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MCQOPTIONS
This section includes 2539 Mcqs, each offering curated multiple-choice questions to sharpen your Current Affairs knowledge and support exam preparation. Choose a topic below to get started.
| 601. |
Which enzyme is of the utmost importance for the 2nd step in the formation ofGlucuronide? |
| A. | Esterase |
| B. | Amidases |
| C. | Transferase |
| D. | UDP-glucuronyl tr |
| Answer» B. Amidases | |
| 602. |
ω1 – oxidation of Valproic acid results in |
| A. | 2-hydroxy valproic acid |
| B. | 3-hydroxy valproic acid |
| C. | 4-hydroxy valproic acid |
| D. | 5-hydroxy valproic acid |
| Answer» D. 5-hydroxy valproic acid | |
| 603. |
Phase 1 reactions are also known as a synthetic reaction. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 604. |
Chelating agent Dimercaprol is used in the treatment of |
| A. | Lead poisoning |
| B. | Vanadium poisoning |
| C. | Arsenic poisoning |
| D. | All of above |
| Answer» D. All of above | |
| 605. |
Oxidation of Hexobarbital results in |
| A. | 2-hydroxy Hexobarbital |
| B. | 3-hydroxy Hexobarbital |
| C. | 4-hydroxy Hexobarbital |
| D. | 2,3-Dihydroxy Hexobarbital |
| Answer» C. 4-hydroxy Hexobarbital | |
| 606. |
First hormone epinephrine was synthesized in Year |
| A. | 1903 |
| B. | 1904 |
| C. | 1909 |
| D. | 1889 |
| Answer» C. 1909 | |
| 607. |
Which of the following is an antiarrhythmic drug that is a calcium channel blocker? |
| A. | Lidocaine |
| B. | Nitroglycerin |
| C. | Nifedipine |
| D. | Codeine |
| Answer» D. Codeine | |
| 608. |
In comparison with children and young adults, elderly adults tend to have a reducedcapacity to metabolize drugs. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 609. |
The most important physicochemical properties affecting drug action a) Partition coefficient b) Solubility c) Acid base properties d) Chemical bonding e) Chelation f) Surface activity |
| A. | All of the above |
| B. | A and B both |
| C. | D and E both |
| D. | C and F both |
| Answer» B. A and B both | |
| 610. |
Which type of hydrogen bonding present when hydrogen bonding occurs between molecules? |
| A. | Intramolecular |
| B. | Intermolecular |
| C. | A & B both |
| D. | None of them |
| Answer» C. A & B both | |
| 611. |
Dissolution & pka helps in drug |
| A. | ionization & solubility |
| B. | dissociation & transportation |
| C. | Dissociation & solubility |
| D. | None of these |
| Answer» D. None of these | |
| 612. |
By Glycine conjugation Benzoic acid results in |
| A. | Salicylic acid |
| B. | Oxalic acid |
| C. | Hippuric acid |
| D. | Carbamic acid |
| Answer» D. Carbamic acid | |
| 613. |
Which of the following drugs has self -induction to stimulate their own metabolism? |
| A. | Cortisol |
| B. | Pentobarbital |
| C. | Meprobamate |
| D. | Contraceptives |
| Answer» D. Contraceptives | |
| 614. |
Maternal drug metabolizing ability increases in the later stage of pregnancy. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 615. |
85% of drugs are ionizied in which pH- |
| A. | 2-5 |
| B. | 7-12 |
| C. | 1.5-8 |
| D. | Neutral |
| Answer» D. Neutral | |
| 616. |
The overall rate of biotransformation is higher in neonates and infants than in adults. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 617. |
A drug like phenytoin & barbiturate when pka is larger than 7 is |
| A. | Ionised at all pH |
| B. | unionised at pH |
| C. | Ionised at pH 8 |
| D. | Unionised at pH 6 |
| Answer» E. | |
| 618. |
Enantiomer has a higher affinity to receptor are called |
| A. | Eudismic |
| B. | Diastomer |
| C. | Eutomer |
| D. | None of these |
| Answer» B. Diastomer | |
