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MCQOPTIONS
This section includes 2539 Mcqs, each offering curated multiple-choice questions to sharpen your Current Affairs knowledge and support exam preparation. Choose a topic below to get started.
| 651. |
D-Penicillamine is antiarthritic while L-Penicillamine is |
| A. | Antiarthritic |
| B. | Antiarrhythmic |
| C. | Antidepressant |
| D. | Toxic |
| Answer» E. | |
| 652. |
(+) Warfarin is _____times more potent than (-) Warfarin. |
| A. | 2 |
| B. | 3 |
| C. | 4 |
| D. | 5 |
| Answer» E. | |
| 653. |
UDPGA means.... |
| A. | Urane diphospho -a- D glucuronic acid |
| B. | Uridine diphospho -a- D glucuronic acid |
| C. | Uridine diphospho-D glucuronic acid |
| D. | Uric diphospho -a- D glucuronic acid |
| Answer» C. Uridine diphospho-D glucuronic acid | |
| 654. |
Methyl Prednisolone is water insoluble but its which salt is water soluble? |
| A. | Sodium |
| B. | Hydrochloride |
| C. | Salicylate |
| D. | Palmitate |
| Answer» B. Hydrochloride | |
| 655. |
What injection is administered directly into systemic circulation causing rapiddistribution? |
| A. | Intramuscular |
| B. | Intravenous |
| C. | Intracerebral |
| D. | Intraspinal |
| Answer» C. Intracerebral | |
| 656. |
Oxidation of Tolbutamide is the example of |
| A. | Oxidation of Olefin |
| B. | Oxidation of Aliphatic carbon |
| C. | Oxidation of Benzylic carbon |
| D. | Oxidation of Allylic carbon |
| Answer» D. Oxidation of Allylic carbon | |
| 657. |
ω – oxidation of Valproic acid results in |
| A. | 2-hydroxy valproic acid |
| B. | 3-hydroxy valproic acid |
| C. | 4-hydroxy valproic acid |
| D. | 5-hydroxy valproic acid |
| Answer» E. | |
| 658. |
R (-) Epinephrine shows 3 point of interaction with receptor while S (+)Epinephrineshows 2 point of interaction with receptor. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 659. |
Single ascending dose studies are done in_____ |
| A. | Phase lb |
| B. | Phase Ia |
| C. | Phase II |
| D. | Phase Ila |
| Answer» C. Phase II | |
| 660. |
Bioisosteres are similar in their |
| A. | Physical character |
| B. | Chemical character |
| C. | Both character a & b |
| D. | Biochemical character |
| Answer» D. Biochemical character | |
| 661. |
Human micro dosing studies conducted in which clinical phase ? |
| A. | Phase 0 |
| B. | Phase I |
| C. | Phase II |
| D. | Phase III |
| Answer» B. Phase I | |
| 662. |
__________reaction is most common in drugs having ester or amide functional groups |
| A. | Oxidative reactions |
| B. | Reduction |
| C. | Hydrolysis |
| D. | Phase I |
| Answer» D. Phase I | |
| 663. |
Following are the Phase I reactions except ____________ |
| A. | Oxidative reactions |
| B. | Hydrolytic reactions |
| C. | Reductive reactions |
| D. | Sulphide reactions |
| Answer» E. | |
| 664. |
Which of the following statements is the closest description of Phase II metabolism? |
| A. | Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites. |
| B. | Reactions which occur in the blood supply. |
| C. | Reactions which add a polar functional group to a drug. |
| D. | Reactions which occur in the gut wall. |
| Answer» B. Reactions which occur in the blood supply. | |
| 665. |
Which of the following reactions is catalyzed by the enzyme adenylate cyclase? |
| A. | Conversion of ATP to cyclic AMP |
| B. | Conversion of cyclic AMP to AMP |
| C. | Conversion of cyclic AMP to ATP |
| D. | Conversion of AMP to cyclic AMP |
| Answer» B. Conversion of cyclic AMP to AMP | |
| 666. |
How many people will be selected for phase III trial? |
| A. | The whole market will be under surveillance |
| B. | 300-3000 people |
| C. | 20-300 people |
| D. | 20-50 people |
| Answer» C. 20-300 people | |
| 667. |
Natural products or derivatives or synthetic substances with good binding ability in Drug discovery is known as |
