptimal structures, the dynamic programming method was modified. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 14. |
Originally, the FOLD program of _____ predicted _____ having the minimum free energy. |
| A. | M. Zuker, two structures |
| B. | M. Wunsch, two structures |
| C. | M. Zuker, only one |
| D. | M. Wunsch, only one |
| Answer» D. M. Wunsch, only one | |