Which of the following is not an advantage of Statistical models methods in analyzing protein motifs?

• A. Sequence information is preserved from a multiple sequence alignment and expresses it with probabilistic models
• B. Statistical models allow partial matches and compensate for unobserved sequence patterns using pseudo-counts
• C. Statistical models have stronger predictive power than the regular expression based approach, even when they are derived from a limited set of sequences
• D. The comparative flexibility is less in case of these methods when compared to regular expressions methods