With reference to optimal management of patients with sepsis in the intensive care unit, all of the following interventions are evidence-based except -

• A. Low tidal volume during assisted ventilation prevents acute lung injury
• B. For outcome of goal-oriented management of sepsis patients, monitoring of central venous pressure, hourly urine output and blood pressure is adequate
• C. Intensive blood glucose monitoring and prevention of hyperglycemia improves survival in critically ill patients
• D. The use of drotrecogin-Alpha is restricted to severally ill patients with APACHE score greater than equal to 25