Characteristic unwanted reaction which isn’t related to a dose or to a pharma codynamic property of a drug is called: 

a) Idiosyncrasy 

b) Hypersensitivity 

c) Tolerance 

d) Teratogenic action 

An agonist is a substance that: 

a) Interacts with the receptor without producing any effect 

b) Interacts with the receptor and initiates changes in cell function, producing various effects 

c) Increases concentration of another substance to produce effect 

d) Interacts with plasma proteins and doesn’t produce any effect 

What does “affinity” mean? 

a) A measure of how tightly a drug binds to plasma proteins 

b) A measure of how tightly a drug binds to a receptor 

c) A measure of inhibiting potency of a drug 

d) A measure of bio availability of a drug

Tolerance develops because of: 

a) Diminished absorption 

b) Rapid excretion of a drug 

c) Both of the above 

d) None of the above

The situation when failure to continue administering the drug results in serious psychological and somatic disturbances is called? 

a) Tachyphylaxis 

b) Sensibilization 

c) Abstinence syndrome 

d) Idiosyncrasy

Drug resistance is a term used to describe the loss of effectiveness of antimicrobial or antitumour drugs. This consideration is: 

a) True 

b) False

Dependence is often associated with tolerance to a drug, a physical abstinence syndrome, and psychological dependence (craving). This consideration is: 

a) True 

b) False

What term is used to describe a decrease in responsiveness to a drug which develops in a few minutes? 

a) Refractoriness 

b) Cumulative effect 

c) Tolerance 

d) Tachyphylaxis

Therapeutic index (TI) is: 

a) A ratio used to evaluate the safety and usefulness of a drug for indication 

b) A ratio used to evaluate the effectiveness of a drug

c) A ratio used to evaluate the bio availability of a drug 

d) A ratio used to evaluate the elimination of a drug 

Tolerance and drug resistance can be a consequence of: 

a) Change in receptors, loss of them or exhaustion of mediators 

b) Increased receptor sensitivity 

c) Decreased metabolic degradation 

d) Decreased renal tubular secretion