A method of sequence alignment based on a Model (Bishop and Thompson 1986) was introduced that predicts the manner in which DNA sequences change during evolution. Which of the following is wrong about it?

• A. This method is different from the Smith-Waterman local alignment algorithm
• B. This method is quite similar to the Smith-Waterman local alignment algorithm
• C. The underlying mutational theory is like those used to produce the PAM matrices for predicting changes in DNA and protein sequences
• D. Sequences are predicted to change by a Markov process such that each mutation in the sequence is independent of previous mutations at that site or at other sites