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MCQOPTIONS
This section includes 2539 Mcqs, each offering curated multiple-choice questions to sharpen your Current Affairs knowledge and support exam preparation. Choose a topic below to get started.
| 501. |
Low concentrations of heparin selectively interfere with the following coagulation pathway(s): |
| A. | Intrinsic pathway |
| B. | Extrinsic pathway |
| C. | Common pathway |
| D. | Both ‘A’ and ‘C’ |
| Answer» B. Extrinsic pathway | |
| 502. |
Given structure is of |
| A. | Captopril |
| B. | Enalapril |
| C. | Fosinopril |
| D. | Bepridil |
| Answer» C. Fosinopril | |
| 503. |
2-(diethylamino)-N-(2,6-dimethylphenyl) Acetamide is IUPAC name of |
| A. | Flecainide |
| B. | Atenolol |
| C. | Verapamil |
| D. | Lignocaine |
| Answer» E. | |
| 504. |
Insulin release from pancreatic β cells is augmentednby the following except: |
| A. | Ketone bodies |
| B. | Glucagon |
| C. | Vagal stimulation |
| D. | Alfa adrenergic agonists |
| Answer» E. | |
| 505. |
Organic nitrates relax vascular smooth muscle by: |
| A. | Increasing intracellular cyclic GMP |
| B. | Increasing intracellular cyclic AMP |
| C. | Decreasing intracellular cyclic AMP |
| D. | Both ‘A’ and ‘C’ are correct |
| Answer» B. Increasing intracellular cyclic AMP | |
| 506. |
Given drug is administered by the following routes except: |
| A. | Oral |
| B. | Sublingual |
| C. | Intramuscular |
| D. | Intravenous |
| Answer» D. Intravenous | |
| 507. |
Low doses of heparin prolong: |
| A. | Bleeding time |
| B. | Activated partial thromboplastin time |
| C. | Prothrombin time |
| D. | Both ‘B’ and ‘C’ |
| Answer» C. Prothrombin time | |
| 508. |
Methyldopa is |
| A. | Parasympathomimetic |
| B. | Parasympatholytic |
| C. | Sympathomimetic |
| D. | Sympatholytic |
| Answer» E. | |
| 509. |
IUPAC name of Dobutamine is |
| A. | 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol |
| B. | 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}methyl)benzene-1,2-diol |
| C. | 4-(2-{[4-(4-hydroxyphenyl)propan-2-yl]amino}ethyl)benzene-1,2-diol |
| D. | 4-(2-{[4-(4-hydroxyphenyl) propan -2-yl]amino}methyl)benzene-1,2-diol |
| Answer» B. 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}methyl)benzene-1,2-diol | |
| 510. |
Hydrazine hydrate is precursor for synthesis of |
| A. | Hydrochlorthiazide |
| B. | Acetazolamide |
| C. | Furosemide |
| D. | Ethacrinic acid |
| Answer» C. Furosemide | |
| 511. |
Long-term thiazide therapy can cause hyperglycaemia by: |
| A. | Reducing insulin release |
| B. | Interfering with glucose utilization in tissues |
| C. | Increasing sympathetic activity |
| D. | Increasing corticosteroid secretion |
| Answer» B. Interfering with glucose utilization in tissues | |
| 512. |
Actions of thyroxine include the following except: |
| A. | Induction of negative nitrogen balance |
| B. | Reduction in plasma cholesterol level |
| C. | Fall in plasma free fatty acid level |
| D. | Rise in blood sugar level |
| Answer» D. Rise in blood sugar level | |
| 513. |
_____________ is sulfhydryl moiety containing. |
| A. | Captopril |
| B. | Enalapril |
| C. | Fosinopril |
| D. | Bepridil |
| Answer» B. Enalapril | |
| 514. |
The antiarrhythmic drug which decreases both rate of depolarization (phase 0) as well as rate of repolarization (phase 3) of myocardial fibres is: |
| A. | Lignocaine |
| B. | Propranolol |
| C. | Quinidine |
| D. | Verapamil |
| Answer» D. Verapamil | |
| 515. |
Rapid intravenous injection of clonidine causes rise in BP due to: |
| A. | Stimulation of vasomotor centre |
| B. | Release of noradrenaline from adrenergic nerve endings |
| C. | Agonistic action on vascular α adrenergic receptors |
| D. | Cardiac stimulation |
| Answer» D. Cardiac stimulation | |
| 516. |
Methyldopa lowers BP by: |
| A. | Inhibiting dopa decarboxylase in adrenergic nerve endings |
| B. | Generating α-methyl noradrenaline in brain which reduces sympathetic tone |
| C. | Generating α-methyl noradrenaline which acts as a false transmitter in peripheral adrenergic nerve endings |
