Explore topic-wise MCQs in Bioinformatics.

This section includes 13 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.

1.

The whole genome shotgun approach can produce a draft sequence very rapidly because it is based on the direct sequencing approach.

A. True
B. False
Answer» B. False
Discussion
2.

The hierarchical approach is ____ and _____ than the shotgun approach because it involves an initial clone-based physical mapping step.

A. slower, less costly
B. faster, more costly
C. faster, less costly
D. slower, more costly
Answer» E.
Discussion
3.

In hierarchical genome sequencing approach, based on the results of _______ mapping _______of the BAC clones on a chromosome can be determined.

A. physical, the locations and orders
B. physical, only the locations
C. cytological, only the locations
D. physical, only the orders
Answer» B. physical, only the locations
Discussion
4.

THE_HIERARCHICAL_APPROACH_IS______AND_______THAN_THE_SHOTGUN_APPROACH_BECAUSE_IT_INVOLVES_AN_INITIAL_CLONE-BASED_PHYSICAL_MAPPING_STEP.?$

A. slower, less costly
B. faster, more costly
C. faster, less costly
D. slower, more costly
Answer» E.
Discussion
5.

The_whole_genome_shotgun_approach_can_produce_a_draft_sequence_very_rapidly_because_it_is_based_on_the_direct_sequencing_approach.$

A. True
B. False
Answer» B. False
Discussion
6.

In hierarchical genome sequencing approach, based on the results of _______ mapping, _______of the BAC clones on a chromosome can be determined?

A. physical, the locations and orders
B. physical, only the locations
C. cytological, only the locations
D. physical, only the orders
Answer» B. physical, only the locations
Discussion
7.

The hierarchical genome sequencing approach is ______

A. entirely dissimilar to the shotgun approach
B. dissimilar to the shotgun approach
C. similar to the shotgun approach, but on a larger scale
D. similar to the shotgun approach, but on a smaller scale
Answer» E.
Discussion
8.

Despite the multiple coverage, sometimes certain genomic regions remain unsequenced, mainly owing to cloning difficulties.

A. True
B. False
Answer» B. False
Discussion
9.

The shotgun approach does not require knowledge of physical mapping of the clone fragments, but rather a robust computer assembly program to join the pieces of random fragments into a single, whole-genome sequence.

A. True
B. False
Answer» B. False
Discussion
10.

The shotgun approach _______ sequences clones from _____ of cloned DNA.

A. randomly, one end
B. randomly, both ends
C. specifically, both ends
D. specifically, one end
Answer» C. specifically, both ends
Discussion
11.

In DNA sequencing, the fluorescent traces of the DNA sequences are read by a computer program that assigns bases for each peak in a chromatogram.

A. True
B. False
Answer» B. False
Discussion
12.

Which of the following is untrue about DNA sequencing?

A. It is now routinely carried out using the Sanger method
B. This doesn’t make use of DNA polymerases
C. This involves synthesis of DNA chains of varying length
D. The DNA synthesis is stopped by adding dideoxynucleotides
Answer» C. This involves synthesis of DNA chains of varying length
Discussion
13.

The _____ resolution genome map is the genomic DNA sequence that can be considered as a type of ______ map describing a genome at the single base-pair level.

A. highest, physical
B. lowest, physical
C. highest, cytological
D. lowest, cytological
Answer» B. lowest, physical
Discussion