| 619. |
Which of the following groups is least susceptible to cytochrome P450 enzymes? |
| A. | Terminal methyl groups |
| B. | Epoxide group |
| C. | Benzylic carbon atoms |
| D. | Quaternary carbon atoms |
| Answer» E. | |
| 620. |
Which of the following statements best describes pharmacodynamics? |
| A. | The study of how drugs reach their target in the body and how the levels of a drug in the blood are affected by absorption, distribution, metabolism and excretion. |
| B. | The study of how drugs can be designed using molecular modelling based on a drug's pharmacophore. |
| C. | The study of how a drug interacts with its target binding site at the molecular level. |
| D. | The study of which functional groups are important in binding a drug to its target binding site and the identification of a pharmacophore. |
| Answer» D. The study of which functional groups are important in binding a drug to its target binding site and the identification of a pharmacophore. | |
| 621. |
For dissolution of solute in solvent which condition is necessary?1. Solute-solvent interaction should be less than solute-solute and solvent-solvent interaction2. Solute-solvent interaction should equal solute-solute and solvent-solvent interaction3. Solute-solvent interaction should exceed solute-solute and solvent-solvent interaction |
| A. | 1 & 2 |
| B. | 2 & 3 |
| C. | 1 & 3 |
| D. | 1, 2 & 3 |
| Answer» C. 1 & 3 | |
| 622. |
What does the hydrolysis of Aspirin yield us with? |
| A. | Salicylic acid only |
| B. | Salicylic acid and CH3COOH |
| C. | CH3COOH |
| D. | Succinic acid |
| Answer» C. CH3COOH | |
| 623. |
In Lead and vanadium poisoning, which chelating agent is used as an antidote? |
| A. | Disodium EDTA |
| B. | Haemoglobin |
| C. | Cyanocobalamine |
| D. | Dimercaprol |
| Answer» B. Haemoglobin | |
| 624. |
What is the site of first-pass metabolism before molecules reach systemic circulation? |
| A. | Kidney |
| B. | Throat |
| C. | Liver |
| D. | Intestine |
| Answer» E. | |
| 625. |
What is the name of the process where the enzyme amount is decreases due to a decrease in enzyme synthesis? |
| A. | Altered physiology |
| B. | Repression |
| C. | Non-competitive inhibition |
| D. | Competitive inhibition |
| Answer» C. Non-competitive inhibition | |
| 626. |
Most weakly basic drugs (pKa > 8) are absorbed from |
| A. | Stomach |
| B. | Intestine |
| C. | Stomach and Intestine |
| D. | They Can’t be absorbed |
| Answer» C. Stomach and Intestine | |
| 627. |
The main goals of pre-clinical studies |
| A. | To determine the safe dose for first-in-man study |
| B. | To assess a product's safety profile |
| C. | A and B both |
| D. | None |
| Answer» D. None | |
| 628. |
Gentamicin, streptokinase can be given |
| A. | Orally |
| B. | Parentrally |
| C. | Both of above |
| D. | None of above |
| Answer» C. Both of above | |
| 629. |
The most abundant plasma protein is |
| A. | Albumin (HAS – Human serum albumin) |
| B. | Glycoprotein |
| C. | Lipoprotein |
| D. | Globulin |
| Answer» B. Glycoprotein | |
| 630. |
Which age group metabolizes drugs faster than the adults? |
| A. | Between 1-12 year |
| B. | Between 1-15 year |
| C. | Between 6-12 year |
| D. | Between 12-18 year |
| Answer» B. Between 1-15 year | |
| 631. |
Given reaction is the example of ________ |
| A. | Oxidation |
| B. | Reduction |
| C. | Hydrolysis |
| D. | Conjugation |
| Answer» D. Conjugation | |
| 632. |
Most weakly acidic drugs (pKa < 2) are absorbed from |
| A. | Stomach |
| B. | Intestine |
| C. | Stomach and Intestine |
| D. | They Can’t be absorbed |
| Answer» B. Intestine | |
| 633. |
What is enzyme induction? |
