Explore topic-wise MCQs in Bioinformatics.

This section includes 16 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.

1.

Nussinov and Jacobson (1980) were the first to design a precise and efficient algorithm for predicting secondary structure.

A. True
B. False
Answer» B. False
Discussion
2.

In 1971, first estimation of the energy associated with regions of secondary structure by extrapolation from studies with small molecules was done and then an attempt was made to predict which configurations of larger molecules were the most energetically stable.

A. True
B. False
Answer» B. False
Discussion
3.

Martinez (1984) made a list of possible double-stranded regions, and these regions were then given weights in proportion to their equilibrium constants, calculated by ______

A. the Boltzmann function [exp (-∆G/RT2)]
B. the Boltzmann function [exp (-∆G/RT)]
C. the Boltzmann function [exp (-∆G/RT -T)]
D. the Boltzmann function [exp (∆G/RT)]
Answer» C. the Boltzmann function [exp (-∆G/RT -T)]
Discussion
4.

The third assumption in predicting RNA secondary structure is that the structure is assumed to be formed by _____ of the chain back on itself in a manner that ________

A. crossing, produces knots
B. crossing, does not produce any knots
C. folding, produces knots
D. folding, does not produce any knots
Answer» E.
Discussion
5.

The Second assumption in predicting RNA secondary structure is that the energy associated with any position in the structure is _____ influenced by local sequence and structure.

A. only
B. not at all
C. partially
D. never
Answer» B. not at all
Discussion
6.

In predicting RNA secondary structure, some simplifying assumptions are usually made, like the _____ structure is similar to the _____

A. most likely, energetically most unstable structure
B. most unlikely, energetically most stable structure
C. most likely, energetically most stable structure
D. least likely, energetically most stable structure
Answer» D. least likely, energetically most stable structure
Discussion
7.

IN_1971,_FIRST_ESTIMATION_OF_THE_ENERGY_ASSOCIATED_WITH_REGIONS_OF_SECONDARY_STRUCTURE_BY_EXTRAPOLATION_FROM_STUDIES_WITH_SMALL_MOLECULES_WAS_DONE_AND_THEN_ATTEMPT_WAS_MADE_TO_PREDICT_WHICH_CONFIGURATIONS_OF_LARGER_MOLECULES_WERE_THE_MOST_ENERGETICALLY_STABLE.?$

A. True
B. False
Answer» B. False
Discussion
8.

Nussinov_and_Jacobson_(1980)_were_the_first_to_design_a_precise_and_efficient_algorithm_for_predicting_secondary_structure.$

A. True
B. False
Answer» B. False
Discussion
9.

Martinez (1984) made a list of possible double-stranded regions, and these regions were then given weights in proportion to their equilibrium constants, calculated by _____?

A. the Boltzmann function [ exp (-∆G/RT2) ].
B. the Boltzmann function [ exp (-∆G/RT) ].
C. the Boltzmann function [ exp (-∆G/RT -T) ].
D. the Boltzmann function [ exp (∆G/RT) ].
Answer» C. the Boltzmann function [ exp (-‚Äö√Ñ√∂‚àö‚Ć‚àö√∫G/RT -T) ].
Discussion
10.

The third assumption in predicting RNA secondary structure is that, the structure is assumed to be formed by _____ of the chain back on itself in a manner that ________

A. crossing, produces knots
B. crossing, does not produce any knots
C. folding, produces knots
D. folding, does not produce any knots
Answer» E.
Discussion
11.

The Second assumption in predicting RNA secondary structure is that, the energy associated with any position in the structure is _____ influenced by local sequence and structure.

A. only
B. not at all
C. partially
D. never
Answer» B. not at all
Discussion
12.

In predicting RNA secondary structure, some simplifying assumptions are usually made, like–the _____ structure is similar to the _____$

A. most likely, energetically most unstable structure
B. most unlikely, energetically most stable structure
C. most likely, energetically most stable structure
D. least likely, energetically most stable structure
Answer» D. least likely, energetically most stable structure
Discussion
13.

____ wobble pairs may be produced in these double-stranded regions.

A. A/A
B. A/U
C. G/C
D. G/U
Answer» E.
Discussion
14.

RNA secondary structure is composed primarily of triple-stranded RNA regions formed by folding the single-stranded molecule back twice on itself.

A. True
B. False
Answer» C.
Discussion
15.

A type of RNA secondary structure prediction method takes into account conserved patterns of base-pairing that are conserved during evolution of a given class of RNA molecules.

A. True
B. False
Answer» B. False
Discussion
16.

Which of the following is incorrect about the RNA structure prediction?

A. Given the sequence, it provides an ab initio prediction of secondary structure
B. From the many possible choices of complementary sequences that can potentially base-pair, the compatible sets that provide the highest energy molecules are chosen
C. Structures with energies almost as stable as the most stable one may also be produced
D. Regions whose predictions are the most reliable can be identified from such an analysis
Answer» C. Structures with energies almost as stable as the most stable one may also be produced
Discussion