| D. | Activating vascular dopamine receptors |
| Answer» C. Generating α-methyl noradrenaline which acts as a false transmitter in peripheral adrenergic nerve endings | |
| 517. |
Furosemide acts by inhibiting the following in the renal tubular cell: |
| A. | Na+-K+-2Cl– cotransporter |
| B. | Na+-Cl– symporter |
| C. | Na+-H+ antiporter |
| D. | Na+ K+ ATPase |
| Answer» B. Na+-Cl– symporter | |
| 518. |
Secretion of K+ in the late distal tubule and collecting ducts of kidney depends on: |
| A. | Intracellular K+ content |
| B. | Unabsorbed Na+ load presented to the distal segment |
| C. | Aldosterone level |
| D. | All of the above |
| Answer» E. | |
| 519. |
Quinidine is now used primarily for: |
| A. | Conversion of atrial fibrillation to sinus rhythm |
| B. | Control of ventricular rate in atrial flutter |
| C. | Termination of ventricular tachycardia |
| D. | Prevention of recurrences of atrial fibrillation/ ventricular tachycardia |
| Answer» E. | |
| 520. |
Activity of cardiac glycoside depends to a great extent on |
| A. | 23rd carbonyl oxygen |
| B. | C – 3 OH |
| C. | Side chain at C – 14 |
| D. | Side chain at C – 17 |
| Answer» B. C – 3 OH | |
| 521. |
The dihydropyridines block the following type of calcium channels: |
| A. | L-type voltage sensitive channels |
| B. | T-type voltage sensitive channels |
| C. | N-type voltage sensitive channels |
| D. | Receptor operated calcium channels |
| Answer» B. T-type voltage sensitive channels | |
| 522. |
The major limitation of the thiazolidinediones in the treatment of type 2 diabetes mellitus is: |
| A. | Frequent hypoglycaemic episodes |
| B. | Hyperinsulinemia |
| C. | Lactic acidosis |
| D. | Low hypoglycaemic efficacy in moderate to severe cases |
| Answer» E. | |
| 523. |
The most significant feature of the antiarrhythmic action of is: |
| A. | Suppression of phase-4 depolarization in ventricular ectopic foci |
| B. | Prolongation of action potential duration |
| C. | Prolongation of effective refractory period |
| D. | Depression of membrane responsiveness |
| Answer» B. Prolongation of action potential duration | |
| 524. |
Given drug is |
| A. | α blocker |
| B. | β blocker |
| C. | K+ channel blocker |
| D. | Ca++ channel blocker |
| Answer» E. | |
| 525. |
The following antiarrhythmic drug has the most prominent anticholinergic action: |
| A. | Disopyramide |
| B. | Quinidine |
| C. | Procainamide |
| D. | Lignocaine |
| Answer» B. Quinidine | |
| 526. |
The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is: |
| A. | Reduction of circulating blood volume |
| B. | Reduction in cardiac output |
| C. | Decreased sympathetic tone |
| D. | Reduction in total peripheral vascular resistance and improved compliance of resistance Vessels |
| Answer» E. | |
| 527. |
Choose the most potent and most efficacious LDL cholesterol lowering HMG-CoA reductaseinhibitor: |
| A. | Lovastatin |
| B. | Simvastatin |
| C. | Pravastatin |
| D. | Atorvastatin |
| Answer» E. | |
| 528. |
Glucose entry into the cells of the following organ/tissue is highly dependent on the presence ofinsulin: |
| A. | Brain |
| B. | Liver |
| C. | Adipose tissue |
| D. | Kidney tubules |
| Answer» D. Kidney tubules | |
| 529. |
The short acting dihydropyridine preparations can aggravate myocardial ischaemia by invoking: |
| A. | Coronary vasospasm |
| B. | Thrombus formation |
| C. | Vagal activation |
| D. | Reflex sympathetic discharge to the heart |
| Answer» E. | |
| 530. |
Clofibrate is synthesized from |
| A. | o-chloro phenol |
| B. | m-chloro phenol |
| C. | p-chloro phenol |
| D. | 3,4, -dichloro phenol |
| Answer» D. 3,4, -dichloro phenol | |
| 531. |
1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol is IUPAC name of |
| A. | Atenolol |
| B. | Metoprolol |
| C. | Captopril |
| D. | Hydralazine |
| Answer» C. Captopril | |
| 532. |
The most important complication of streptokinase therapy is: |
| A. | Hypotension |
| B. | Bleeding |
| C. | Fever |
| D. | Anaphylaxis |
| Answer» C. Fever | |
| 533. |
Hydralazine is synthesized from |
