Explore topic-wise MCQs in Bioinformatics.

This section includes 25 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.

1.

Match the entries in the Group Iwith the entries inGroup II.
Group IGroup II
P. Threading1. Gene duplication
Q. FASTA2. Fold prediction
R. Profile3. HMM
S. Paralogs4. k-tuple
A. P-2, Q-1, R-3, S-4
B. P-2, Q-4, R-3, S-1
C. P-3, Q-4, R-2, S-1
D. P-1, Q-4, R-3, S-2
Answer» C. P-3, Q-4, R-2, S-1
Discussion
2.

Consider the following multiple sequence alignment of four DNA sequences.
A C T A
A C T G
A G T C
A G C T
Shannon's entropy of the above alignment is __

A. 3.80 - 3.82 bits
B. 8.56 - 9.63 bits
C. 2.02 - 2.98 bits
D. 7.80 - 8.82 bits
Answer» B. 8.56 - 9.63 bits
Discussion
3.

Identify the file format given below:
>Pl; JMFD
Protein X Homo sapiens
MKALTARQQEVFDLIRDHISRTLRQQGDWL

A. GDE
B. FASTA
C. NBRF
D. GCG
Answer» D. GCG
Discussion
4.

Determine the correctness or otherwise of the following Assertion (A) and Reason (R).
Assertion: UPGMA method produces ultrametric tree.
Reason:Sequence alignment is converted into evolutionary distances in UPGMA method.

A. Both (A) and (R) are true and (R) is the correct reason for (A)
B. Both (A) and (R) are true and (R) is not the correct reason for (A)
C. (A) is true but (R) is false
D. (A) is false but (R) is true
Answer» C. (A) is true but (R) is false
Discussion
5.

For prediction of three dimensional structure of protein
(P) homology modeling tries many possible alignments
(Q) threading first identifies homologues
(R) threading evaluates many rough models
(S) homology modeling optimizes one model

A. Q, S
B. P, Q
C. R, S
D. Q, R
Answer» D. Q, R
Discussion
6.

Match the methods available on world wide web in group 1 for performing the jobs listed in group 2
Group 1Group 2
P. Boxshade1. Searching family data base
Q. BCM launcher2. Finding alignments
R. Prosite3. Displaying alignments
S. PSI-BLAST4. Searching for multiple alignments
A. P-l, Q-3, R-2, S-4
B. P-2, Q-3, R-2, S-4
C. P-3, Q-4, R-l, S-4
D. P-3, Q-2, R-l, S-4
Answer» E.
Discussion
7.

Match the item in Group I with an appropriate description in Group 2 :
Group 1Group 2
P. UPGMA1. Protein sequence database
Q. CLUSTAL2. Phylogenetic analysis
R. SWISS-PROT3. 3-D structure visualization
S. RasMOl4. Multiple sequence alignment
A. P-4, Q-1, R-2, S-3
B. P-2, Q-4, R-1, S-3
C. P-2, Q-3, R-1, S-4
D. P-2, Q-1, R-4, S-3
Answer» C. P-2, Q-3, R-1, S-4
Discussion
8.

The algorithm for BLAST is based on

A. Dynamic Programming
B. Hidden Markov Model
C. k-tuple analysis
D. Neural Network
Answer» D. Neural Network
Discussion
9.

How many rooted and unrooted phylogenetic trees, respectively, are possible with four different sequences ?

A. 3 and 15
B. 15 and 3
C. 15 and 12
D. 12 and 3
Answer» C. 15 and 12
Discussion
10.

An example of a derived protein structure database is

A. Pfam
B. SCOP
C. GEO
D. Prosite
Answer» C. GEO
Discussion
11.

Consider the following multiple sequence alignment of four DNA sequences.

A. 3.80 - 3.82 bits
B. 8.56 - 9.63 bits
C. 2.02 - 2.98 bits
D. 7.80 - 8.82 bits
Answer» B. 8.56 - 9.63 bits
Discussion
12.

Identify the file format given below:

A. GDE
B. FASTA
C. NBRF
D. GCG
Answer» D. GCG
Discussion
13.

Match the entries in the Group Iwith the entries inGroup II.

A. P-2, Q-1, R-3, S-4
B. P-2, Q-4, R-3, S-1
C. P-3, Q-4, R-2, S-1
D. P-1, Q-4, R-3, S-2
Answer» C. P-3, Q-4, R-2, S-1
Discussion
14.

The amino acid substitution matrices in decreasing order of stringency for comparing protein sequences are

A. PAM250, PAM120, PAM100
B. PAM100, PAM120, PAM250
C. PAM250, PAM100, PAM120
D. PAM120, PAM250, PAM100
Answer» C. PAM250, PAM100, PAM120
Discussion
15.

In an affine gap penalty model, if the gap opening penalty is -20, gap extension penalty is -4 and gap length is 8, the gap score is ___.

A. - 30 to -5
B. - 40 to -40
C. - 52 to -52
D. - 65 to -40
Answer» D. - 65 to -40
Discussion
16.

The method used for prediction of three dimensional structure of a protein from known structure(s) of one or more related proteins is

A. Multiple sequence alignment
B. Homology modeling
C. Phylogeny
D. Docking
Answer» C. Phylogeny
Discussion
17.

The most widely used program for multiple sequence alignment is

A. BLAST
B. FASTA
C. CLUSTAL
D. Chime
Answer» D. Chime
Discussion
18.

The suitable substitution matrix to align closely related sequences is

A. PAM 250 or BLOSSUM 80
B. PAM 40 or BLOSSUM 80
C. PAM 120 or BLOSSUM 40
D. PAM 250 or BLOSSUM 40
Answer» C. PAM 120 or BLOSSUM 40
Discussion
19.

Synteny refers to

A. gene duplication from a common ancestor
B. a tree representation of related sequences
C. the extent of similarity between two sequences
D. local conservation of gene order
Answer» E.
Discussion
20.

Accession number is a unique identification assigned to a

A. single database entry for DNA/Protein
B. single database entry for DNA only
C. single database entry for Protein only
D. multiple database entry for DNA/Protein
Answer» B. single database entry for DNA only
Discussion
21.

Program used for essentially local similarity search is

A. BLAST
B. RasMol
C. ExPASY
D. SWISS-PROT
Answer» B. RasMol
Discussion
22.

Match the methods available on world wide web in group 1 for performing the jobs listed in group 2

A. P-l, Q-3, R-2, S-4
B. P-2, Q-3, R-2, S-4
C. P-3, Q-4, R-l, S-4
D. P-3, Q-2, R-l, S-4
Answer» E.
Discussion
23.

For prediction of three dimensional structure of protein

A. Q, S
B. P, Q
C. R, S
D. Q, R
Answer» D. Q, R
Discussion
24.

In bioinformatics, the term BLAST refers to

A. database retrieval tool
B. computational tool for sequence homology searching and alignment
C. computational tool to view genomic sequences
D. computational tool to view protein structures
Answer» C. computational tool to view genomic sequences
Discussion
25.

Match the item in Group I with an appropriate description in Group 2 :

A. P-4, Q-1, R-2, S-3
B. P-2, Q-4, R-1, S-3
C. P-2, Q-3, R-1, S-4
D. P-2, Q-1, R-4, S-3
Answer» C. P-2, Q-3, R-1, S-4
Discussion