Which of the given statement is untrue about functional genomics?

• A. Known functions are derived from experimental evidence in molecular biology and genetic studies with model organisms
• B. Non-Orthologous genes between biologically distinct species can be identified, and it is strong evidence for a related function
• C. Sequence-based methods of gene prediction can be augmented by the types of genome comparisons that are designed to identify related genes based on common patterns of expression, evolutionary profiles, chromosomal locations, and other features
• D. Genome analysis depends to a large extent on sequence analysis methods that identify gene function based on similarity between proteins of unknown function and proteins of known function