MCQOPTIONS
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MCQOPTIONS
This section includes 2539 Mcqs, each offering curated multiple-choice questions to sharpen your Current Affairs knowledge and support exam preparation. Choose a topic below to get started.
| 551. |
Solubility of a drug in polar solvents and Non-polar solvents depends upon |
| A. | Chemical structure |
| B. | Particle size |
| C. | Crystal form |
| D. | All of above |
| Answer» E. | |
| 552. |
Intermediate of aromatic hydroxylation is |
| A. | Arene |
| B. | Epoxide |
| C. | Aldehyde |
| D. | Ketone |
| Answer» C. Aldehyde | |
| 553. |
What is the active form of salicylic acid? |
| A. | Sialic acid |
| B. | Salic acid |
| C. | Salicylic acid |
| D. | Salicycle acid |
| Answer» D. Salicycle acid | |
| 554. |
In QSAR, study of medicinal chemistry Q stands for |
| A. | Qualitative |
| B. | Quantitative |
| C. | Both |
| D. | Quantam |
| Answer» C. Both | |
| 555. |
What is the name of the process where structurally different compounds interact with the enzyme and prevent the metabolism of the drug? |
| A. | Altered physiology |
| B. | Repression |
| C. | Non-competitive inhibition |
| D. | Competitive inhibition |
| Answer» D. Competitive inhibition | |
| 556. |
Which age group is known as the neonates? |
| A. | Up to 2 months |
| B. | Up to 2 years |
| C. | Up to 6 months |
| D. | Up to 1 year |
| Answer» B. Up to 2 years | |
| 557. |
What is the name of the process where due to nutritional deficiency an enzyme content isdecreased? |
| A. | Altered physiology |
| B. | Repression |
| C. | Non-competitive inhibition |
| D. | Competitive inhibition |
| Answer» B. Repression | |
| 558. |
p-nitrophenol contains |
| A. | Intramolecular H-bond |
| B. | Intermolecular H-bond |
| C. | Both of above |
| D. | None of above |
| Answer» C. Both of above | |
| 559. |
The enzymes are divided into two categories, these are _______ and ______ |
| A. | Acidic drug metabolizing and basic drug metabolizing |
| B. | Present in the liver and not present in the liver |
| C. | Microsomal and non-microsomal |
| D. | There is no such division |
| Answer» D. There is no such division | |
| 560. |
Bioisosteres have |
| A. | Same physical properties |
| B. | Same chemical properties |
| C. | Similar biological properties |
| D. | All of above |
| Answer» E. | |
| 561. |
Who is founder of modem medicine? |
| A. | Hippocartes |
| B. | Clark |
| C. | Charak |
| D. | Henry's |
| Answer» B. Clark | |
| 562. |
What is polygenic control of drugs? |
| A. | Drug controlling seen in an individual |
| B. | Drug controlling seen in twins |
| C. | Drug controlling seen in between different species |
| D. | Drug controlling seen in a particular population |
| Answer» C. Drug controlling seen in between different species | |
| 563. |
Distance between H-bond is |
| A. | 2.3- 5.2 A° |
| B. | 1.2 – 2.5 A° |
| C. | 2.5 – 3.2 A° |
| D. | 3.2 – 8.5 A° |
| Answer» D. 3.2 – 8.5 A° | |
| 564. |
Which one of the following is reactive and a known carcinogenic? |
| A. | Cytochrome P-450 |
| B. | Catechol |
| C. | Glutathione |
| D. | Arene oxide |
| Answer» E. | |
| 565. |
What cytochrome P450 isozyme is most abundantly expressed in the human liver andintestines? |
| A. | CYP1A1 |
| B. | CYP3A4 |
| C. | CYP2C9 |
| D. | CYP2D6 |
| Answer» C. CYP2C9 | |
| 566. |
Oxadiazole ring contains |
| A. | 1 Nitrogen /Oxygen |
| B. | 2 Oxygen/ Nitrogen |
| C. | 2 Nitrogen/Sulphur |
| D. | 2 Nitrogen/Oxygen |
| Answer» E. | |
| 567. |
Aspirin is introduced by_________in 1889 |
| A. | Dreser's |
| B. | Emil Fischer and Mering |
| C. | Barger and Dale |
| D. | None of above |
| Answer» B. Emil Fischer and Mering | |
| 568. |
