MCQOPTIONS
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MCQOPTIONS
This section includes 5 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Which of the following is true regarding Protein flexibility? |
| A. | Methods have been described for the introduction of side-chain flexibility to both protein-ligand and protein-protein docking |
| B. | Methods have been described for the introduction of side-chain flexibility to protein-ligand docking only |
| C. | The Mean Field principle is rarely used in this |
| D. | Methods have been described for the introduction of side-chain flexibility to protein-protein docking only |
| Answer» B. Methods have been described for the introduction of side-chain flexibility to protein-ligand docking only | |
| 2. |
Stochastic methods can guarantee reaching a global optimal solution and the methods are computationally costly in comparison to the other methods. |
| A. | True |
| B. | False |
| Answer» C. | |
| 3. |
Genetic methods (genetic algorithms and evolutionary programming) store multiple solutions. These solutions form a population of members. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 4. |
In a Monte Carlo simulation the score (or energy) is calculated at each step and compared to the previous step. The probability of accepting the step is given by _________ where E is the difference in energy; kB is Boltzmann s constant and T the temperature. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 5. |
The disadvantage of Multiple conformation rigid-body method is that the active conformation may be missed as the result of a minor structural difference not considered in the ______ ligand conformations. Where, the N is the number of low-energy conformations. |
| A. | N +1 |
| B. | N |
| C. | N<sup>2</sup> |
| D. | N/2 |
| Answer» C. N<sup>2</sup> | |