MCQOPTIONS
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MCQOPTIONS
This section includes 13 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Which of the following is true about Gen Threader? |
| A. | It is a web-based program that uses a hybrid of the profile and pairwise energy methods |
| B. | It is a web-based program that uses profile methods only |
| C. | It is a web-based program that uses pairwise energy methods only |
| D. | The initial step is quite dissimilar to 3D-PSSM |
| Answer» B. It is a web-based program that uses profile methods only | |
| 2. |
Which of the following is untrue about 3D-PSSM? |
| A. | It is a web-based program that employs the structural profile method to identify protein folds |
| B. | The profiles for each protein superfamily are constructed by combining multiple smaller profiles |
| C. | A protein structural superfamily doesn’t have sequence-based PSI-BLAST profile |
| D. | In initial steps, protein structures in a superfamily based on the SCOP classification are superimposed |
| Answer» D. In initial steps, protein structures in a superfamily based on the SCOP classification are superimposed | |
| 3. |
There are a large number of protein folds available, compared to millions of protein sequences. |
| A. | True |
| B. | False |
| Answer» C. | |
| 4. |
WHICH_OF_THE_FOLLOWING_IS_UNTRUE_ABOUT_3D-PSSM??$ |
| A. | It is a web-based program that employs the structural profile method to identify protein folds |
| B. | The profiles for each protein superfamily are constructed by combining multiple smaller profiles |
| C. | A protein structural superfamily doesn’t have sequence-based PSI-BLAST profile |
| D. | In initial steps, protein structures in a superfamily based on the SCOP classification are superimposed |
| Answer» D. In initial steps, protein structures in a superfamily based on the SCOP classification are superimposed | |
| 5. |
Which of the following is true about Gen Threader?$ |
| A. | It is a web-based program that uses a hybrid of the profile and pairwise energy methods |
| B. | It is a web-based program that uses profile methods only |
| C. | It is a web-based program that uses pairwise energy methods only |
| D. | The initial step is quite dissimilar to 3D-PSSM |
| Answer» B. It is a web-based program that uses profile methods only | |
| 6. |
Which of the following is untrue about threading and fold recognition? |
| A. | It assess the compatibility of an amino acid sequence with a known structure in a fold library |
| B. | If the protein fold to be predicted does not exist in the fold library, the method won’t necessarily fail |
| C. | If the protein fold to be predicted does not exist in the fold library, the method will fail |
| D. | Threading and fold recognition do not generate fully refined atomic models for the query sequences |
| Answer» C. If the protein fold to be predicted does not exist in the fold library, the method will fail | |
| 7. |
Because threading and fold recognition detect structural homologs ________ relying on sequence similarities, they have been shown to be _______ than PSI-BLAST in finding distant evolutionary relationships |
| A. | without completely, far more sensitive |
| B. | completely, far more sensitive |
| C. | completely, less sensitive |
| D. | without completely, less sensitive |
| Answer» B. completely, far more sensitive | |
| 8. |
Which of the following is untrue about profile method? |
| A. | A profile is constructed for a group of related protein structures |
| B. | The propensity of amino acids in not in picture of this method |
| C. | Statistical information from these aligned residues is then used to construct a profile |
| D. | The structural profile is generated by superimposition of the structures to expose corresponding residues |
| Answer» C. Statistical information from these aligned residues is then used to construct a profile | |
| 9. |
The next step in the pairwise energy based method is to build a crude model for the target sequence by replacing aligned residues in the template structure with the corresponding residues in the query. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 10. |
In the pairwise energy based method, a protein sequence is searched for in a structural fold database to find the best matching structural fold using ______ criteria. |
| A. | sequence-based |
| B. | structure-based |
| C. | energy-based |
| D. | residue-based |
| Answer» D. residue-based | |
| 11. |
The algorithms used here can be classified into two categories, pairwise energy based and profile based. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 12. |
Threading or structural fold recognition predicts the structural fold of an unknown protein sequence by fitting the sequence into a structural database and selecting the best-fitting fold. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 13. |
There are a large number of protein folds available, compared to millions of protein sequences |
| A. | True |
| B. | False |
| Answer» C. | |