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This section includes 13 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.
1. |
Although MOTIF program is used successfully for making the BLOCKS database, it is limited in the pattern sizes that can be found. |
A. | True |
B. | False |
Answer» B. False | |
2. |
The pattern searching method type of analysis was performed on groups of related proteins, and the amino acid patterns that were located may be found in the Prosite catalog. |
A. | True |
B. | False |
Answer» B. False | |
3. |
The program Profilemake can be used to produce a profile from an MSA. |
A. | True |
B. | False |
Answer» B. False | |
4. |
ALTHOUGH_MOTIF_PROGRAM_IS_USED_SUCCESSFULLY_FOR_MAKING_THE_BLOCKS_DATABASE,_IT_IS_LIMITED_IN_THE_PATTERN_SIZES_THAT_CAN_BE_FOUND.?$ |
A. | True |
B. | False |
Answer» B. False | |
5. |
Which_of_the_following_is_not_true_regarding_the_BLOCKS?$ |
A. | The BLOCKS server can extract a conserved, ungapped region from a MSA to produce a sequence block |
B. | The server can also find blocks in a set of unaligned, input sequences and maintains a large database of blocks based on an analysis of proteins in the Prosite catalog |
C. | Blocks are found by the Protomat program |
D. | The program MOTIF doesn’t locate spaced patterns |
Answer» E. | |
6. |
The pattern searching method type of analysis was performed on groups of related proteins, and the amino acid patterns that were located may be found in the Prosite catalog? |
A. | True |
B. | False |
Answer» B. False | |
7. |
Which of the following is not true regarding the BLOCKS? |
A. | Blocks of width 10–55 are extracted from a protein MSA |
B. | The protein MSA is up to 400 sequences |
C. | The program doesn’t accept manually reformatted MSAs |
D. | The program accepts FASTA format |
Answer» D. The program accepts FASTA format | |
8. |
In the method of extraction of blocks from a global or local MSA, a global MSA of related protein sequences usually includes regions that have been aligned without gaps in any of the sequences. |
A. | True |
B. | False |
Answer» B. False | |
9. |
Block analysis methods use substitution matrices such as the PAM and BLOSUM matrices to score matches. |
A. | True |
B. | False |
Answer» C. | |
10. |
Which of the following is untrue regarding the block analysis method? |
A. | Blocks represent a conserved region in the MSA |
B. | Blocks differ from profiles in lacking insert and delete positions in the sequences |
C. | Every column includes only matches and mismatches |
D. | Blocks may be made by searching for a section of an MSA alignment that is low conserved |
Answer» E. | |
11. |
The program Profilemake can be used to produce a profile from a MSA |
A. | True |
B. | False |
Answer» B. False | |
12. |
Profiles are found by performing the _____ MSA of a group of sequences and then removing the _______ regions in the alignment into a smaller MSA. |
A. | local, more highly conserved |
B. | global, low conserved |
C. | global, more highly conserved |
D. | local, low conserved |
Answer» D. local, low conserved | |
13. |
Which of the following is not among the methods for finding localized sequence similarity? |
A. | Profile Analysis |
B. | Block Analysis |
C. | Extraction of Blocks from a Global or Local MSA |
D. | Pattern blocking |
Answer» E. | |