Which of the following statements best describes pharmacokinetics? |
| A. | The study of how drugs reach their target in the body and how the levels of a drug in the blood are affected by various factors. |
| B. | The study of how drugs can be designed using molecular modelling based on a drug's pharmacophore. |
| C. | The study of how a drug interacts with its target binding site at the molecular level. |
| D. | The study of which functional groups are important in binding a drug to its target binding site and the identification of a pharmacophore. |
| Answer» B. The study of how drugs can be designed using molecular modelling based on a drug's pharmacophore. | |
| 569. |
Phase IV trial is also known |
| A. | Base of clinical trial |
| B. | Multiple ascending dose era |
| C. | Post marketing Surveillance |
| D. | Pre-clinical trial |
| Answer» D. Pre-clinical trial | |
| 570. |
The hetroaromatic redical is called |
| A. | Anthryl |
| B. | Naphthyl |
| C. | Phenanthryl |
| D. | Dibenzyl |
| Answer» C. Phenanthryl | |
| 571. |
The process of bringing a new pharmaceutical drug to the market once the lead compound has been identified through the process of drug discovery. (From Lead to NDA) is known as |
| A. | Drug discovery |
| B. | Drug development |
| C. | Both of above |
| D. | None of above |
| Answer» C. Both of above | |
| 572. |
Diazepam gets metabolised into Hydroxydiazepam is example of |
| A. | Oxidation at allylic carbon atom |
| B. | Oxidation at the carbon alpha to carbonyl and imino group |
| C. | Oxidation at benzylic carbon atom |
| D. | Aromatic and Side chain Hydroxylation |
| Answer» C. Oxidation at benzylic carbon atom | |
| 573. |
Which enzyme is important in the Phase II reactions? |
| A. | Esterase |
| B. | Amidases |
| C. | Transferase |
| D. | Aldo-keto-reductases |
| Answer» D. Aldo-keto-reductases | |
| 574. |
A drug where pka is 7 & unionised at all pH it is |
| A. | Weak acidic |
| B. | Very weak acidic |
| C. | Weak basic |
| D. | Very weak basic |
| Answer» C. Weak basic | |
| 575. |
Identification of a new chemical entity as a potential therapeutic agent (From Hit to Lead)is known as |
| A. | Drug discovery |
| B. | Drug development |
| C. | Both of above |
| D. | None of above |
| Answer» B. Drug development | |
| 576. |
The most significant protein involved in binding with a drug is |
| A. | Albumin |
| B. | Glycoprotein |
| C. | Lipoprotein |
| D. | Globulin |
| Answer» B. Glycoprotein | |
| 577. |
What drug should not be given to a patient that is a poor CYP2D6 metabolizer? |
| A. | Codeine |
| B. | Lidocaine |
| C. | Nifedipine |
| D. | Nitroglycerin |
| Answer» B. Lidocaine | |
| 578. |
Name of this aromatic ring is |
| A. | Diphenylmethyl ethane |
| B. | 2-ethyl-1-methyl naphthalene |
| C. | 1-ethyl-2-methyl naphthalene |
| D. | 1-ethyl-1-methyl naphthalene |
| Answer» D. 1-ethyl-1-methyl naphthalene | |
| 579. |
Given reaction is the example of_________ |
| A. | Oxidation of Alicyclic carbon |
| B. | Oxidation of Aliphatic carbon |
| C. | Oxidation of Benzylic carbon |
| D. | Oxidation of Allylic carbon |
| Answer» B. Oxidation of Aliphatic carbon | |
| 580. |
Which form of barbituric acid has CNS activity? |
| A. | 1 |
| B. | 2 |
| C. | 3 |
| D. | All |
| Answer» D. All | |
| 581. |
Which of the following is not a common N containing functional groups which undergoreduction reactions? |
| A. | Nitro compounds |
| B. | Azo compounds |
| C. | N-oxide compounds |
| D. | Nitrite compounds |
| Answer» E. | |
| 582. |
Bioisoterism is the process of |
| A. | Replacement similar group |
| B. | Replacement similar valence group |
| C. | Replacement similar mass no. group |
| D. | Addition of group having different mass no. |
