Which of the following is true regarding Protein flexibility?

Methods have been described for the introduction of side-chain flexibility to protein-ligand docking only

Methods have been described for the introduction of side-chain flexibility to both protein-ligand and protein-protein docking

Methods have been described for the introduction of side-chain flexibility to protein-ligand docking only

The Mean Field principle is rarely used in this

Methods have been described for the introduction of side-chain flexibility to protein-protein docking only

Explore topic-wise MCQs in Bioinformatics.

This section includes 5 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.

1.	Which of the following is true regarding Protein flexibility?
A.	Methods have been described for the introduction of side-chain flexibility to both protein-ligand and protein-protein docking
B.	Methods have been described for the introduction of side-chain flexibility to protein-ligand docking only
C.	The Mean Field principle is rarely used in this
D.	Methods have been described for the introduction of side-chain flexibility to protein-protein docking only
Answer» B. Methods have been described for the introduction of side-chain flexibility to protein-ligand docking only

Discussion

2.	Stochastic methods can guarantee reaching a global optimal solution and the methods are computationally costly in comparison to the other methods.
A.	True
B.	False
Answer» C.

Discussion

3.	Genetic methods (genetic algorithms and evolutionary programming) store multiple solutions. These solutions form a population of members.
A.	True
B.	False
Answer» B. False

Discussion

4.	In a Monte Carlo simulation the score (or energy) is calculated at each step and compared to the previous step. The probability of accepting the step is given by _________ where E is the difference in energy; kB is Boltzmann s constant and T the temperature.
A.	True
B.	False
Answer» B. False

Discussion

5.	The disadvantage of Multiple conformation rigid-body method is that the active conformation may be missed as the result of a minor structural difference not considered in the ______ ligand conformations. Where, the N is the number of low-energy conformations.
A.	N +1
B.	N
C.	N<sup>2</sup>
D.	N/2
Answer» C. N<sup>2</sup>

Discussion

Explore topic-wise MCQs in Bioinformatics.

Which of the following is true regarding Protein flexibility?

Stochastic methods can guarantee reaching a global optimal solution and the methods are computationally costly in comparison to the other methods.

Genetic methods (genetic algorithms and evolutionary programming) store multiple solutions. These solutions form a population of members.

In a Monte Carlo simulation the score (or energy) is calculated at each step and compared to the previous step. The probability of accepting the step is given by _________ where E is the difference in energy; kB is Boltzmann s constant and T the temperature.

The disadvantage of Multiple conformation rigid-body method is that the active conformation may be missed as the result of a minor structural difference not considered in the ______ ligand conformations. Where, the N is the number of low-energy conformations.