MCQOPTIONS
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MCQOPTIONS
This section includes 9 Mcqs, each offering curated multiple-choice questions to sharpen your Biotechnology knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
What are the major stability problems which result in poor bioavailability of any orally administered drugs? |
| A. | Acidic degradation |
| B. | Degradation by salivary amylase |
| C. | Degradation of the drug in inactive form |
| D. | Interaction with the excipients and degradation in an inactive form |
| Answer» E. | |
| 2. |
Drug having a small partition coefficient can rapidly penetrate the lipid membrane but diffusion through the unstirred water layer is a rate-limiting step. |
| A. | True |
| B. | False |
| Answer» C. | |
| 3. |
What will be in the place of ‘?’ in the given picture? |
| A. | Plasma layer |
| B. | Aqueous unstirred diffusion layer |
| C. | Lipid membrane |
| D. | Blood vessel |
| Answer» C. Lipid membrane | |
| 4. |
What could be the reason that irrespective of pH any drug gets absorbed mostly from the intestine? |
| A. | More surface area |
| B. | Long residence time |
| C. | Large surface area and long residence time |
| D. | Large surface area, long residence time, basic pH |
| Answer» D. Large surface area, long residence time, basic pH | |
| 5. |
Acidic drugs are best absorbed through the stomach and basic drugs are best absorbed through the intestine. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 6. |
What helps the ionized drug molecules to pass through the cell membrane passively? |
| A. | Different pH |
| B. | Polar group |
| C. | Large lipophilic group |
| D. | Hydration |
| Answer» D. Hydration | |
| 7. |
According to the pH-partition theory which form of the drug gets absorbed mostly? |
| A. | Hydrated form |
| B. | Aggregated form |
| C. | Ionised |
| D. | Unionised |
| Answer» E. | |
| 8. |
A microclimate pH, different from the luminal pH exists at the membrane surface. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 9. |
Which one of these options is not one of the limitations of pH-partition theory? |
| A. | Presence if virtual membrane pH |
| B. | Absorption of ionized drugs |
| C. | Influence of GI surface area |
| D. | Dissolution rate |
| Answer» E. | |