MCQOPTIONS
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MCQOPTIONS
This section includes 14 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
TIGR TM4 is a suite of multiplatform programs for analyzing microarray data. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 2. |
Which of the following is incorrect about Self-Organizing Maps? |
| A. | Clustering by SOMs is in principle similar to the k-means method |
| B. | It doesn’t involve neural networks |
| C. | The data points are initially assigned to the nodes at random |
| D. | It starts by defining a number of nodes |
| Answer» C. The data points are initially assigned to the nodes at random | |
| 3. |
Which of the following is incorrect about k-Means Clustering? |
| A. | k-means clustering produces a dendrogram |
| B. | It classifies data through a single step partition |
| C. | It is a divisive approach |
| D. | In this method, data are partitioned into k-clusters, which are prespecified at the outset |
| Answer» B. It classifies data through a single step partition | |
| 4. |
A supervised analysis refers to classification of data into a set of predefined categories. For example, depending on the purpose of the experiment, the data can be classified into predefined ‘diseased’ or ‘normal’ categories. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 5. |
In the analysis of microarray data–If replicated datasets are available, rigorous statistical tests such as t-test and analysis of variance (ANOVA) can be performed to test the null hypothesis that a given data point is not significantly different from the mean of the data distribution. |
| A. | can be performed to test the null hypothesis that a given data point is not significantly different from the mean of the data distribution.a) True |
| B. | False |
| Answer» B. False | |
| 6. |
WHICH_OF_THE_FOLLOWING_IS_INCORRECT_ABOUT_SELF-ORGANIZING_MAPS??$ |
| A. | Clustering by SOMs is in principle similar to the k-means method |
| B. | It doesn’t involve neural networks |
| C. | The data points are initially assigned to the nodes at random |
| D. | It starts by defining a number of nodes |
| Answer» C. The data points are initially assigned to the nodes at random | |
| 7. |
TIGR_TM4_is_a_suite_of_multiplatform_programs_for_analyzing_microarray_data.$ |
| A. | True |
| B. | False |
| Answer» B. False | |
| 8. |
Which of the following is incorrect about Hierarchical Clustering? |
| A. | The tree-branching pattern illustrates a higher degree of relationship between related gene groups |
| B. | It is not similar to the distance phylogenetic tree-building method |
| C. | It produces a treelike structure that represents a hierarchy or relative relatedness of data groups |
| D. | In the tree leaves, similar gene expression profiles are placed more closely together than dissimilar gene expression profiles |
| Answer» C. It produces a treelike structure that represents a hierarchy or relative relatedness of data groups | |
| 9. |
A supervised analysis refers to classification of data into a set of predefined categories. For example, depending on the purpose of the experiment, the data can be classified into predefined ‘diseased’ or ‘normal’ categories.$ |
| A. | True |
| B. | False |
| Answer» B. False | |
| 10. |
Which of the following is incorrect about Classification of microarray data? |
| A. | For microarray data, clustering analysis identifies coexpressed and coregulated genes |
| B. | For microarray data, clustering analysis identifies coexpressed but not coregulated genes |
| C. | For microarray data, clustering analysis identifies and coregulated but not coexpressed genes |
| D. | Genes within a category have more similarity in expression than genes from different categories. |
| Answer» B. For microarray data, clustering analysis identifies coexpressed but not coregulated genes | |
| 11. |
In the analysis of microarray data–If replicated datasets are available, rigorous statistical tests such as t-test and analysis of variance (ANOVA) can be performed to test the null hypothesis that a given data point is not significantly different from the mean of the data distribution.$ |
| A. | True |
| B. | False |
| Answer» B. False | |
| 12. |
Which of the following is incorrect about Data Collection? |
| A. | The two-color microarray uses multiple dyes at times |
| B. | The most common type of microarray protocol is the two-color microarray |
| C. | The cDNAs are obtained by extracting total RNA or mRNA from tissues or cells and incorporating fluorescent dyes in the DNA strands during the cDNA biosynthesis |
| D. | The expression of genes is measured via the signals from cDNAs hybridizing with the specific oligonucleotide probes on the microarray |
| Answer» B. The most common type of microarray protocol is the two-color microarray | |
| 13. |
which of the following is incorrect about Oligonucleotide Design in A microarray? |
| A. | DNA microarrays are generated by fixing oligonucleotides onto a solid support |
| B. | The oligonucleotide array slide represents thousands of preselected genes from an organism |
| C. | The length of oligonucleotides is typically in the range of twenty-five to seventy bases long |
| D. | The oligonucleotides don’t react with cDNA samples |
| Answer» E. | |
| 14. |
Which of the following is incorrect about a microarray? |
| A. | It is a slide attached with a high-density array of immobilized DNA oligomers representing the entire genome of the species under study |
| B. | Array of immobilized DNA oligomers cannot be cDNAs |
| C. | Each oligomer is spotted on the slide and serves as a probe for binding to a unique complementary cDNA |
| D. | It is the most commonly used global gene expression profiling method |
| Answer» C. Each oligomer is spotted on the slide and serves as a probe for binding to a unique complementary cDNA | |