MCQOPTIONS
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MCQOPTIONS
This section includes 18 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Genes involved in the same metabolic pathway tend to be clustered among phylogenetically diverse organisms. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 2. |
Which of the following is untrue about Gene Order Comparison? |
| A. | When the order of a number of linked genes is conserved between genomes, it is called synteny |
| B. | Generally, gene order is much more conserved compared with gene sequences |
| C. | Generally, gene order is much less conserved compared with gene sequences |
| D. | It is in fact rarely observed among divergent species |
| Answer» C. Generally, gene order is much less conserved compared with gene sequences | |
| 3. |
Within-Genome Approach is to identify regions within a genome with unusual compositions. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 4. |
A way to discern lateral gene transfer is through phylogenetic analysis, referred to as an ‘among-genome’ approach, which can be used to discover __________ |
| A. | recent lateral gene transfer events but almost negligible ancient events |
| B. | recent lateral gene transfer events |
| C. | ancient lateral gene transfer events |
| D. | both recent and ancient lateral gene transfer events |
| Answer» E. | |
| 5. |
Which of the following is untrue about Lateral gene transfer? |
| A. | It is also known as vertical gene transfer |
| B. | There is exchange of genetic materials between species |
| C. | It mainly occurs among prokaryotic organisms when foreign genes are acquired through mechanisms |
| D. | It is one of the examples is transformation |
| Answer» B. There is exchange of genetic materials between species | |
| 6. |
Coregenes is a web-based program that determines a ________ set of genes based on comparison of ________ small genomes. |
| A. | vast, four |
| B. | core, fifteen |
| C. | core, four |
| D. | vast, fifteen |
| Answer» D. vast, fifteen | |
| 7. |
A minimal constitutes genome, which is a _____ set of genes required for maintaining a free living cellular organism. |
| A. | maximum |
| B. | maximal |
| C. | highest number of set of |
| D. | minimal |
| Answer» E. | |
| 8. |
Which of the following is untrue about LAGAN? |
| A. | It stands for Limited Area Global Alignment of Nucleotides |
| B. | It is a web-based program designed for pairwise alignment of small fragments of genomes only |
| C. | It first finds anchors between two genomic sequences using an algorithm that identifies short, exactly matching words |
| D. | Regions that have high density of words are selected as anchors |
| Answer» C. It first finds anchors between two genomic sequences using an algorithm that identifies short, exactly matching words | |
| 9. |
Which of the following is untrue about Whole Genome Alignment? |
| A. | This helps to reveal the presence of conserved functional elements |
| B. | It doesn’t help to understand sequence conservation between genomes |
| C. | It be accomplished through direct genome comparison or genome alignment |
| D. | The alignment at the genome level is fundamentally no different from the basic sequence alignment |
| Answer» C. It be accomplished through direct genome comparison or genome alignment | |
| 10. |
Which of the following is untrue about comparative genomics? |
| A. | It is comparison of whole genomes from different organisms |
| B. | It includes comparison of gene number, gene location, and gene content from these genomes |
| C. | It provides insights into the mechanism of genome evolution and gene transfer among genomes |
| D. | It doesn’t help to reveal the extent of conservation among genomes |
| Answer» D. It doesn’t help to reveal the extent of conservation among genomes | |
| 11. |
THE_ALL-AGAINST-ALL_ANALYSES_PROVIDE_AN_INDICATION_AS_TO_THE_NUMBER_OF_PROTEIN/GENE_FAMILIES_IN_AN_ORGANISM._THIS_NUMBER_REPRESENTS_THE_CORE_PROTEOME_OF_THE_ORGANISM_FROM_WHICH_ALL_BIOLOGICAL_FUNCTIONS_HAVE_DIVERSIFIED.?$ |
| A. | True |
| B. | False |
| Answer» B. False | |
| 12. |
WHICH_OF_THE_GIVEN_STATEMENTS_IS_INCORRECT_ABOUT_CLUSTERING_BY_SINGLE_LINKAGE??$ |
| A. | In First step, a group of related sequences found in the all-against-all proteome comparison is subjected to a multiple sequence alignment usually by CLUSTALW |
| B. | A neighbor-joining algorithm is rarely used in this method |
| C. | This procedure and the algorithms are the same as those used to make a phylogenetic tree by the distance methods |
| D. | A distance matrix that shows the number of amino acid changes between each pair of sequences is made |
| Answer» C. This procedure and the algorithms are the same as those used to make a phylogenetic tree by the distance methods | |
| 13. |
Which of the given statements is incorrect about Clustering by making subgraphs? |
| A. | Each sequence is a vertex and each pair of sequences that is matched with a significant alignment score is joined by an edge that is weighted according to the statistical significance of the alignment score |
| B. | One way to identify the most strongly supported clusters is simply to add the most weakly supported edges in the graph |
| C. | One way to identify the most strongly supported clusters is simply to remove the most weakly supported edges in the graph |
| D. | An edge is weighted according to the statistical significance of the alignment score |
| Answer» D. An edge is weighted according to the statistical significance of the alignment score | |
| 14. |
Which of the given statements is incorrect about Cluster analysis? |
| A. | Clustering organizes the proteins into groups by some objective criterion |
| B. | One criterion for a matching protein pair is the statistical significance of their alignment score |
| C. | The P or E value from BLAST searches cannot be the criterion for a matching protein pair |
| D. | A criterion for clustering proteins is the distance between each pair of sequences in a multiple sequence alignment |
| Answer» D. A criterion for clustering proteins is the distance between each pair of sequences in a multiple sequence alignment | |
| 15. |
Which of the given statements is incorrect about All-against-all Self-comparison? |
| A. | A comparison of each protein in the proteome with all other proteins distinguishes unique proteins from proteins that have arisen from gene duplication, and also reveals the number of protein families but the domain content of these proteins cannot be known |
| B. | In all-against-all proteome comparison, each protein is used as a query in a similarity search against the remaining proteome |
| C. | In all-against-all proteome comparison, the similar sequences are ranked by the quality and length of the alignments found |
| D. | In all-against-all proteome comparison, The search is conducted with each alignment score receiving a statistical evaluation (P or E value) |
| Answer» B. In all-against-all proteome comparison, each protein is used as a query in a similarity search against the remaining proteome | |
| 16. |
Which of the given statements is incorrect? |
| A. | Proteins may be clustered into families on the basis of either sequence or structural similarity |
| B. | Proteins often comprise separate domains |
| C. | The number of protein sequences that are available is insufficient to determine that domain shuffling occurs in evolution |
| D. | Proteins are modular |
| Answer» D. Proteins are modular | |
| 17. |
Which of the following information Sequence comparisons do not provide? |
| A. | Gene relationships |
| B. | Function history |
| C. | Evolutionary history |
| D. | Gene locations |
| Answer» E. | |
| 18. |
Comparative genomics includes a comparison of gene number, gene content, and gene location in both prokaryotic and eukaryotic groups of organisms. |
| A. | True |
| B. | False |
| Answer» B. False | |