Explore topic-wise MCQs in Bioinformatics.

This section includes 9 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.

1.

Which of the following is untrue about PhyloCon?

A. It stands for Phylogenetic Consensus
B. It is used to identify regulatory motifs
C. It is a UNIX program that combines phylogenetic footprinting with gene expression profiling analysis
D. No conservation among orthologous genes and conservation among coregulated genes is a disadvantage
Answer» E.
Discussion
2.

INCLUSive is a suite of web based tools designed to streamline the process of microarray data collection and sequence motif detection.

A. True
B. False
Answer» B. False
Discussion
3.

Which of the following is untrue about Expression Profiling Based Method?

A. Genes with similar expression profiles are considered coexpressed, which can be identified through a clustering approach
B. This approach appears to be less effective for finding transcription factor binding sites
C. An advanced alignment-independent profile construction method such as EM and Gibbs motif sampling is often used in finding the subtle sequence motifs
D. The basis for coexpression is thought to be due to common promoters and regulatory elements
Answer» C. An advanced alignment-independent profile construction method such as EM and Gibbs motif sampling is often used in finding the subtle sequence motifs
Discussion
4.

Which of the following is untrue about FootPrinter?

A. It is a web-based program for phylogenetic footprinting using multiple input sequences
B. The motifs from organisms spanning over the widest evolutionary distances are identified as promoter or regulatory motifs
C. The program performs multiple alignment of the input sequences to identify conserved motifs
D. The user does not necessarily provides a phylogenetic tree that defines the evolutionary relationship of the input sequences
Answer» E.
Discussion
5.

Which of the following is untrue about Bayes Aligner?

A. Posterior probability values, which are considered estimates of the true alignment, are calculated for each alignment
B. The method generates a single best alignment
C. It aligns two sequences using a Bayesian algorithm which is a unique sequence alignment method
D. It is a web-based footprinting program
Answer» C. It aligns two sequences using a Bayesian algorithm which is a unique sequence alignment method
Discussion
6.

rVISTA uses two orthologous sequences as input and first identifies all putative regulatory motifs based on TRANSFAC matches.

A. True
B. False
Answer» B. False
Discussion
7.

Which of the following is untrue about ConSite?

A. It is a web server that finds putative promoter elements
B. It includes comparing two orthologous sequences
C. The program does not accept pre-computed alignment
D. The program accepts pre-computed alignment
Answer» D. The program accepts pre-computed alignment
Discussion
8.

A caveat of phylogenetic footprinting is to extract noncoding sequences Upstream of corresponding genes and focus the comparison to this region only, which helps to prevent false positives.

A. True
B. False
Answer» B. False
Discussion
9.

Which of the following is incorrect regarding Phylogenetic Footprinting Based Method?

A. It is possible to obtain promoter sequences for a particular gene through comparative analysis
B. The conservation from closely related organisms is both at the sequence level and at the level of organization of the elements
C. The conservation from closely related organisms is most at the sequence level
D. It has been observed that promoter and regulatory elements from closely related organisms such as human and mouse are highly conserved
Answer» D. It has been observed that promoter and regulatory elements from closely related organisms such as human and mouse are highly conserved
Discussion