Explore topic-wise MCQs in Bioinformatics.

This section includes 17 Mcqs, each offering curated multiple-choice questions to sharpen your Bioinformatics knowledge and support exam preparation. Choose a topic below to get started.

1.

Which of the following about the RNAFold is incorrect?

A. It extends the sequence alignment to the vicinity of the optimal diagonals to calculate thermodynamic stability of alternative structures
B. It incorporates a partition function
C. It doesn’t necessarily use a partition function
D. It aims to select a number of statistically most probable structures in one of its steps
Answer» D. It aims to select a number of statistically most probable structures in one of its steps
Discussion
2.

Like Mfold, RNAfold only examines the energy terms of the optimal alignment in a dot plot.

A. True
B. False
Answer» C.
Discussion
3.

Which of the following is correct about MFOLD?

A. It uses the dynamic programming only
B. It uses the thermodynamic calculations only
C. It uses the both dynamic programming and thermodynamic calculations as well
D. It doesn’t take into account the themoststablility of the secondary structures
Answer» C. It uses the both dynamic programming and thermodynamic calculations as well
Discussion
4.

The problem of dynamic programming to select one single structure can be complemented by adding a probability distribution function, known as the _________ which calculates a mathematical distribution of probable base pairs in thermodynamic equilibrium.

A. partition function
B. division function
C. increment function
D. fold function
Answer» B. division function
Discussion
5.

In dynamic programming, in ab initio methods, Often ________ base pairing and energy terms of the base pairing _____ incorporated into the scoring process.

A. G-C, are
B. G–U, are not
C. G–U, are also
D. G-C, are not
Answer» D. G-C, are not
Discussion
6.

In dynamic programming, in ab initio methods, the use of a dot plot can be effective in finding a ____ secondary structure in a ________ molecule.

A. multiple, large
B. single, large
C. single, small
D. multiple, small
Answer» D. multiple, small
Discussion
7.

In dot matrix in ab initio methods, the diagonals _____________ to the main diagonal represent regions that can self hybridize.

A. parallel
B. cutting in random fashion
C. perpendicular
D. adjacent parallel
Answer» D. adjacent parallel
Discussion
8.

LIKE_MFOLD,_RNAFOLD_ONLY_EXAMINES_THE_ENERGY_TERMS_OF_THE_OPTIMAL_ALIGNMENT_IN_A_DOT_PLOT.?$

A. True
B. False
Answer» C.
Discussion
9.

Which_of_the_following_about_the_RNAFold_is_incorrect?$

A. It extends the sequence alignment to the vicinity of the optimal diagonals to calculate thermodynamic stability of alternative structures
B. It incorporates a partition function
C. It doesn’t necessarily use a partition function
D. It aims to select a number of statistically most probable structures in one of its steps
Answer» D. It aims to select a number of statistically most probable structures in one of its steps
Discussion
10.

Which of following is correct about MFOLD?

A. It uses the dynamic programming only
B. It uses the thermodynamic calculations only
C. It uses the both dynamic programming and thermodynamic calculations as well
D. It doesn’t take into account the themoststablility of the secondary structures
Answer» C. It uses the both dynamic programming and thermodynamic calculations as well
Discussion
11.

The problem of dynamic programming to select one single structure can be complemented by adding a probability distribution function, known as the _________ which calculates a mathematical distribution of probable base pairs in a thermodynamic equilibrium.

A. partition function
B. division function
C. increment function
D. fold function
Answer» B. division function
Discussion
12.

The dynamic programming method produces ____ structure with _____ score.

A. one, single best
B. multiple, single best
C. multiple, multiple
D. single, multiple
Answer» B. multiple, single best
Discussion
13.

In dynamic programming, in ab initio methods, Often, ____ base pairing and energy terms of the base pairing _____ incorporated into the scoring process.

A. G-C, are
B. G–U, are not
C. G–U, are also
D. G-C, are not
Answer» D. G-C, are not
Discussion
14.

In ab initio methods, a quantitative approach such as dynamic programming can be used to assemble a final structure with optimal base-paired regions.

A. True
B. False
Answer» B. False
Discussion
15.

In dynamic programming, in ab initio methods, the use of a dot plot can be effective in finding a ____ secondary structure in a ____ molecule.

A. multiple, large
B. single, large
C. single, small
D. multiple, small
Answer» D. multiple, small
Discussion
16.

In dot matrix in ab initio methods, one way to reduce the noise in the matrix is to select an appropriate window size of a maximum number of contiguous base matches.

A. True
B. False
Answer» C.
Discussion
17.

In dot matrix in ab initio methods, the diagonals _____ to the main diagonal represent regions that can self hybridize.

A. parallel
B. cutting in random fashion
C. perpendicular
D. adjacent parallel
Answer» D. adjacent parallel
Discussion