| A. | The phenomenon of increased drug metabolizing ability of enzymes by drugs and chemicals |
| B. | The phenomenon of increasing drug bioavailability drugs and chemicals |
| C. | The phenomenon of increasing drug distribution drugs and chemicals |
| D. | The phenomenon of increasing drug concentration for a particular tissue by drugs and chemicals |
| Answer» B. The phenomenon of increasing drug bioavailability drugs and chemicals | |
| 634. |
Absorption of neutral drugs (pKa 6- 8) is independent of pH. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 635. |
Dimercaprol is a chelating agent used in the treatment of |
| A. | Arsenic poisoning |
| B. | Lead poisoning |
| C. | Iron poisoning |
| D. | Vanadium poisoning |
| Answer» B. Lead poisoning | |
| 636. |
Oxidation of olefin results in |
| A. | Aldehyde |
| B. | Ketone |
| C. | Diol |
| D. | Carboxylic acid |
| Answer» D. Carboxylic acid | |
| 637. |
Differences observed in metabolism of drug among different races is known as |
| A. | Pharmacogenetics |
| B. | Ethnic variations |
| C. | Discontinues variation |
| D. | Polygenic control |
| Answer» C. Discontinues variation | |
| 638. |
Which of the following is not an example of a drug undergoing acetylation reaction? |
| A. | Hydrazine |
| B. | Salicylic acids |
| C. | Sulphonamides |
| D. | Histamines |
| Answer» C. Sulphonamides | |
| 639. |
Which of the following is not a characteristic of the moieties that are transferred to the substrate in phase II reactions? |
| A. | Simple endogenous molecules are transferred |
| B. | Large molecular sized groups are attached |
| C. | Strong polar groups are attached |
| D. | Strong nonpolar groups are attached |
| Answer» E. | |
| 640. |
IND stands for |
| A. | Improved new drug |
| B. | Investigational new drug |
| C. | International new drug |
| D. | International novel drug |
| Answer» C. International new drug | |
| 641. |
Angel of H-bond |
| A. | 1.3 – 1.8° |
| B. | 13-18° |
| C. | 130 – 180 ° |
| D. | 1300 – 1800 ° |
| Answer» D. 1300 – 1800 ° | |
| 642. |
Where is Protonsil converted to Sulfanilamide? |
| A. | Liver |
| B. | Gut |
| C. | Kidney |
| D. | Colon |
| Answer» C. Kidney | |
| 643. |
The non-polar compound dispersed |
| A. | By forming hydrogen bonding |
| B. | By interacting with lipid |
| C. | By forming drug receptor complex |
| D. | by forming hydrophilic bond |
| Answer» C. By forming drug receptor complex | |
| 644. |
Desulphuration of given drug results in _______ |
| A. | Phenobarbitone |
| B. | Paroxon |
| C. | Sulphanilamide |
| D. | PABA |
| Answer» B. Paroxon | |
| 645. |
Precision Medicine is an emerging approach depending on |
| A. | Genomic study of individual |
| B. | Diagnostic process of individual |
| C. | Diseases conditions |
| D. | None of above |
| Answer» B. Diagnostic process of individual | |
| 646. |
What is the inactive form of Codeine? |
| A. | Codene |
| B. | Codane |
| C. | Morphine |
| D. | Poppy |
| Answer» D. Poppy | |
| 647. |
Plasma proteins bound with drugs by formation of |
| A. | Hydrogen bonding |
| B. | Hydrophobc bonding |
| C. | Vander-waals force |
| D. | All |
| Answer» E. | |
| 648. |
Which of the following is not an optically isomer |
| A. | Enantiomers |
| B. | Epimers |
| C. | Disasters |
| D. | Meso |
| Answer» B. Epimers | |
| 649. |
pka is a parameter which indicates the |
| A. | Strength of drug as acid base reaction in water |
| B. | Aqueous phase in phosphate buffer |
| C. | Hydrophilic and lyphophilic character |
| D. | All of the above |
| Answer» E. | |
| 650. |
The phase I reactions are detoxification pathways. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |