MCQOPTIONS
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MCQOPTIONS
This section includes 12 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Which of the following statements about PANTHER and TIGRFAMs databases is incorrect regarding its features? |
| A. | TIGRFAMs provides a tool for identifying functionally related proteins based on sequence homology |
| B. | TIGRFAMs is a collection of protein families, featuring curated multiple sequence alignments, hidden Markov models (HMMs) and annotation |
| C. | Hidden Markov models (HMMs) are not used in PANTHER |
| D. | PANTHER is a large collection of protein families that have been subdivided into functionally related subfamilies, using human expertise |
| Answer» D. PANTHER is a large collection of protein families that have been subdivided into functionally related subfamilies, using human expertise | |
| 2. |
Which of the following statements about CATH-Gene3D and HAMAP databases is incorrect regarding its features? |
| A. | CATH-Gene3D describes protein families and domain architectures in complete genomes |
| B. | In CATH-Gene3D the functional annotation is provided to proteins from single resource |
| C. | HAMAP profiles are manually created by expert curators they identify proteins that are part of well-conserved bacterial, archaeal and plastid-encoded proteins families or subfamilies. |
| D. | HAMAP stands for High-quality Automated and Manual Annotation of microbial Proteomes |
| Answer» C. HAMAP profiles are manually created by expert curators they identify proteins that are part of well-conserved bacterial, archaeal and plastid-encoded proteins families or subfamilies. | |
| 3. |
Which of the following statements about SCOP is incorrect regarding its features? |
| A. | Proteins with the same shapes but having little sequence or functional similarity are placed in different super families, and are assumed to have only a very distant common ancestor |
| B. | Proteins having the same shape and some similarity of sequence and/or function are placed in ‘families’, and are assumed to have a closer common ancestor |
| C. | SCOP was created in 1994 in the Centre of Protein Engineering and the University College London |
| D. | It aims to determine the evolutionary relationship between proteins |
| Answer» D. It aims to determine the evolutionary relationship between proteins | |
| 4. |
WHICH_OF_THE_FOLLOWING_STATEMENTS_ABOUT_CATH-GENE3D_AND_HAMAP_DATABASES_IS_INCORRECT_REGARDING_ITS_FEATURES??$ |
| A. | CATH-Gene3D describes protein families and domain architectures in complete genomes |
| B. | In CATH-Gene3D the functional annotation is provided to proteins from single resource |
| C. | HAMAP profiles are manually created by expert curators they identify proteins that are part of well-conserved bacterial, archaeal and plastid-encoded proteins families or subfamilies. |
| D. | HAMAP stands for High-quality Automated and Manual Annotation of microbial Proteomes |
| Answer» C. HAMAP profiles are manually created by expert curators they identify proteins that are part of well-conserved bacterial, archaeal and plastid-encoded proteins families or subfamilies. | |
| 5. |
Which_of_the_following_statements_about_PANTHER_and_TIGRFAMs_databases_is_incorrect_regarding_its_features?$ |
| A. | TIGRFAMs provides a tool for identifying functionally related proteins based on sequence homology |
| B. | TIGRFAMs is a collection of protein families, featuring curated multiple sequence alignments, hidden Markov models (HMMs) and annotation |
| C. | Hidden Markov models (HMMs) are not used in PANTHER |
| D. | PANTHER is a large collection of protein families that have been subdivided into functionally related subfamilies, using human expertise |
| Answer» D. PANTHER is a large collection of protein families that have been subdivided into functionally related subfamilies, using human expertise | |
| 6. |
Which of the following statements about PRINTS and ProDom databases is incorrect regarding its features? |
| A. | PRINTS is a compendium of protein fingerprints |
| B. | Usually the motifs do not overlap, but are separated along a sequence, though they may be contiguous in 3D-space |
| C. | Current versions of ProDom are built using a novel procedure based on recursive BLAST searches |
| D. | ProDom domain database consists of an automatic compilation of homologous domains |
| Answer» D. ProDom domain database consists of an automatic compilation of homologous domains | |
| 7. |
Which of the following statements about SUPERFAMILY database is incorrect regarding its features? |
| A. | Sequences can be submitted raw or FASTA format |
| B. | Sequences must be submitted in FASTA format only |
| C. | It searches the database using a superfamily, family, or species name plus a sequence, SCOP, PDB or HMM ID’s |
| D. | It has generated GO annotations for evolutionarily closed domains and distant domains |
| Answer» C. It searches the database using a superfamily, family, or species name plus a sequence, SCOP, PDB or HMM ID‚Äö√Ñ√∂‚àö√ë‚àö¬•s | |
| 8. |
What is the source of protein structures in SCOP and CATH? |
| A. | Uniprot |
| B. | Protein Data Bank |
| C. | Ensemble |
| D. | InterPro |
| Answer» C. Ensemble | |
| 9. |
Which of the following is not a member database of InterPro? |
| A. | SCOP |
| B. | HAMAP |
| C. | PANTHER |
| D. | Pfam |
| Answer» B. HAMAP | |
| 10. |
Pfam is available at four locations around the world. Which of the following is not one of them? |
| A. | UK |
| B. | Sweden |
| C. | US |
| D. | Japan |
| Answer» E. | |
| 11. |
Which of the following statements about InterPro is incorrect regarding its features? |
| A. | Protein relatedness is defined by the P-values from the BLAST alignments |
| B. | The most closely related sequences are grouped into the lowest level clusters |
| C. | More distant protein groups are merged into higher levels of clusters |
| D. | The outcome of this cluster merging is a tree-like structure of functional categories |
| Answer» B. The most closely related sequences are grouped into the lowest level clusters | |
| 12. |
Which of the following statements about COG is incorrect regarding its features? |
| A. | Currently, there are 4,873 clusters in the COG databases derived from unicellular organisms |
| B. | It is constructed by comparing protein sequences encoded in forty-three completely sequenced genomes, which are mainly from prokaryotes, representing thirty major phylogenetic lineages |
| C. | The interface for sequence searching in the COG database is the COGnitor program, which is based on gapped BLAST |
| D. | It is a protein family database based on structural classification |
| Answer» E. | |