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This section includes 7 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.
1. |
Which of the following about the RNAFold is incorrect? |
A. | It extends the sequence alignment to the vicinity of the optimal diagonals to calculate thermodynamic stability of alternative structures |
B. | It incorporates a partition function |
C. | It doesn t necessarily use a partition function |
D. | It aims to select a number of statistically most probable structures in one of its steps |
Answer» D. It aims to select a number of statistically most probable structures in one of its steps | |
2. |
Like Mfold, RNAfold only examines the energy terms of the optimal alignment in a dot plot. |
A. | True |
B. | False |
Answer» C. | |
3. |
Which of the following is correct about MFOLD? |
A. | It uses the dynamic programming only |
B. | It uses the thermodynamic calculations only |
C. | It uses the both dynamic programming and thermodynamic calculations as well |
D. | It doesn t take into account the themoststablility of the secondary structures |
Answer» C. It uses the both dynamic programming and thermodynamic calculations as well | |
4. |
The problem of dynamic programming to select one single structure can be complemented by adding a probability distribution function, known as the _________ which calculates a mathematical distribution of probable base pairs in thermodynamic equilibrium. |
A. | partition function |
B. | division function |
C. | increment function |
D. | fold function |
Answer» B. division function | |
5. |
In dynamic programming, in ab initio methods, Often ________ base pairing and energy terms of the base pairing _____ incorporated into the scoring process. |
A. | G-C, are |
B. | G U, are not |
C. | G U, are also |
D. | G-C, are not |
Answer» D. G-C, are not | |
6. |
In dynamic programming, in ab initio methods, the use of a dot plot can be effective in finding a ____ secondary structure in a ________ molecule. |
A. | multiple, large |
B. | single, large |
C. | single, small |
D. | multiple, small |
Answer» D. multiple, small | |
7. |
In dot matrix in ab initio methods, the diagonals _____________ to the main diagonal represent regions that can self hybridize. |
A. | parallel |
B. | cutting in random fashion |
C. | perpendicular |
D. | adjacent parallel |
Answer» D. adjacent parallel | |