Which of the following is untrue regarding the STRING?

It is based on combined evidence of gene linkage, gene fusion and phylogenetic profiles

Search Tool for the Retrieval of Interacting Genes/Proteins

Functional associations include only the direct protein-protein interactions

It is based on combined evidence of gene linkage, gene fusion and phylogenetic profiles

It is a web server that predicts gene and protein functional associations

Which of the following is untrue regarding the predicting Interactions Based on Phylogenetic Information?

This method detects the co-presence or co-absence of orthologs across a number of genomes

Proteins do not operate as a complex

This method detects the co-presence or co-absence of orthologs across a number of genomes

Protein interactions can be predicted using phylogenetic profiles

Phylogenetic profile are defined as patterns of gene pairs that are concurrently present or absent across genomes

Which of the following is untrue regarding the Predicting Interactions Based on Domain Fusion?

It is based on gene fusion events

Predicting protein protein interactions is called the Rosetta stone method

A fused protein often reveals relationships between its domain components

A fused protein doesn t necessarily reveal about the relationships between its domain components

Explore topic-wise MCQs in Bioinformatics.

This section includes 6 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.

1.	Which of the following is untrue regarding the STRING?
A.	Search Tool for the Retrieval of Interacting Genes/Proteins
B.	Functional associations include only the direct protein-protein interactions
C.	It is based on combined evidence of gene linkage, gene fusion and phylogenetic profiles
D.	It is a web server that predicts gene and protein functional associations
Answer» C. It is based on combined evidence of gene linkage, gene fusion and phylogenetic profiles

Discussion

2.	Which of the following is untrue regarding the predicting Interactions Based on Phylogenetic Information?
A.	Proteins do not operate as a complex
B.	This method detects the co-presence or co-absence of orthologs across a number of genomes
C.	Protein interactions can be predicted using phylogenetic profiles
D.	Phylogenetic profile are defined as patterns of gene pairs that are concurrently present or absent across genomes
Answer» B. This method detects the co-presence or co-absence of orthologs across a number of genomes

Discussion

3.	In Predicting Interactions Based on Gene Neighbors if a certain gene linkage is found to be indeed conserved across divergent genomes, it can be used as a strong indicator of formation of an operon that encodes proteins that are functionally and even physically coupled.
A.	True
B.	False
Answer» B. False

Discussion

4.	Which of the following is untrue regarding the Predicting Interactions Based on Domain Fusion?
A.	It is based on gene fusion events
B.	Predicting protein protein interactions is called the Rosetta stone method
C.	A fused protein often reveals relationships between its domain components
D.	A fused protein doesn t necessarily reveal about the relationships between its domain components
Answer» E.

Discussion

5.	An alternative approach to determining protein protein interactions is to use a large-scale affinity purification technique that involves attaching fusion tags to proteins and purifying the associated protein complexes in an affinity chromatography column.
A.	True
B.	False
Answer» B. False

Discussion

6.	If the bait and prey proteins _______ they bring the DNA-binding and trans-activation domains in such close proximity that they reconstitute the function of the transcription activator, turning ____ the expression of a reporter gene as a result. Which of the following is not the correct pair of blanks?
A.	physically interact, on
B.	do not interact, on
C.	do not interact, off
D.	stop interacting, off
Answer» C. do not interact, off

Discussion

Explore topic-wise MCQs in Bioinformatics.

Which of the following is untrue regarding the STRING?

Which of the following is untrue regarding the predicting Interactions Based on Phylogenetic Information?

In Predicting Interactions Based on Gene Neighbors if a certain gene linkage is found to be indeed conserved across divergent genomes, it can be used as a strong indicator of formation of an operon that encodes proteins that are functionally and even physically coupled.

Which of the following is untrue regarding the Predicting Interactions Based on Domain Fusion?

An alternative approach to determining protein protein interactions is to use a large-scale affinity purification technique that involves attaching fusion tags to proteins and purifying the associated protein complexes in an affinity chromatography column.