Granting agency requires a certain level of accuracy in case of errors. Which of the given statements is untrue regarding it?

• A. In other laboratories, such as those performing a single-attempt sequencing of ESTs, the error rate may be much higher, approximately 1 in 100, including incorrectly identified bases and inserted or deleted bases
• B. Incorrect bases always translate to the right amino acid
• C. Base insertions/deletions will cause frame-shifts in the sequence
• D. Making alignment with a protein sequence becomes difficult because of frameshifts