To improve the specificity of prediction, some algorithms selectively ______ coding regions and focus on the upstream regions________ which are most likely to contain promoters. In that sense, promoter prediction and gene prediction are coupled.

• A. include, (0.5 to 2.0 kb) onlyb) include, (0.5 to 2.0 Mb) onlyc) exclude, (0.5 to 2.0 Mb) onlyd) exclude, (0.5 to 2.0 k
• B. onlyb) include, (0.5 to 2.0 Mb) only
• C. exclude, (0.5 to 2.0 Mb) only
• D. exclude, (0.5 to 2.0 kb) only