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This section includes 6 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.
1. |
Nussinov and Jacobson (1980) were the first to design a precise and efficient algorithm for predicting secondary structure. |
A. | True |
B. | False |
Answer» B. False | |
2. |
In 1971, first estimation of the energy associated with regions of secondary structure by extrapolation from studies with small molecules was done and then an attempt was made to predict which configurations of larger molecules were the most energetically stable. |
A. | True |
B. | False |
Answer» B. False | |
3. |
Martinez (1984) made a list of possible double-stranded regions, and these regions were then given weights in proportion to their equilibrium constants, calculated by ______ |
A. | the Boltzmann function [exp (- G/RT2)] |
B. | the Boltzmann function [exp (- G/RT)] |
C. | the Boltzmann function [exp (- G/RT -T)] |
D. | the Boltzmann function [exp ( G/RT)] |
Answer» C. the Boltzmann function [exp (- G/RT -T)] | |
4. |
The third assumption in predicting RNA secondary structure is that the structure is assumed to be formed by _____ of the chain back on itself in a manner that ________ |
A. | crossing, produces knots |
B. | crossing, does not produce any knots |
C. | folding, produces knots |
D. | folding, does not produce any knots |
Answer» E. | |
5. |
The Second assumption in predicting RNA secondary structure is that the energy associated with any position in the structure is _____ influenced by local sequence and structure. |
A. | only |
B. | not at all |
C. | partially |
D. | never |
Answer» B. not at all | |
6. |
In predicting RNA secondary structure, some simplifying assumptions are usually made, like the _____ structure is similar to the _____ |
A. | most likely, energetically most unstable structure |
B. | most unlikely, energetically most stable structure |
C. | most likely, energetically most stable structure |
D. | least likely, energetically most stable structure |
Answer» D. least likely, energetically most stable structure | |