| A. | Hit |
| B. | Lead |
| C. | NDA |
| D. | IND |
| Answer» B. Lead | |
| 668. |
Strength of H-bond is |
| A. | 1-7 Kcal/mol |
| B. | 10-70 Kcal/mol |
| C. | 10-17 Kcal/mol |
| D. | 17-70 Kcal/mol |
| Answer» B. 10-70 Kcal/mol | |
| 669. |
Addition of polar group in a drug increases its interaction with |
| A. | Water |
| B. | Lipid |
| C. | Both |
| D. | None |
| Answer» B. Lipid | |
| 670. |
Biotransformation of drugs is defined as the conversion from one physical form toanother. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» C. none | |
| 671. |
Which one of the following will be checked under phase IV surveillance? |
| A. | The whole market will be under surveillance |
| B. | 300-3000 people |
| C. | 20-300 people |
| D. | 20-50 people |
| Answer» B. 300-3000 people | |
| 672. |
Alcohol is the inducer for which drug? |
| A. | Cortisol |
| B. | Pentobarbital |
| C. | Meprobamate |
| D. | Oral contraceptives |
| Answer» C. Meprobamate | |
| 673. |
Which of the following statements is the closest description of Phase I metabolism? |
| A. | Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites |
| B. | Reactions which occur in the blood supply. |
| C. | Reactions which add a polar functional group to a drug. |
| D. | Reactions which occur in the gut wall. |
| Answer» D. Reactions which occur in the gut wall. | |
| 674. |
Which one of the following is not an environmental agent to decrease drug metabolizing ability? |
| A. | DDT |
| B. | Cigarette smoke |
| C. | Organophosphate insecticides |
| D. | Methacholine |
| Answer» E. | |
| 675. |
Alkenes and aromatic groups can be metabolised to diols. Which enzymes are involved? |
| A. | cytochrome P450 enzymes |
| B. | epoxide hydrolase |
| C. | both of the above |
| D. | neither of the above |
| Answer» D. neither of the above | |
| 676. |
Which of the following is a fastest receptor |
| A. | Enzyme linked |
| B. | Ion- gated |
| C. | GPCR |
| D. | Nuclear |
| Answer» D. Nuclear | |
| 677. |
What are xenobiotics? |
| A. | Another form of antibiotics |
| B. | A form of nutrient |
| C. | Nutrients which kill the gut harmful microbes |
| D. | Anything that is not nutrients and enters the body through different routes |
| Answer» E. | |
| 678. |
Oxidation of Propranolol results in |
| A. | 2-hydroxy propranolol |
| B. | 3-hydroxy propranolol |
| C. | 4-hydroxy propranolol |
| D. | 2,2-Dihydroxy propranolol |
| Answer» D. 2,2-Dihydroxy propranolol | |
| 679. |
Compound with good activity and selectivity in screening during drug discovery isknown as |
| A. | Hit |
| B. | Lead |
| C. | NDA |
| D. | IND |
| Answer» C. NDA | |
| 680. |
The 3D structure elucidation is done by process |
| A. | IR |
| B. | FTIR |
| C. | NMR |
| D. | MS |
| Answer» D. MS | |
| 681. |
Which of the following reactions is not a Phase I metabolic transformation? |
| A. | Reduction of ketones |
| B. | Conjugation to alcohols |
| C. | Monoamine oxidases |
| D. | Esterhydrolysis |
| Answer» C. Monoamine oxidases | |
| 682. |
A molecule having 3 chiral centre carbon it has |
| A. | 4 set of diasters |
| B. | 9 set of enantiomers |
| C. | 6 set of monomers |
| D. | 9 set of diasters |
| Answer» C. 6 set of monomers | |
| 683. |
Reduction of given drug results in______ |
| A. | Paroxon |
| B. | Sulphanilamide |
| C. | PABA |
| D. | 7 – aminometabolite |
| Answer» E. | |
| 684. |
Which of the following is odd one regarding drug-receptor interaction |
| A. | Hydrogen bonding |
| B. | Electrostatic |
| C. | Weak Wander wall Force |
| D. | Dipole- induced dipole interaction |
| Answer» E. | |
| 685. |
The phase II reactions are detoxification pathways. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 686. |
Which of the following statements is not true about cytochrome P450 enzymes? |
