A method of sequence alignment based on a Model (Bishop and Thompson 1986) was introduced that predicts the manner in which DNA sequences change during evolution. Which of the following is wrong about it?

• A. The basis of this method is to devise a scheme for introducing substitutions, insertions, and gaps into sequences
• B. The basis of this method is to provide a probability that each of these changes occurs over certain periods of evolutionary time
• C. Given each of these predicted changes, the method examines all the possible combinations of mutations to change one sequence into another
• D. Multiple combinations are selected that will be the most likely over time