Which of the following is untrue about Ab initio prediction?

The perceived advantage of this method is that predictions are not restricted by known folds and that novel protein folds can be identified

The limited knowledge of protein folding forms the basis of ab initio prediction

The ab initio prediction method attempts to produce all-atom protein models based on sequence information alone without the aid of known protein structures

The ab initio prediction method attempts to produce all-atom protein models based on sequence information alone with some aid of known protein structures

The perceived advantage of this method is that predictions are not restricted by known folds and that novel protein folds can be identified

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1.	Which of the following is untrue about Ab initio prediction?
A.	The limited knowledge of protein folding forms the basis of ab initio prediction
B.	The ab initio prediction method attempts to produce all-atom protein models based on sequence information alone without the aid of known protein structures
C.	The ab initio prediction method attempts to produce all-atom protein models based on sequence information alone with some aid of known protein structures
D.	The perceived advantage of this method is that predictions are not restricted by known folds and that novel protein folds can be identified
Answer» D. The perceived advantage of this method is that predictions are not restricted by known folds and that novel protein folds can be identified

Discussion

2.	Energy minimization has to be used with caution because excessive energy minimization often moves residues away from their correct positions.
A.	True
B.	False
Answer» B. False

Discussion

3.	In the step of Model Refinement Using Energy Function, the structural irregularities can be corrected by applying the energy minimization procedure on the entire model, which moves the atoms in such a way that the overall conformation has the lowest energy potential.
A.	True
B.	False
Answer» B. False

Discussion

4.	In Side Chain Refinement step, A side chain can be built by searching every possible conformation at every torsion angle of the side chain to select the one that has the lowest interaction energy with neighboring atoms.
A.	True
B.	False
Answer» B. False

Discussion

Explore topic-wise MCQs in Bioinformatics.

Which of the following is untrue about Ab initio prediction?

Energy minimization has to be used with caution because excessive energy minimization often moves residues away from their correct positions.

In the step of Model Refinement Using Energy Function, the structural irregularities can be corrected by applying the energy minimization procedure on the entire model, which moves the atoms in such a way that the overall conformation has the lowest energy potential.

In Side Chain Refinement step, A side chain can be built by searching every possible conformation at every torsion angle of the side chain to select the one that has the lowest interaction energy with neighboring atoms.