| A. | They contain haem and magnesium. |
| B. | They belong to a general class of enzymes called monooxygenases. |
| C. | There are over 30 different cytochrome P450 enzymes. |
| D. | Variation in cytochrome P450 enzyme profile between individuals can explain individual variation in drug susceptibility. |
| Answer» B. They belong to a general class of enzymes called monooxygenases. | |
| 687. |
Identify the sweet odoured organic substance from the following |
| A. | Chloroform |
| B. | Acetaldehyde |
| C. | Ethyl acetate |
| D. | Acetic acid |
| Answer» D. Acetic acid | |
| 688. |
If dichloromethane (DCM) and water (H2O) are used for differential extraction, which one of the following statements is correct? |
| A. | DCM and H2O would stay as lower and upper layer respectively in the S.F. |
| B. | DCM and H2O would stay as upper and lower layer respectively in the separating funnel (S.F.) |
| C. | DCM and H2O will be miscible clearly |
| D. | DCM and H2O will make turbid/colloidal mixture |
| Answer» B. DCM and H2O would stay as upper and lower layer respectively in the separating funnel (S.F.) | |
| 689. |
Consider the van der Waals constants, a and b, for the following gases, GasArNeKrXea/(atm dm6 mol-2)1.30.25.14.1 b/(10-2 dm3 mol-1)3.21.71.05.0Which gas is expected to have the highest critical temperature? |
| A. | Kr |
| B. | Ne |
| C. | Xe |
| D. | Ar |
| Answer» B. Ne | |
| 690. |
Isotopes of an element have ________. |
| A. | Same physical properties |
| B. | Different chemical properties |
| C. | Different number of neutrons |
| D. | Different atomic number |
| Answer» D. Different atomic number | |
| 691. |
Py Qx is the formula of a compound and in it P is a metal and Q is oxygen. If x=3 and y=2, what is the formula of the fluoride of the metal ? |
| A. | P2 F3 |
| B. | P3 F2 |
| C. | P F3 |
| D. | P3 F |
| Answer» D. P3 F | |
| 692. |
In comparison to boron, beryllium has: |
| A. | Lesser nuclear charge and lesser first ionization enthalpy. |
| B. | Greater nuclear charge and lesser first ionization enthalpy |
| C. | Greater nuclear charge and greater first ionization enthalpy |
| D. | Lesser nuclear charge and greater first ionization enthalpy |
| Answer» E. | |
| 693. |
Base tastes like ________. |
| A. | Bitter |
| B. | Sour |
| C. | Sweet |
| D. | Tasteless |
| Answer» B. Sour | |
| 694. |
Chemical change is not- |
| A. | Boiling of water |
| B. | Burning of paper |
| C. | Milk getting sour |
| D. | Burning of coal |
| Answer» B. Burning of paper | |
| 695. |
Identify the correct order of size of the species: |
| A. | Br- > Se-2 > Kr > Rb+ > Sr+2 |
| B. | Se-2 > Br- > Rb+ > Kr > Sr+2 |
| C. | Se-2 > Br- > Rb+ > Sr+2 |
| D. | Se-2 > Br- > Rb+ > Kr |
| Answer» D. Se-2 > Br- > Rb+ > Kr | |
| 696. |
Limestone, chalk and marble are different forms of |
| A. | Sodium hydroxide |
| B. | Ammonium hydroxide |
| C. | Calcium carbonate |
| D. | Calcium hydroxide |
| Answer» D. Calcium hydroxide | |
| 697. |
Azotobacter is a / an: |
| A. | nitrogen fixing bacteria |
| B. | antibiotic |
| C. | sulphur fixing bacteria |
| D. | Virus |
| Answer» B. antibiotic | |
| 698. |
If an electron has spin quantum number of \(+\frac{1}{2}\) and a magnetic quantum number of -1, it can be presented in- |
| A. | s-orbital |
| B. | p-orbital |
| C. | d-orbital |
| D. | f-orbital |
| Answer» C. d-orbital | |
| 699. |
In India for making ornamental gold we use 22 carat gold. This is an alloy of |
| A. | 22 parts of gold + 2 parts of copper |
| B. | 19 parts of gold + 3 parts of copper |
| C. | 18 parts of gold + 4 parts of copper |
| D. | 17 parts of gold + 7 parts of copper |
| Answer» B. 19 parts of gold + 3 parts of copper | |
| 700. |
All acids produce ________ when dissolved in water. |
| A. | OH- ion |
| B. | H+ ion |
| C. | Electron |
| D. | Neutron |
| Answer» C. Electron | |