| Answer» C. Replacement similar mass no. group | |
| 583. |
Phenobarbitone is water insoluble but its which salt is water soluble? |
| A. | Sodium |
| B. | Hydrochloride |
| C. | Salicylate |
| D. | Palmitate |
| Answer» B. Hydrochloride | |
| 584. |
Fat-free diet depresses cytochrome P-450 level. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 585. |
What plays a major role in extra-hepatic metabolism and contains CYP3A4 isozyme andP-glycoprotein? |
| A. | Kidney |
| B. | Throat |
| C. | Liver |
| D. | Intestine |
| Answer» D. Intestine | |
| 586. |
Functional groups of same valance and ring equivalents are known as |
| A. | Classical Bioisosteres |
| B. | Non- Classical Bioisosteres |
| C. | Enantiomer |
| D. | Geometric isomer |
| Answer» B. Non- Classical Bioisosteres | |
| 587. |
The drug biotransformation is a detoxification process. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 588. |
Which of the following is not a bivalent? |
| A. | CO |
| B. | CS |
| C. | CC |
| D. | SH |
| Answer» E. | |
| 589. |
How many people will be selected for phase I trial? |
| A. | The whole market will be under surveillance |
| B. | 300-3000 people |
| C. | 20-300 people |
| D. | 20-50 people |
| Answer» E. | |
| 590. |
Which of the following is the correct decreasing order of drug metabolism? |
| A. | Liver > lungs > kidneys > intestine > placenta > skin > adrenals |
| B. | Liver > lungs > kidneys > intestine > adrenals > placenta > skin |
| C. | Liver > kidneys > lungs > intestine > placenta > adrenals > skin |
| D. | Liver > lungs > intestine > kidneys > placenta > adrenals > skin |
| Answer» B. Liver > lungs > kidneys > intestine > adrenals > placenta > skin | |
| 591. |
Carbon atom adjacent to olefinic double bond is known as |
| A. | Alicyclic carbon |
| B. | Aliphatic carbon |
| C. | Benzylic carbon |
| D. | Allylic carbon |
| Answer» E. | |
| 592. |
How many main families of GPCRs are there? |
| A. | 5 |
| B. | 6 |
| C. | 7 |
| D. | 4 |
| Answer» C. 7 | |
| 593. |
NDA is |
| A. | New Drug Application |
| B. | New Drug approval |
| C. | Noval Drug Admistration |
| D. | New Drug agenda |
| Answer» B. New Drug approval | |
| 594. |
Absorption of Tetracycline is reduced in the presence of milk because of |
| A. | Hydrogen bonding |
| B. | Protein binding |
| C. | Ionization |
| D. | Chelation |
| Answer» E. | |
| 595. |
What are soft drugs? |
| A. | Drugs given to babies |
| B. | Chemical drugs which are already found in the body |
| C. | Nutrients which kill the gut harmful microbes |
| D. | Anything that is not nutrients and enters the body through different routes |
| Answer» C. Nutrients which kill the gut harmful microbes | |
| 596. |
What is not a xenobiotic? |
| A. | Plant toxins |
| B. | Drugs |
| C. | Steroids |
| D. | Environmental pollutants |
| Answer» D. Environmental pollutants | |
| 597. |
MTD is |
| A. | Maximum targeted dose |
| B. | Minimum tolerated dose |
| C. | Minimum targeted dose |
| D. | Maximum tolerated dose |
| Answer» E. | |
| 598. |
Which of the following are protein components of the cytochrome P450 system? |
| A. | Heme protein CYP450 |
| B. | NADH-CYP450 reductase |
| C. | NADPH-CYP450 reductase |
| D. | A and B E. A and C |
| Answer» B. NADH-CYP450 reductase | |
| 599. |
What is the name of the process where structurally same compounds compete for the same site on an enzyme to inhibit that? |
| A. | Altered physiology |
| B. | Repression |
| C. | Non-competitive inhibition |
| D. | Competitive inhibition |
| Answer» E. | |
| 600. |
What test uses microsomal extracts from the ER for in-vitro drug metabolism studies? |
| A. | Ames test |
| B. | Biochemical tests |
| C. | Serology |
| D. | Polymorphisms |
| Answer» B. Biochemical tests | |