| A. | 2-formyl benzoic acid and Hydrazine |
| B. | Methacrylic acid |
| C. | 2-azidoethanol |
| D. | o-nitro toluene |
| Answer» B. Methacrylic acid | |
| 534. |
Metformin belongs to which class? |
| A. | Sulphonylureas |
| B. | Meglitinide analogues |
| C. | Biguanides |
| D. | Thiazolidinediones |
| Answer» D. Thiazolidinediones | |
| 535. |
Phase II in cardiac action potential is |
| A. | Fast depolarization |
| B. | Partial repolarization |
| C. | Plateau |
| D. | Repolarization |
| Answer» D. Repolarization | |
| 536. |
IUPAC name of given drug is |
| A. | Benzoic acid, 5- (aminosulphonyl)-4-chloro-2-[(2-furanyl 1-methyl) amino] |
| B. | Benzoic acid, 3- (aminosulphonyl)-4-chloro-2-[(2-furanyl 1-methyl) amino] |
| C. | Benzoic acid, 5- (aminosulphonyl)-3-chloro-2-[(2-furanyl 1-methyl) amino] |
| D. | Benzoic acid, 3- (aminosulphonyl)-3-chloro-2-[(2-furanyl 1-methyl) amino] |
| Answer» B. Benzoic acid, 3- (aminosulphonyl)-4-chloro-2-[(2-furanyl 1-methyl) amino] | |
| 537. |
Blood flow in the following vascular bed generally decreases under the influence of glyceryl trinitrate: |
| A. | Coronary |
| B. | Cutaneous |
| C. | Renal |
| D. | Cranial |
| Answer» D. Cranial | |
| 538. |
Myocardial Na+ channel blockade by lignocaine has the following characteristic: |
| A. | It blocks inactivated Na+ channels more than activated channels |
| B. | It blocks activated Na+ channels more than inactivated channels |
| C. | It delays rate of recovery of Na+ channels |
| D. | It produces more prominent blockade of atrial than ventricular Na+ channels |
| Answer» B. It blocks activated Na+ channels more than inactivated channels | |
| 539. |
Glyceryl trinitrate is used in CHF for: |
| A. | Routine treatment of mild to moderate chronic heart failure |
| B. | Rapid symptom relief in acute left ventricular failure |
| C. | Arresting disease progression |
| D. | Both 'A' and 'B' |
| Answer» C. Arresting disease progression | |
| 540. |
Addition of non-polar group _________ partition co-efficient |
| A. | Improves |
| B. | Reduces |
| C. | No effect on |
| D. | none |
| Answer» B. Reduces | |
| 541. |
Enzyme activity is maximum during the early morning. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 542. |
D-Asparagine has sweet taste while L-Asparagine has |
| A. | Sweet taste |
| B. | Sour Taste |
| C. | Bitter Taste |
| D. | Tasteless |
| Answer» E. | |
| 543. |
Generally drugs are absorbed in which form? |
| A. | In ionized form |
| B. | In unionized form |
| C. | In both of abone form |
| D. | In none of above form |
| Answer» C. In both of abone form | |
| 544. |
Which compound is capable of forming a ring structure with metal atoms? |
| A. | Ligands |
| B. | Chelates |
| C. | Surfactants |
| D. | All of the above |
| Answer» C. Surfactants | |
| 545. |
What is the major end product of oxidation of aromatic carbon atoms? |
| A. | Arenols |
| B. | Catechol |
| C. | Glutathione |
| D. | Arene oxide |
| Answer» B. Catechol | |
| 546. |
Which of the following enzymes is not involved in catalyzing Phase I metabolic reaction? |
| A. | Flavin-containing monooxygenases |
| B. | Oxidation of alkyl groups |
| C. | Glucuronyl transferase |
| D. | Esterases |
| Answer» D. Esterases | |
| 547. |
(+) Sotalol is beta blocker while (-) Sotalol is |
| A. | beta blocker |
| B. | Analgesic |
| C. | Antidepressant |
| D. | Antiarrhythmic |
| Answer» E. | |
| 548. |
Which ester of Chloramphenicol is prepared to mask its bitter taste? |
| A. | Sodium |
| B. | Hydrochloride |
| C. | Salicylate |
| D. | Palmitate |
| Answer» E. | |
| 549. |
How many people will be selected for phase II trial? |
| A. | The whole market will be under surveillance |
| B. | 300-3000 people |
| C. | 20-300 people |
| D. | 20-50 people |
| Answer» D. 20-50 people | |
| 550. |
Higher will be the diffusion of the drug across the membrane if |
| A. | Higher value of partition-coefficient |
| B. | Low value of partition-coefficient |
| C. | Higher water soluble |
| D. | None of above |
| Answer» B. Low value of partition-coefficient | |