Explore topic-wise MCQs in Bioinformatics.

This section includes 9 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.

1.

Which of the following is untrue regarding PHD?

A. It stands for Profile network from Heidelberg
B. It is a web-based program that combines neural network only
C. It first performs a BLASTP of the query sequence against a non redundant protein sequence database
D. In initial steps it finds a set of homologous sequences, which are aligned with the MAXHOM program (a weighted dynamic programming algorithm performing global alignment)
Answer» C. It first performs a BLASTP of the query sequence against a non redundant protein sequence database
Discussion
2.

Which of the following is untrue regarding Prediction with Neural Networks?

A. The third-generation prediction algorithms extensively apply sophisticated neural networks
B. It is used to analyze substitution patterns in multiple sequence alignments
C. It is not a machine learning process
D. It requires a structure of multiple layers of interconnected variables or nodes
Answer» D. It requires a structure of multiple layers of interconnected variables or nodes
Discussion
3.

Because residues in the same aligned position are assumed to have the same secondary structure, any inconsistencies or errors in prediction of individual sequences can be corrected using a majority rule.

A. True
B. False
Answer» B. False
Discussion
4.

Which of the following is untrue regarding Chou Fasman and GOR methods?

A. Both are the first-generation methods
B. They are developed in the 1970s,
C. They suffer from the fact that the prediction rules are somewhat arbitrary
D. They are based on single sequence statistics with clear relation to known protein-folding theories
Answer» E.
Discussion
5.

The GOR method is based on the propensity of each residue to be in one of the two conformational states, helix (H), strand(E).

A. True
B. False
Answer» C.
Discussion
6.

The Chou Fasman algorithm determines the propensity or intrinsic tendency of each residue to be in the helix, strand, and -turn conformation using observed frequencies found in protein crystal structures.

A. True
B. False
Answer» B. False
Discussion
7.

Which of the following is untrue regarding Ab Initio Based Methods?

A. This type of method predicts the secondary structure based on a single query sequence
B. This type of method predicts the secondary structure based on a multiple query sequence
C. It measures the relative propensity of each amino acid belonging to a certain secondary structure element
D. The propensity scores are derived from known crystal structures
Answer» C. It measures the relative propensity of each amino acid belonging to a certain secondary structure element
Discussion
8.

The secondary structure prediction methods can be either ab initio based, which make use of single sequence information only, or homology based, which makes use of multiple sequence alignment information.

A. True
B. False
Answer» B. False
Discussion
9.

The formation of _____ is determined by ______ interactions, whereas the formation of ____ is strongly influenced by ______ interactions.

A. -helices, long-range, -helices, short-range
B. -helices, long-range, -strands, short-range
C. -helices, short-range, -strands, long-range
D. -strands, short-range, -strands, long-range
Answer» D. -strands, short-range, -strands, long-range
Discussion